Performance of the BODE index in patients with α1-antitrypsin deficiency-related COPD
The BODE (body mass index, airflow obstruction, dyspnoea and exercise capacity) index is used to decide on referral and transplantation of patients with chronic obstructive pulmonary disease (COPD). The BODE index has not been validated in patients with α1-antitrypsin deficiency, who account for 15%...
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| Veröffentlicht in: | The European respiratory journal 2014-07, Vol.44 (1), p.78-86 |
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| creator | THABUT, Gabriel MORNEX, Jean-François PISON, Christophe CUVELIER, Antoine BALDUYCK, Malika PUJAZON, Marie-Christine FOURNIER, Michel AITILALNE, Brahim PORCHER, Raphaël |
| description | The BODE (body mass index, airflow obstruction, dyspnoea and exercise capacity) index is used to decide on referral and transplantation of patients with chronic obstructive pulmonary disease (COPD). The BODE index has not been validated in patients with α1-antitrypsin deficiency, who account for 15% of COPD patients undergoing lung transplantation. We sought to validate the BODE index in α1-antitrypsin deficiency-related COPD. We assessed the prognostic value of the BODE index in 191 patients followed from 2006 to 2012 in a French prospective cohort of patients with α1-antitrypsin deficiency. 20 patients died during follow-up and 22 underwent lung transplantation. Survival (95% CI) was 93.0% (91.7-94.3%) at 3 years and 76.0% (72.9-79.1%) at 5 years. The 3-year survival was 97.4% (96.6-98.2%), 98.0% (96.7-99.3%), 87.7% (84.5-90.9%) and 75.3% (66.0-84.6%) for patients with BODE index 0-2, 3-4, 5-6 and 7-10, respectively. Survival discrimination of the BODE index was better than with both forced expiratory volume in 1 s and Global Initiative for Chronic Obstructive Lung Disease classification. Regarding calibration, expected survival by BODE index was noticeably lower than observed survival. The BODE index showed very good survival discrimination in patients with α1-antitrypsin deficiency-related COPD. Larger studies are needed to support its use to drive patient referral for lung transplantation. |
| doi_str_mv | 10.1183/09031936.00168113 |
| format | Article |
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The BODE index has not been validated in patients with α1-antitrypsin deficiency, who account for 15% of COPD patients undergoing lung transplantation. We sought to validate the BODE index in α1-antitrypsin deficiency-related COPD. We assessed the prognostic value of the BODE index in 191 patients followed from 2006 to 2012 in a French prospective cohort of patients with α1-antitrypsin deficiency. 20 patients died during follow-up and 22 underwent lung transplantation. Survival (95% CI) was 93.0% (91.7-94.3%) at 3 years and 76.0% (72.9-79.1%) at 5 years. The 3-year survival was 97.4% (96.6-98.2%), 98.0% (96.7-99.3%), 87.7% (84.5-90.9%) and 75.3% (66.0-84.6%) for patients with BODE index 0-2, 3-4, 5-6 and 7-10, respectively. Survival discrimination of the BODE index was better than with both forced expiratory volume in 1 s and Global Initiative for Chronic Obstructive Lung Disease classification. Regarding calibration, expected survival by BODE index was noticeably lower than observed survival. The BODE index showed very good survival discrimination in patients with α1-antitrypsin deficiency-related COPD. Larger studies are needed to support its use to drive patient referral for lung transplantation.</description><identifier>ISSN: 0903-1936</identifier><identifier>EISSN: 1399-3003</identifier><identifier>DOI: 10.1183/09031936.00168113</identifier><identifier>PMID: 24525449</identifier><language>eng</language><publisher>Leeds: Maney</publisher><subject>Adult ; Aged ; alpha 1-Antitrypsin Deficiency - complications ; alpha 1-Antitrypsin Deficiency - diagnosis ; alpha 1-Antitrypsin Deficiency - mortality ; Area Under Curve ; Biological and medical sciences ; Calibration ; Chronic obstructive pulmonary disease, asthma ; Emphysema - complications ; Emphysema - diagnosis ; Emphysema - mortality ; Errors of metabolism ; Female ; France ; Humans ; Lung Transplantation ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged ; Pneumology ; Probability ; Prognosis ; Prospective Studies ; Proteins and glycoproteins ; Pulmonary Disease, Chronic Obstructive - complications ; Pulmonary Disease, Chronic Obstructive - diagnosis ; Pulmonary Disease, Chronic Obstructive - mortality ; ROC Curve ; Severity of Illness Index ; Software ; Treatment Outcome</subject><ispartof>The European respiratory journal, 2014-07, Vol.44 (1), p.78-86</ispartof><rights>2015 INIST-CNRS</rights><rights>ERS 2014.