The PI3K/AKT/mTOR pathway is activated in gastric cancer with potential prognostic and predictive significance

Signaling pathway alterations are important in the development of gastric cancer (GC). Deregulation of the PI3K/AKT/mTOR pathway plays a crucial role in the regulation of multiple cellular functions including cell growth, proliferation, metabolism, and angiogenesis. Our goal was to assess expression...

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Veröffentlicht in:	Virchows Archiv : an international journal of pathology 2014-07, Vol.465 (1), p.25-33
Hauptverfasser:	Tapia, Oscar, Riquelme, Ismael, Leal, Pamela, Sandoval, Alejandra, Aedo, Susana, Weber, Helga, Letelier, Pablo, Bellolio, Enrique, Villaseca, Miguel, Garcia, Patricia, Roa, Juan Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - biosynthesis Aged Case-Control Studies Deregulation Female Humans Kaplan-Meier Estimate Lymphatic Metastasis - physiopathology Male Medicine Medicine & Public Health Middle Aged Original Article Pathology Phosphatidylinositol 3-Kinases - metabolism Phosphoproteins - biosynthesis Prognosis Proto-Oncogene Proteins c-akt - metabolism Signal Transduction Stomach Neoplasms - mortality Stomach Neoplasms - pathology Stomach Neoplasms - physiopathology TOR Serine-Threonine Kinases - metabolism Tumors
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