Novel mechanisms of Na+ retention in obesity: phosphorylation of NKCC2 and regulation of SPAK/OSR1 by AMPK

Enhanced tubular reabsorption of salt is important in the pathogenesis of obesity-related hypertension, but the mechanisms remain poorly defined. To identify changes in the regulation of salt transporters in the kidney, C57BL/6 mice were fed a 40% fat diet [high-fat diet (HFD)] or a 12% fat diet (co...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2014-07, Vol.307 (1), p.F96-F106
Hauptverfasser:	Davies, Matthew, Fraser, Scott A, Galic, Sandra, Choy, Suet-Wan, Katerelos, Marina, Gleich, Kurt, Kemp, Bruce E, Mount, Peter F, Power, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - metabolism Animals Epithelial Sodium Channels - metabolism Experiments Kidney - metabolism Kinases Mice Mice, Inbred C57BL Obesity Obesity - metabolism Pathogenesis Phosphorylation Protein-Serine-Threonine Kinases - metabolism Rodents Salt Sodium Chloride, Dietary - metabolism Solute Carrier Family 12, Member 1 - metabolism
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