Incorporation of E-5-(2-halovinyl)-2'-deoxyuridines into deoxyribonucleic acids of herpes simplex virus type 1-infected cells

E-5-(2-Bromovinyl)-2'-deoxyuridine (BrvdUrd) and E-5-(2-iodovinyl)-2'-deoxyuridine (IvdUrd) are among the most potent and selective inhibitors of herpes simplex virus type 1 (HSV-1) replication. To elucidate the site of inhibition, we examined whether the halovinyl analogs are incorporated...

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Veröffentlicht in:	The Journal of biological chemistry 1982-01, Vol.257 (2), p.603-606
Hauptverfasser:	ALLAUDEEN, H. S, CHEN, M. S, LEE, J. J, DE CLERCQ, E, PRUSOFF, W. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bromodeoxyuridine - analogs & derivatives Bromodeoxyuridine - metabolism Cell Line Cell Transformation, Viral Deoxyuridine - analogs & derivatives Deoxyuridine - metabolism DNA Polymerase II - metabolism DNA Replication DNA, Viral - genetics Fundamental and applied biological sciences. Psychology Halogens - metabolism herpes simplex virus 1 Idoxuridine - analogs & derivatives Idoxuridine - metabolism Kidney Microbiology Simplexvirus - genetics Structure-Activity Relationship Vinyl Compounds - metabolism Virology Virus Replication
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