Polychlorinated biphenyls (PCBs) inducible monooxygenases in rabbits and mice: Species and organ specificities

The effects of the PCBs mixture, Aroclor 1254, as modifiers of monooxygenases were studied in rabbits and mice. From data presented, it is not possible to generalize the biological effects of PCBs observed with rats, namely, that they are potent, nonspecific inducers of monooxygenase activities. Thi...

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Veröffentlicht in:	Life Sci.; (United States) 1982-03, Vol.30 (9), p.747-751
Hauptverfasser:	Alvares, A.P., Ueng, T.-H., Eiseman, J.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	ANIMALS Aroclors - pharmacology AROMATICS Aryl Hydrocarbon Hydroxylases - metabolism Benzopyrene Hydroxylase - metabolism BIOLOGICAL EFFECTS BODY CHEMICAL ACTIVATION CHLORINATED AROMATIC HYDROCARBONS Chlorodiphenyl (54% Chlorine) Cytochrome P-450 Enzyme System - biosynthesis Enzyme Induction ENZYMES Ethylmorphine-N-Demethylase - biosynthesis HALOGENATED AROMATIC HYDROCARBONS Kidney - enzymology KIDNEYS Liver - enzymology Lung - enzymology LUNGS Male MAMMALS MICE Mice, Inbred C57BL Mice, Inbred DBA ORGANIC CHLORINE COMPOUNDS ORGANIC COMPOUNDS ORGANIC HALOGEN COMPOUNDS ORGANS OXIDOREDUCTASES Oxidoreductases, N-Demethylating - biosynthesis OXYGENASES Polychlorinated Biphenyls - pharmacology RABBITS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RESPIRATORY SYSTEM RODENTS Species Specificity VERTEBRATES 560305 > Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
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