Serum Immunoglobulin E and Risk of Pancreatic Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
Epidemiologic studies have consistently found that self-reported allergies are associated with reduced risk of pancreatic cancer. Our aim was to prospectively assess the relationship between serum immunoglobulin E (IgE), a marker of allergy, and risk. This nested case-control study within the Prosta...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2014-07, Vol.23 (7), p.1414-1420 |
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| creator | OLSON, Sara H HSU, Meier STOLZENBERG-SOLOMON, Rachael Z WIEMELS, Joseph L BRACCI, Paige M MI ZHOU PATOKA, Joseph REISACHER, William R WANG, Julie KURTZ, Robert C SILVERMAN, Debra T |
| description | Epidemiologic studies have consistently found that self-reported allergies are associated with reduced risk of pancreatic cancer. Our aim was to prospectively assess the relationship between serum immunoglobulin E (IgE), a marker of allergy, and risk. This nested case-control study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) included subjects enrolled in 1994 to 2001 and followed through 2010. There were 283 cases of pancreatic cancer and 544 controls matched on age, gender, race, and calendar date of blood draw. Using the ImmunoCAP system, we measured total IgE (normal, borderline, elevated), IgE to respiratory allergens, and IgE to food allergens (negative or positive) in serum collected at baseline. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression. We assessed interactions with age, gender, smoking, body mass index, and time between randomization and case diagnosis. Overall, there was no association between the IgE measures and risk. We found a statistically significant interaction by baseline age: in those aged ≥65 years, elevated risks were observed for borderline total IgE (OR, 1.43; 95% CI, 0.88-2.32) and elevated total IgE (OR, 1.98; 95% CI, 1.16-3.37) and positive IgE to food allergens (OR, 2.83; 95% CI, 1.29-6.20); among participants |
| doi_str_mv | 10.1158/1055-9965.EPI-13-1359 |
| format | Article |
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Our aim was to prospectively assess the relationship between serum immunoglobulin E (IgE), a marker of allergy, and risk. This nested case-control study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) included subjects enrolled in 1994 to 2001 and followed through 2010. There were 283 cases of pancreatic cancer and 544 controls matched on age, gender, race, and calendar date of blood draw. Using the ImmunoCAP system, we measured total IgE (normal, borderline, elevated), IgE to respiratory allergens, and IgE to food allergens (negative or positive) in serum collected at baseline. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression. We assessed interactions with age, gender, smoking, body mass index, and time between randomization and case diagnosis. Overall, there was no association between the IgE measures and risk. We found a statistically significant interaction by baseline age: in those aged ≥65 years, elevated risks were observed for borderline total IgE (OR, 1.43; 95% CI, 0.88-2.32) and elevated total IgE (OR, 1.98; 95% CI, 1.16-3.37) and positive IgE to food allergens (OR, 2.83; 95% CI, 1.29-6.20); among participants <65 years, ORs were <1. Other interactions were not statistically significant. The reduced risk of pancreatic cancer associated with self-reported allergies is not reflected in serum IgE.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-13-1359</identifier><identifier>PMID: 24718282</identifier><identifier>CODEN: CEBPE4</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adenocarcinoma - blood ; Adenocarcinoma - epidemiology ; Aged ; Biological and medical sciences ; Case-Control Studies ; Early Detection of Cancer ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Hypersensitivity - epidemiology ; Immunoglobulin E - blood ; Incidence ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Mass Screening ; Medical sciences ; Middle Aged ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Nephrology. Urinary tract diseases ; Odds Ratio ; Pancreatic Neoplasms - blood ; Pancreatic Neoplasms - epidemiology ; Risk Factors ; Tumors ; Tumors of the urinary system ; Urinary tract. Prostate gland</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2014-07, Vol.23 (7), p.1414-1420</ispartof><rights>2015 INIST-CNRS</rights><rights>2014 American Association for Cancer Research.