Complement C5a Receptor Facilitates Cancer Metastasis by Altering T-Cell Responses in the Metastatic Niche

The impact of complement on cancer metastasis has not been well studied. In this report, we demonstrate in a preclinical mouse model of breast cancer that the complement anaphylatoxin C5a receptor (C5aR) facilitates metastasis by suppressing effector CD8(+) and CD4(+) T-cell responses in the lungs....

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2014-07, Vol.74 (13), p.3454-3465
Hauptverfasser:	SURYA KUMARI VADREVU, CHINTALA, Navin K, KARBOWNICZEK, Magdalena, MARKIEWSKI, Maciej M, SHARMA, Sharad K, SHARMA, Priya, CLEVELAND, Clayton, RIEDIGER, Linley, MANNE, Sasikanth, FAIRLIE, David P, GORCZYCA, Wojciech, ALMANZA, Othon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Cell Line, Tumor Complement C5a - immunology Female Immunosuppression Interleukin-10 - biosynthesis Liver Neoplasms - immunology Liver Neoplasms - secondary Lung - immunology Lung Neoplasms - immunology Lung Neoplasms - secondary Mammary Neoplasms, Experimental - immunology Medical sciences Mice Mice, Inbred BALB C Mice, Knockout Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Metastasis Pharmacology. Drug treatments Receptor, Anaphylatoxin C5a - antagonists & inhibitors Receptor, Anaphylatoxin C5a - genetics Receptor, Anaphylatoxin C5a - immunology Signal Transduction - genetics Signal Transduction - immunology T-Lymphocytes, Regulatory - immunology Transforming Growth Factor beta - biosynthesis Tumors
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