Design of gliadin peptide analogues with low affinity for the celiac disease associated HLA-DQ2 protein

The HLA-DQ2.5 receptors bind gluten-derived peptides and present them to the T cells in the intestinal mucosa thus inducing the development of immune responses typical of the celiac disease. On the basis of the X-ray structure of the domain of HLA-DQ2.5 bound to the DQ2.5-glia-α1a epitope, fifteen p...

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Veröffentlicht in:	Molecular bioSystems 2014-01, Vol.10 (8), p.2064-2073
Hauptverfasser:	Fraccalvieri, Domenico, Motta, Stefano, Galliani, Guido, Cavaletti, Linda, Bonati, Laura
Format:	Artikel
Sprache:	eng
Schlagworte:	Celiac Disease - immunology Drug Design Epitopes, T-Lymphocyte - chemistry Epitopes, T-Lymphocyte - immunology Epitopes, T-Lymphocyte - metabolism Gliadin - chemistry Gliadin - immunology HLA-DQ Antigens - chemistry HLA-DQ Antigens - metabolism Humans Hydroxylation Models, Molecular Molecular Docking Simulation Peptides - chemistry Peptides - metabolism
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