Cholestasis in the rat by means of intravenous administration of cyclosporine vehicle, Cremophor EL

The effect of cyclosporine vehicle, Cremophor EL, on bile flow and biliary bile acids and bilirubin output was studied in anesthetized male Wistar rats. Intravenous administration of Cremophor EL or castor oil as a single bolus reduced bile flow and the biliary output of bile acids and bilirubin. Th...

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Veröffentlicht in:	Transplantation 1989-10, Vol.48 (4), p.554-558
Hauptverfasser:	ROMAN, I. D, MONTE, M. J, ESTELLER, A, JIMENET, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Acids and Salts - metabolism Bilirubin - metabolism Biological and medical sciences Cholestasis - chemically induced Cyclosporins - administration & dosage Drug toxicity and drugs side effects treatment Glycerol - analogs & derivatives Glycerol - toxicity Medical sciences Pharmaceutical Vehicles - adverse effects Pharmacology. Drug treatments Rats Secretory Rate - drug effects Toxicity: digestive system
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