Overexpression of N-acetylglucosaminyltransferases III and V in human melanoma cells. Implications for MCAM N-glycosylation

An important role in cancer pathogenesis is attributed to N-glycans with “bisecting” N-acetylglucosamine and beta1-6 branches but the exact mechanisms still remain to be elucidated. Two structures are formed by Golgi beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (EC = 2.4.1.1...

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Veröffentlicht in:	Biochimie 2014-08, Vol.103, p.37-49
Hauptverfasser:	Bubka, Monika, Link-Lenczowski, Paweł, Janik, Marcelina, Pocheć, Ewa, Lityńska, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Activity assay Acyltransferases - genetics Acyltransferases - metabolism CD146 Antigen - metabolism Cell Line, Tumor Cell Movement Cell Survival Endothelial Cells - pathology Gene Expression Glycosylation Glycosyltransferases Humans MCAM Melanoma Melanoma - pathology N-Acetylglucosaminyltransferases - genetics N-Acetylglucosaminyltransferases - metabolism N-glycosylation Polysaccharides - metabolism Transendothelial migration Transfection Up-Regulation
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