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-596dfa740fc3025a7ce4f7fbbd800420fc6f11871395349770ec571a2985ecd13</citedby><cites>FETCH-LOGICAL-c386t-596dfa740fc3025a7ce4f7fbbd800420fc6f11871395349770ec571a2985ecd13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3354,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28663728$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24718282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OLSON, Sara H</creatorcontrib><creatorcontrib>HSU, Meier</creatorcontrib><creatorcontrib>STOLZENBERG-SOLOMON, Rachael Z</creatorcontrib><creatorcontrib>WIEMELS, Joseph L</creatorcontrib><creatorcontrib>BRACCI, Paige M</creatorcontrib><creatorcontrib>MI ZHOU</creatorcontrib><creatorcontrib>PATOKA, Joseph</creatorcontrib><creatorcontrib>REISACHER, William R</creatorcontrib><creatorcontrib>WANG, Julie</creatorcontrib><creatorcontrib>KURTZ, Robert C</creatorcontrib><creatorcontrib>SILVERMAN, Debra T</creatorcontrib><title>Serum Immunoglobulin E and Risk of Pancreatic Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Epidemiologic studies have consistently found that self-reported allergies are associated with reduced risk of pancreatic cancer. Our aim was to prospectively assess the relationship between serum immunoglobulin E (IgE), a marker of allergy, and risk. This nested case-control study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) included subjects enrolled in 1994 to 2001 and followed through 2010. There were 283 cases of pancreatic cancer and 544 controls matched on age, gender, race, and calendar date of blood draw. Using the ImmunoCAP system, we measured total IgE (normal, borderline, elevated), IgE to respiratory allergens, and IgE to food allergens (negative or positive) in serum collected at baseline. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression. We assessed interactions with age, gender, smoking, body mass index, and time between randomization and case diagnosis. Overall, there was no association between the IgE measures and risk. We found a statistically significant interaction by baseline age: in those aged ≥65 years, elevated risks were observed for borderline total IgE (OR, 1.43; 95% CI, 0.88-2.32) and elevated total IgE (OR, 1.98; 95% CI, 1.16-3.37) and positive IgE to food allergens (OR, 2.83; 95% CI, 1.29-6.20); among participants <65 years, ORs were <1. Other interactions were not statistically significant. The reduced risk of pancreatic cancer associated with self-reported allergies is not reflected in serum IgE.</description><subject>Adenocarcinoma - blood</subject><subject>Adenocarcinoma - epidemiology</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Early Detection of Cancer</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Hypersensitivity - epidemiology</subject><subject>Immunoglobulin E - blood</subject><subject>Incidence</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Mass Screening</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Odds Ratio</subject><subject>Pancreatic Neoplasms - blood</subject><subject>Pancreatic Neoplasms - epidemiology</subject><subject>Risk Factors</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. Prostate gland</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkF1r2zAUhsVYabO0P2FDN4NdxK1k-VjS5QhZFwg09ONaKLKUeZPlTLIL66-vsiQtCHQ4PO8r9CD0mZJrSkHcUAJQSFnD9WK9LCjLB-QHNKHARME5wMc8n5gL9Cml34QQLgHO0UVZcSpKUU7Qy4ONY4eXXTeGfuv7zejbgBdYhwbft-kP7h1e62Ci1UNr8DyPNuKMDL8sXsc-DXqwM7waw3aG573vozWD9rP_BXfPOrY6nFIPucWGNmzxY177S3TmtE_26nhP0dOPxeP8Z7G6u13Ov68Kw0Q9FCDrxmleEWcYKUFzYyvH3WbTCEKqMq9rR6nglElgleScWAOc6lIKsKahbIq-HXp3sf872jSork3Geq-D7cekKFSs5LKiPKNwQE3-WYrWqV1sOx3_KUrUXrvaK1V7pSprV5Spvfac-3J8Ytx0tnlLnTxn4OsR0Mlo72I20qZ3TtQ146Vgr-k6ioI</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>OLSON, Sara H</creator><creator>HSU, Meier</creator><creator>STOLZENBERG-SOLOMON, Rachael Z</creator><creator>WIEMELS, Joseph L</creator><creator>BRACCI, Paige M</creator><creator>MI ZHOU</creator><creator>PATOKA, Joseph</creator><creator>REISACHER, William R</creator><creator>WANG, Julie</creator><creator>KURTZ, Robert C</creator><creator>SILVERMAN, Debra T</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140701</creationdate><title>Serum Immunoglobulin E and Risk of Pancreatic Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial</title><author>OLSON, Sara H ; HSU, Meier ; STOLZENBERG-SOLOMON, Rachael Z ; WIEMELS, Joseph L ; BRACCI, Paige M ; MI ZHOU ; PATOKA, Joseph ; REISACHER, William R ; WANG, Julie ; KURTZ, Robert C ; SILVERMAN, Debra T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-596dfa740fc3025a7ce4f7fbbd800420fc6f11871395349770ec571a2985ecd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adenocarcinoma - blood</topic><topic>Adenocarcinoma - epidemiology</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Early Detection of Cancer</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Hypersensitivity - epidemiology</topic><topic>Immunoglobulin E - blood</topic><topic>Incidence</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Mass Screening</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Odds Ratio</topic><topic>Pancreatic Neoplasms - blood</topic><topic>Pancreatic Neoplasms - epidemiology</topic><topic>Risk Factors</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OLSON, Sara H</creatorcontrib><creatorcontrib>HSU, Meier</creatorcontrib><creatorcontrib>STOLZENBERG-SOLOMON, Rachael Z</creatorcontrib><creatorcontrib>WIEMELS, Joseph L</creatorcontrib><creatorcontrib>BRACCI, Paige M</creatorcontrib><creatorcontrib>MI ZHOU</creatorcontrib><creatorcontrib>PATOKA, Joseph</creatorcontrib><creatorcontrib>REISACHER, William R</creatorcontrib><creatorcontrib>WANG, Julie</creatorcontrib><creatorcontrib>KURTZ, Robert C</creatorcontrib><creatorcontrib>SILVERMAN, Debra T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OLSON, Sara H</au><au>HSU, Meier</au><au>STOLZENBERG-SOLOMON, Rachael Z</au><au>WIEMELS, Joseph L</au><au>BRACCI, Paige M</au><au>MI ZHOU</au><au>PATOKA, Joseph</au><au>REISACHER, William R</au><au>WANG, Julie</au><au>KURTZ, Robert C</au><au>SILVERMAN, Debra T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Immunoglobulin E and Risk of Pancreatic Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>23</volume><issue>7</issue><spage>1414</spage><epage>1420</epage><pages>1414-1420</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><coden>CEBPE4</coden><abstract>Epidemiologic studies have consistently found that self-reported allergies are associated with reduced risk of pancreatic cancer. Our aim was to prospectively assess the relationship between serum immunoglobulin E (IgE), a marker of allergy, and risk. This nested case-control study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) included subjects enrolled in 1994 to 2001 and followed through 2010. There were 283 cases of pancreatic cancer and 544 controls matched on age, gender, race, and calendar date of blood draw. Using the ImmunoCAP system, we measured total IgE (normal, borderline, elevated), IgE to respiratory allergens, and IgE to food allergens (negative or positive) in serum collected at baseline. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression. We assessed interactions with age, gender, smoking, body mass index, and time between randomization and case diagnosis. Overall, there was no association between the IgE measures and risk. We found a statistically significant interaction by baseline age: in those aged ≥65 years, elevated risks were observed for borderline total IgE (OR, 1.43; 95% CI, 0.88-2.32) and elevated total IgE (OR, 1.98; 95% CI, 1.16-3.37) and positive IgE to food allergens (OR, 2.83; 95% CI, 1.29-6.20); among participants <65 years, ORs were <1. Other interactions were not statistically significant. The reduced risk of pancreatic cancer associated with self-reported allergies is not reflected in serum IgE.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>24718282</pmid><doi>10.1158/1055-9965.EPI-13-1359</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | Adenocarcinoma - blood Adenocarcinoma - epidemiology Aged Biological and medical sciences Case-Control Studies Early Detection of Cancer Female Gastroenterology. Liver. Pancreas. Abdomen Humans Hypersensitivity - epidemiology Immunoglobulin E - blood Incidence Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Mass Screening Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Nephrology. Urinary tract diseases Odds Ratio Pancreatic Neoplasms - blood Pancreatic Neoplasms - epidemiology Risk Factors Tumors Tumors of the urinary system Urinary tract. Prostate gland |
| title | Serum Immunoglobulin E and Risk of Pancreatic Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial |
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