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28535558$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24525449$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>THABUT, Gabriel</creatorcontrib><creatorcontrib>MORNEX, Jean-François</creatorcontrib><creatorcontrib>PISON, Christophe</creatorcontrib><creatorcontrib>CUVELIER, Antoine</creatorcontrib><creatorcontrib>BALDUYCK, Malika</creatorcontrib><creatorcontrib>PUJAZON, Marie-Christine</creatorcontrib><creatorcontrib>FOURNIER, Michel</creatorcontrib><creatorcontrib>AITILALNE, Brahim</creatorcontrib><creatorcontrib>PORCHER, Raphaël</creatorcontrib><title>Performance of the BODE index in patients with α1-antitrypsin deficiency-related COPD</title><title>The European respiratory journal</title><addtitle>Eur Respir J</addtitle><description>The BODE (body mass index, airflow obstruction, dyspnoea and exercise capacity) index is used to decide on referral and transplantation of patients with chronic obstructive pulmonary disease (COPD). The BODE index has not been validated in patients with α1-antitrypsin deficiency, who account for 15% of COPD patients undergoing lung transplantation. We sought to validate the BODE index in α1-antitrypsin deficiency-related COPD. We assessed the prognostic value of the BODE index in 191 patients followed from 2006 to 2012 in a French prospective cohort of patients with α1-antitrypsin deficiency. 20 patients died during follow-up and 22 underwent lung transplantation. Survival (95% CI) was 93.0% (91.7-94.3%) at 3 years and 76.0% (72.9-79.1%) at 5 years. The 3-year survival was 97.4% (96.6-98.2%), 98.0% (96.7-99.3%), 87.7% (84.5-90.9%) and 75.3% (66.0-84.6%) for patients with BODE index 0-2, 3-4, 5-6 and 7-10, respectively. Survival discrimination of the BODE index was better than with both forced expiratory volume in 1 s and Global Initiative for Chronic Obstructive Lung Disease classification. Regarding calibration, expected survival by BODE index was noticeably lower than observed survival. The BODE index showed very good survival discrimination in patients with α1-antitrypsin deficiency-related COPD. Larger studies are needed to support its use to drive patient referral for lung transplantation.</description><subject>Adult</subject><subject>Aged</subject><subject>alpha 1-Antitrypsin Deficiency - complications</subject><subject>alpha 1-Antitrypsin Deficiency - diagnosis</subject><subject>alpha 1-Antitrypsin Deficiency - mortality</subject><subject>Area Under Curve</subject><subject>Biological and medical sciences</subject><subject>Calibration</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Emphysema - complications</subject><subject>Emphysema - diagnosis</subject><subject>Emphysema - mortality</subject><subject>Errors of metabolism</subject><subject>Female</subject><subject>France</subject><subject>Humans</subject><subject>Lung Transplantation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Pneumology</subject><subject>Probability</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Proteins and glycoproteins</subject><subject>Pulmonary Disease, Chronic Obstructive - complications</subject><subject>Pulmonary Disease, Chronic Obstructive - diagnosis</subject><subject>Pulmonary Disease, Chronic Obstructive - mortality</subject><subject>ROC Curve</subject><subject>Severity of Illness Index</subject><subject>Software</subject><subject>Treatment Outcome</subject><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0EtOwzAQBmALgWgpHIANygaJTcDjR5wsoS0PqVK7qNhGjjNWjfIidgU9FhfhTKSiiM2MNP-nWfyEXAK9BUj5Hc0oh4wnt5RCkgLwIzIGnmUxp5Qfk_E-j_dgRM68f9srweGUjJiQTAqRjcnrCnvb9rVuDEatjcIGo4flbB65psTPYUadDg6b4KMPFzbR9xfEugku9LvOD2mJ1pkhN7u4x0oHLKPpcjU7JydWVx4vDntC1o_z9fQ5XiyfXqb3i7hLkywGSMCkCpQtWalkWlhkQkGhmCxQa2oEp8wypkWhsMQypcCYoDxRargZyyfk5vdt17fvW_Qhr503WFW6wXbrc5CCsSxRnA_06kC3RY1l3vWu1v0u_6tiANcHoL3Rle2HSpz_d6nkUsqU_wDKXWy6</recordid><startdate>201407</startdate><enddate>201407</enddate><creator>THABUT, Gabriel</creator><creator>MORNEX, Jean-François</creator><creator>PISON, Christophe</creator><creator>CUVELIER, Antoine</creator><creator>BALDUYCK, Malika</creator><creator>PUJAZON, Marie-Christine</creator><creator>FOURNIER, Michel</creator><creator>AITILALNE, Brahim</creator><creator>PORCHER, Raphaël</creator><general>Maney</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201407</creationdate><title>Performance of the BODE index in patients with α1-antitrypsin deficiency-related COPD</title><author>THABUT, Gabriel ; MORNEX, Jean-François ; PISON, Christophe ; CUVELIER, Antoine ; BALDUYCK, Malika ; PUJAZON, Marie-Christine ; FOURNIER, Michel ; AITILALNE, Brahim ; PORCHER, Raphaël</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p869-1161c8717fd2d758bfe2471b725beaa0c4302f22a4b7eded801224036772a4cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>alpha 