Successful treatment of eosinophilic granulomatosis with polyangiitis (EGPA; formerly Churg–Strauss syndrome) with rituximab in a case refractory to glucocorticoids, cyclophosphamide, and IVIG
Abstract A 44-year old woman with eosinophilic granulomatosis with polyangiitis (EGPA) developed sequential paralysis of different cranial nerves despite treatments including methylpredonisolone pulse therapy, intravenous immunoglobulins (IVIG), and cyclophosphamide. Infusions of rituximab ameliorat...
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| Veröffentlicht in: | Modern rheumatology 2014-07, Vol.24 (4), p.685-687 |
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| container_title | Modern rheumatology |
| container_volume | 24 |
| creator | Umezawa, Natsuka Kohsaka, Hitoshi Nanki, Toshihiro Watanabe, Kaori Tanaka, Michi Shane, Peter Y. Miyasaka, Nobuyuki |
| description | Abstract
A 44-year old woman with eosinophilic granulomatosis with polyangiitis (EGPA) developed sequential paralysis of different cranial nerves despite treatments including methylpredonisolone pulse therapy, intravenous immunoglobulins (IVIG), and cyclophosphamide. Infusions of rituximab ameliorated her neurological symptoms and serological inflammatory findings. Rituximab, a specific B cell-targeting therapy, might offer an alternative for refractory EGPA with possible advantages of cost and ease of use compared to IVIG, which also targets (at least in part) B lymphocytes and immunoglobulin production. |
| doi_str_mv | 10.3109/14397595.2013.874734 |
| format | Article |
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A 44-year old woman with eosinophilic granulomatosis with polyangiitis (EGPA) developed sequential paralysis of different cranial nerves despite treatments including methylpredonisolone pulse therapy, intravenous immunoglobulins (IVIG), and cyclophosphamide. Infusions of rituximab ameliorated her neurological symptoms and serological inflammatory findings. Rituximab, a specific B cell-targeting therapy, might offer an alternative for refractory EGPA with possible advantages of cost and ease of use compared to IVIG, which also targets (at least in part) B lymphocytes and immunoglobulin production.</description><identifier>ISSN: 1439-7595</identifier><identifier>EISSN: 1439-7609</identifier><identifier>DOI: 10.3109/14397595.2013.874734</identifier><identifier>PMID: 24517553</identifier><language>eng</language><publisher>United States: Informa Healthcare</publisher><subject>Adult ; Antibodies, Monoclonal, Murine-Derived - therapeutic use ; Autoimmune diseases ; Churg-Strauss Syndrome - drug therapy ; Cyclophosphamide - therapeutic use ; Drug therapy ; Female ; Glucocorticoids - therapeutic use ; Humans ; Immunoglobulins, Intravenous - therapeutic use ; Immunologic Factors - therapeutic use ; Prescription drugs ; Retreatment ; Rituximab ; Treatment Outcome</subject><ispartof>Modern rheumatology, 2014-07, Vol.24 (4), p.685-687</ispartof><rights>2014 Japan College of Rheumatology 2014</rights><rights>Copyright Informa Healthcare Jul 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-4365fb47723ea802b6f1218de70eb9372f5d44c7edb1d7136b05ce9e8de2548e3</citedby><cites>FETCH-LOGICAL-c414t-4365fb47723ea802b6f1218de70eb9372f5d44c7edb1d7136b05ce9e8de2548e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24517553$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Umezawa, Natsuka</creatorcontrib><creatorcontrib>Kohsaka, Hitoshi</creatorcontrib><creatorcontrib>Nanki, Toshihiro</creatorcontrib><creatorcontrib>Watanabe, Kaori</creatorcontrib><creatorcontrib>Tanaka, Michi</creatorcontrib><creatorcontrib>Shane, Peter Y.</creatorcontrib><creatorcontrib>Miyasaka, Nobuyuki</creatorcontrib><title>Successful treatment of eosinophilic granulomatosis with polyangiitis (EGPA; formerly Churg–Strauss syndrome) with rituximab in a case refractory to glucocorticoids, cyclophosphamide, and IVIG</title><title>Modern rheumatology</title><addtitle>Mod Rheumatol</addtitle><description>Abstract
A 44-year old woman with eosinophilic granulomatosis with polyangiitis (EGPA) developed sequential paralysis of different cranial nerves despite treatments including methylpredonisolone pulse therapy, intravenous immunoglobulins (IVIG), and cyclophosphamide. Infusions of rituximab ameliorated her neurological symptoms and serological inflammatory findings. Rituximab, a specific B cell-targeting therapy, might offer an alternative for refractory EGPA with possible advantages of cost and ease of use compared to IVIG, which also targets (at least in part) B lymphocytes and immunoglobulin production.