Role of Polymorphic Loci in HLA-Region rs2647012 and rs805288 in the Development of Non-Hodgkin’s Malignant Lymphomas in Western Siberia
The data of genome-wide association analysis suggest that human 6p21.3 chromosomal region (localization of HLA genes) contains polymorphic loci infl uencing the risk of developing non-Hodgkin’s lymphomas. We analyzed association of rs2647012 and rs805288 loci with the risk for non-Hodgkin’s malignan...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2014-06, Vol.157 (2), p.180-183 |
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| creator | Weiner, A. S. Berezina, O. V. Ovchinnikov, V. S. Surovtseva, M. N. Voropaeva, E. N. Pospelova, T. I. Filipenko, M. L. |
| description | The data of genome-wide association analysis suggest that human 6p21.3 chromosomal region (localization of
HLA
genes) contains polymorphic loci infl uencing the risk of developing non-Hodgkin’s lymphomas. We analyzed association of rs2647012 and rs805288 loci with the risk for non-Hodgkin’s malignant lymphomas in the population of Western Siberia. Allele and genotype frequencies were determined in the group of 298 patients and in the control group including 551 individuals. Subgroups of diffuse large B-cell lymphoma (86 patients) and follicular lymphoma (25 patients) were analyzed separately. An association of rs2647012 А/А genotype with increased risk of the disease (OR = 2.78,
p
= 0.002) was detected in the subgroup of diffuse large B-cell lymphoma. |
| doi_str_mv | 10.1007/s10517-014-2520-2 |
| format | Article |
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HLA
genes) contains polymorphic loci infl uencing the risk of developing non-Hodgkin’s lymphomas. We analyzed association of rs2647012 and rs805288 loci with the risk for non-Hodgkin’s malignant lymphomas in the population of Western Siberia. Allele and genotype frequencies were determined in the group of 298 patients and in the control group including 551 individuals. Subgroups of diffuse large B-cell lymphoma (86 patients) and follicular lymphoma (25 patients) were analyzed separately. An association of rs2647012 А/А genotype with increased risk of the disease (OR = 2.78,
p
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HLA
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p
= 0.002) was detected in the subgroup of diffuse large B-cell lymphoma.</description><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>B cells</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Female</subject><subject>General Pathology and Pathophysiology</subject><subject>Genome-Wide Association Study - methods</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Genotype</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Lymphoma, Non-Hodgkin - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Non-Hodgkin's lymphomas</subject><subject>Pathology</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Siberia</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kt-K1DAUxoso7rj6AN5IQRBvuuak6SS9HNY_I9Q_rAtehkx62mZtk27SCnPntW_g6_kkpswqs6LkIiTn932cw_mS5DGQMyCEvwhACuAZAZbRgpKM3klWUPA8E5TC3WRFIpQxIcRJ8iCEq-VJ1nA_OaGsLETOySr5fuF6TF2TfnT9fnB-7IxOK6dNamy6rTbZBbbG2dQHumacAE2VreNLkIIKsUBTh-lL_Iq9Gwe00-L13tls6-r2i7E_v_0I6TvVm9aqWKz2w9i5QYVF-RnDhN6mn8wOvVEPk3uN6gM-urlPk8vXry7Pt1n14c3b802V6YKRKSvrWq05Cg1AANdspwssqdLACApGFcNaAYWGcL1rCNRMEy44YFOXJTZFfpo8P9iO3l3PsQU5mKCx75VFNwcJBaO05FCWEX36F3rlZm9jcxI4z2leEjiiWtWjNLZxk1d6MZWbXMTlFJyxSJ39g4qnxsFoZ7Ex8f-W4NmRoEPVT11w_TzFdYTbIBxA7V0IHhs5ejMov5dA5JITeciJjAK55ETSqHlyM9m8G7D-o_gdjAjQAxBiybboj0b_r-svuELEcg</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Weiner, A. 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S.</au><au>Berezina, O. V.</au><au>Ovchinnikov, V. S.</au><au>Surovtseva, M. N.</au><au>Voropaeva, E. N.</au><au>Pospelova, T. I.</au><au>Filipenko, M. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Polymorphic Loci in HLA-Region rs2647012 and rs805288 in the Development of Non-Hodgkin’s Malignant Lymphomas in Western Siberia</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>157</volume><issue>2</issue><spage>180</spage><epage>183</epage><pages>180-183</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><coden>BEXBAN</coden><abstract>The data of genome-wide association analysis suggest that human 6p21.3 chromosomal region (localization of
HLA
genes) contains polymorphic loci infl uencing the risk of developing non-Hodgkin’s lymphomas. We analyzed association of rs2647012 and rs805288 loci with the risk for non-Hodgkin’s malignant lymphomas in the population of Western Siberia. Allele and genotype frequencies were determined in the group of 298 patients and in the control group including 551 individuals. Subgroups of diffuse large B-cell lymphoma (86 patients) and follicular lymphoma (25 patients) were analyzed separately. An association of rs2647012 А/А genotype with increased risk of the disease (OR = 2.78,
p
= 0.002) was detected in the subgroup of diffuse large B-cell lymphoma.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24958370</pmid><doi>10.1007/s10517-014-2520-2</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-4888 |
| ispartof | Bulletin of experimental biology and medicine, 2014-06, Vol.157 (2), p.180-183 |
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| subjects | Adult Aged Alleles B cells Biomedical and Life Sciences Biomedicine Cell Biology Female General Pathology and Pathophysiology Genome-Wide Association Study - methods Genomes Genomics Genotype Humans Internal Medicine Laboratory Medicine Lymphoma, Non-Hodgkin - genetics Male Middle Aged Non-Hodgkin's lymphomas Pathology Polymorphism, Genetic - genetics Siberia |
| title | Role of Polymorphic Loci in HLA-Region rs2647012 and rs805288 in the Development of Non-Hodgkin’s Malignant Lymphomas in Western Siberia |
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