1-Antitrypsin Deficiency - complications</topic><topic>alpha 1-Antitrypsin Deficiency - diagnosis</topic><topic>alpha 1-Antitrypsin Deficiency - mortality</topic><topic>Area Under Curve</topic><topic>Biological and medical sciences</topic><topic>Calibration</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Emphysema - complications</topic><topic>Emphysema - diagnosis</topic><topic>Emphysema - mortality</topic><topic>Errors of metabolism</topic><topic>Female</topic><topic>France</topic><topic>Humans</topic><topic>Lung Transplantation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Pneumology</topic><topic>Probability</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Proteins and glycoproteins</topic><topic>Pulmonary Disease, Chronic Obstructive - complications</topic><topic>Pulmonary Disease, Chronic Obstructive - diagnosis</topic><topic>Pulmonary Disease, Chronic Obstructive - mortality</topic><topic>ROC Curve</topic><topic>Severity of Illness Index</topic><topic>Software</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>THABUT, Gabriel</creatorcontrib><creatorcontrib>MORNEX, Jean-François</creatorcontrib><creatorcontrib>PISON, Christophe</creatorcontrib><creatorcontrib>CUVELIER, Antoine</creatorcontrib><creatorcontrib>BALDUYCK, Malika</creatorcontrib><creatorcontrib>PUJAZON, Marie-Christine</creatorcontrib><creatorcontrib>FOURNIER, Michel</creatorcontrib><creatorcontrib>AITILALNE, Brahim</creatorcontrib><creatorcontrib>PORCHER, Raphaël</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The European respiratory journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>THABUT, Gabriel</au><au>MORNEX, Jean-François</au><au>PISON, Christophe</au><au>CUVELIER, Antoine</au><au>BALDUYCK, Malika</au><au>PUJAZON, Marie-Christine</au><au>FOURNIER, Michel</au><au>AITILALNE, Brahim</au><au>PORCHER, Raphaël</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Performance of the BODE index in patients with α1-antitrypsin deficiency-related COPD</atitle><jtitle>The European respiratory journal</jtitle><addtitle>Eur Respir J</addtitle><date>2014-07</date><risdate>2014</risdate><volume>44</volume><issue>1</issue><spage>78</spage><epage>86</epage><pages>78-86</pages><issn>0903-1936</issn><eissn>1399-3003</eissn><abstract>The BODE (body mass index, airflow obstruction, dyspnoea and exercise capacity) index is used to decide on referral and transplantation of patients with chronic obstructive pulmonary disease (COPD). The BODE index has not been validated in patients with α1-antitrypsin deficiency, who account for 15% of COPD patients undergoing lung transplantation. We sought to validate the BODE index in α1-antitrypsin deficiency-related COPD. We assessed the prognostic value of the BODE index in 191 patients followed from 2006 to 2012 in a French prospective cohort of patients with α1-antitrypsin deficiency. 20 patients died during follow-up and 22 underwent lung transplantation. Survival (95% CI) was 93.0% (91.7-94.3%) at 3 years and 76.0% (72.9-79.1%) at 5 years. The 3-year survival was 97.4% (96.6-98.2%), 98.0% (96.7-99.3%), 87.7% (84.5-90.9%) and 75.3% (66.0-84.6%) for patients with BODE index 0-2, 3-4, 5-6 and 7-10, respectively. Survival discrimination of the BODE index was better than with both forced expiratory volume in 1 s and Global Initiative for Chronic Obstructive Lung Disease classification. Regarding calibration, expected survival by BODE index was noticeably lower than observed survival. The BODE index showed very good survival discrimination in patients with α1-antitrypsin deficiency-related COPD. Larger studies are needed to support its use to drive patient referral for lung transplantation.</abstract><cop>Leeds</cop><pub>Maney</pub><pmid>24525449</pmid><doi>10.1183/09031936.00168113</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Aged alpha 1-Antitrypsin Deficiency - complications alpha 1-Antitrypsin Deficiency - diagnosis alpha 1-Antitrypsin Deficiency - mortality Area Under Curve Biological and medical sciences Calibration Chronic obstructive pulmonary disease, asthma Emphysema - complications Emphysema - diagnosis Emphysema - mortality Errors of metabolism Female France Humans Lung Transplantation Male Medical sciences Metabolic diseases Middle Aged Pneumology Probability Prognosis Prospective Studies Proteins and glycoproteins Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary Disease, Chronic Obstructive - mortality ROC Curve Severity of Illness Index Software Treatment Outcome |
| title | Performance of the BODE index in patients with α1-antitrypsin deficiency-related COPD |
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