</description><subject>Adult</subject><subject>Antibodies, Monoclonal, Murine-Derived - therapeutic use</subject><subject>Autoimmune diseases</subject><subject>Churg-Strauss Syndrome - drug therapy</subject><subject>Cyclophosphamide - therapeutic use</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Humans</subject><subject>Immunoglobulins, Intravenous - therapeutic use</subject><subject>Immunologic Factors - therapeutic use</subject><subject>Prescription drugs</subject><subject>Retreatment</subject><subject>Rituximab</subject><subject>Treatment Outcome</subject><issn>1439-7595</issn><issn>1439-7609</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd-K1DAUh4so7rr6BiIBb1bYGZMmaVoEYRnWcWBBYdXbkqan0yxpM5s_aO98B9_IR_FJTOmOiBdeJRy-38k5-bLsOcFrSnD1mjBaCV7xdY4JXZeCCcoeZKdzeSUKXD083hNzkj3x_hZjyquyepyd5IwTwTk9zX7eRKXA-y4aFBzIMMAYkO0QWK9He-i10QrtnRyjsYMMqerRVx16dLBmkuNe65Aq51fbj5dvUGfdAM5MaNNHt__1_cdNcDJ6j_w0ts4O8GrJOh3iNz3IBukRSaSkB-Sgc1IF6yYULNqbqKyyLmhldesvkJqUSeNYf-jloFu4QHJs0e7Lbvs0e9RJ4-HZ_XmWfX539WnzfnX9YbvbXF6vFCMsrBgteNcwIXIKssR5U3QkJ2ULAkNTUZF3vGVMCWgb0gpCiwZzBRUkIuesBHqWnS99D87eRfChHrRXYIwcwUZfE87yvKpyUST05T_orY1uTNPNVLJSUMwTxRZKOet92r8-uPQpbqoJrmfH9dFxPTuuF8cp9uK-eWwGaP-EjlIT8HYB9DgLkT1IE3olHfw1xv9e-A0BLLrP</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Umezawa, Natsuka</creator><creator>Kohsaka, Hitoshi</creator><creator>Nanki, Toshihiro</creator><creator>Watanabe, Kaori</creator><creator>Tanaka, Michi</creator><creator>Shane, Peter Y.</creator><creator>Miyasaka, Nobuyuki</creator><general>Informa Healthcare</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20140701</creationdate><title>Successful treatment of eosinophilic granulomatosis with polyangiitis (EGPA; formerly Churg–Strauss syndrome) with rituximab in a case refractory to glucocorticoids, cyclophosphamide, and IVIG</title><author>Umezawa, Natsuka ; Kohsaka, Hitoshi ; Nanki, Toshihiro ; Watanabe, Kaori ; Tanaka, Michi ; Shane, Peter Y. ; Miyasaka, Nobuyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-4365fb47723ea802b6f1218de70eb9372f5d44c7edb1d7136b05ce9e8de2548e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Antibodies, Monoclonal, Murine-Derived - therapeutic use</topic><topic>Autoimmune diseases</topic><topic>Churg-Strauss Syndrome - drug therapy</topic><topic>Cyclophosphamide - therapeutic use</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Glucocorticoids - therapeutic use</topic><topic>Humans</topic><topic>Immunoglobulins, Intravenous - therapeutic use</topic><topic>Immunologic Factors - therapeutic use</topic><topic>Prescription drugs</topic><topic>Retreatment</topic><topic>Rituximab</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Umezawa, Natsuka</creatorcontrib><creatorcontrib>Kohsaka, Hitoshi</creatorcontrib><creatorcontrib>Nanki, Toshihiro</creatorcontrib><creatorcontrib>Watanabe, Kaori</creatorcontrib><creatorcontrib>Tanaka, Michi</creatorcontrib><creatorcontrib>Shane, Peter Y.</creatorcontrib><creatorcontrib>Miyasaka, Nobuyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Modern rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Umezawa, Natsuka</au><au>Kohsaka, Hitoshi</au><au>Nanki, Toshihiro</au><au>Watanabe, Kaori</au><au>Tanaka, Michi</au><au>Shane, Peter Y.</au><au>Miyasaka, Nobuyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful treatment of eosinophilic granulomatosis with polyangiitis (EGPA; 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A 44-year old woman with eosinophilic granulomatosis with polyangiitis (EGPA) developed sequential paralysis of different cranial nerves despite treatments including methylpredonisolone pulse therapy, intravenous immunoglobulins (IVIG), and cyclophosphamide. Infusions of rituximab ameliorated her neurological symptoms and serological inflammatory findings. Rituximab, a specific B cell-targeting therapy, might offer an alternative for refractory EGPA with possible advantages of cost and ease of use compared to IVIG, which also targets (at least in part) B lymphocytes and immunoglobulin production.</abstract><cop>United States</cop><pub>Informa Healthcare</pub><pmid>24517553</pmid><doi>10.3109/14397595.2013.874734</doi><tpages>3</tpages></addata></record> |
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| ispartof | Modern rheumatology, 2014-07, Vol.24 (4), p.685-687 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult Antibodies, Monoclonal, Murine-Derived - therapeutic use Autoimmune diseases Churg-Strauss Syndrome - drug therapy Cyclophosphamide - therapeutic use Drug therapy Female Glucocorticoids - therapeutic use Humans Immunoglobulins, Intravenous - therapeutic use Immunologic Factors - therapeutic use Prescription drugs Retreatment Rituximab Treatment Outcome |
| title | Successful treatment of eosinophilic granulomatosis with polyangiitis (EGPA; formerly Churg–Strauss syndrome) with rituximab in a case refractory to glucocorticoids, cyclophosphamide, and IVIG |
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