A case of micafungin-hyposensitive Candida glabrata due to FKS2 gene mutation
Candida glabrata was continuously isolated in cultured urine samples from a subject with thrombotic thrombocytopenic purpura. Yeast-like fungal phagocytosis found in gram staining led to agents being tested for antifungal susceptibility, revealing hyposensitivity to micafungin (MCFG) of MIC < 2 m...
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| Veröffentlicht in: | Kansenshōgaku zasshi 2014-05, Vol.88 (3 Suppl 9-10), p.6-10 |
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| container_issue | 3 Suppl 9-10 |
| container_start_page | 6 |
| container_title | Kansenshōgaku zasshi |
| container_volume | 88 |
| creator | Inui, Sachiko Nakamura, Tatsuya Tanabe, Kouichi Ohno, Hideaki Koike, Chihiro Okuda, Kazuyuki Nakata, Chiyo Fujimoto, Hiroko Ohkura, Hiroe Miyazaki, Yoshitsugu Takahashi, Hakuo |
| description | Candida glabrata was continuously isolated in cultured urine samples from a subject with thrombotic thrombocytopenic purpura. Yeast-like fungal phagocytosis found in gram staining led to agents being tested for antifungal susceptibility, revealing hyposensitivity to micafungin (MCFG) of MIC < 2 mg/mL. MCFG administered for 10 days failed to cure C. glabrata infection. To clarify why hyposensitivity occurred, we analyzed the FKS gene sequence using the PCR, finding a deficit of 3 bases coding phenylalanine at FKS2 gene amino acid 659. MCFG hyposensitivity may thus occur in long-term candin-class anti-fungal agent treatment. Candin-class agents have potent anti-fungal activity with fewer adverse effects and are widely used clinically. Hyposensitivity due to resistant C. glabrata species showed thus be considered in fungal infection treatment. |
| format | Article |
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Yeast-like fungal phagocytosis found in gram staining led to agents being tested for antifungal susceptibility, revealing hyposensitivity to micafungin (MCFG) of MIC < 2 mg/mL. MCFG administered for 10 days failed to cure C. glabrata infection. To clarify why hyposensitivity occurred, we analyzed the FKS gene sequence using the PCR, finding a deficit of 3 bases coding phenylalanine at FKS2 gene amino acid 659. MCFG hyposensitivity may thus occur in long-term candin-class anti-fungal agent treatment. Candin-class agents have potent anti-fungal activity with fewer adverse effects and are widely used clinically. 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Yeast-like fungal phagocytosis found in gram staining led to agents being tested for antifungal susceptibility, revealing hyposensitivity to micafungin (MCFG) of MIC < 2 mg/mL. MCFG administered for 10 days failed to cure C. glabrata infection. To clarify why hyposensitivity occurred, we analyzed the FKS gene sequence using the PCR, finding a deficit of 3 bases coding phenylalanine at FKS2 gene amino acid 659. MCFG hyposensitivity may thus occur in long-term candin-class anti-fungal agent treatment. Candin-class agents have potent anti-fungal activity with fewer adverse effects and are widely used clinically. 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Yeast-like fungal phagocytosis found in gram staining led to agents being tested for antifungal susceptibility, revealing hyposensitivity to micafungin (MCFG) of MIC < 2 mg/mL. MCFG administered for 10 days failed to cure C. glabrata infection. To clarify why hyposensitivity occurred, we analyzed the FKS gene sequence using the PCR, finding a deficit of 3 bases coding phenylalanine at FKS2 gene amino acid 659. MCFG hyposensitivity may thus occur in long-term candin-class anti-fungal agent treatment. Candin-class agents have potent anti-fungal activity with fewer adverse effects and are widely used clinically. Hyposensitivity due to resistant C. glabrata species showed thus be considered in fungal infection treatment.</abstract><cop>Japan</cop><pmid>24979950</pmid><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0387-5911 |
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| issn | 0387-5911 |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aged Antifungal Agents - pharmacology Candida glabrata - drug effects Candida glabrata - genetics Drug Resistance, Fungal Echinocandins - pharmacology Female Fungal Proteins - genetics Genes, Fungal - genetics Glucosyltransferases - genetics Humans Lipopeptides - pharmacology Membrane Proteins - genetics Mutation |
| title | A case of micafungin-hyposensitive Candida glabrata due to FKS2 gene mutation |
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