Longitudinal features of STIR bright signal in FSHD
Magnetic resonance imaging of muscle shows short tau-inversion recovery (STIR) brightness in autosomal dominant facioscapulohumeral muscular dystrophy (FSHD1) suggestive of active inflammation/injury. We measured the longitudinal stability/progression of this potential disease biomarker. Nine subjec...
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| Veröffentlicht in: | Muscle & nerve 2014-02, Vol.49 (2), p.257-260 |
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| container_title | Muscle & nerve |
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| creator | Friedman, Seth D Poliachik, Sandra L Otto, Randolph K Carter, Gregory T Budech, Christopher B Bird, Thomas D Miller, Daniel G Shaw, Dennis W W |
| description | Magnetic resonance imaging of muscle shows short tau-inversion recovery (STIR) brightness in autosomal dominant facioscapulohumeral muscular dystrophy (FSHD1) suggestive of active inflammation/injury. We measured the longitudinal stability/progression of this potential disease biomarker.
Nine subjects underwent calf MRI imaging over 2 years. Two radiologists evaluated qualitative muscle changes.
In 3/9 subjects, calf muscles demonstrated moderate/severe STIR hyperintensity at Time 1 that had progressed to fatty replacement 2 years later (Time 2). In the remaining subjects, moderate/severe muscle STIR abnormalities, when present, were consistent between exams. Mild STIR+ elevations had roughly similar patterns between exams.
Moderate/severe STIR hyperintensities often foreshadow fatty replacement over a 2-year interval. Whether longer time courses are required to observe muscle degeneration and fatty replacement in some subjects remains to be explored. |
| doi_str_mv | 10.1002/mus.23911 |
| format | Article |
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Nine subjects underwent calf MRI imaging over 2 years. Two radiologists evaluated qualitative muscle changes.
In 3/9 subjects, calf muscles demonstrated moderate/severe STIR hyperintensity at Time 1 that had progressed to fatty replacement 2 years later (Time 2). In the remaining subjects, moderate/severe muscle STIR abnormalities, when present, were consistent between exams. Mild STIR+ elevations had roughly similar patterns between exams.
Moderate/severe STIR hyperintensities often foreshadow fatty replacement over a 2-year interval. Whether longer time courses are required to observe muscle degeneration and fatty replacement in some subjects remains to be explored.</description><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.23911</identifier><identifier>PMID: 23720194</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aged ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Muscular Dystrophy, Facioscapulohumeral - diagnosis</subject><ispartof>Muscle & nerve, 2014-02, Vol.49 (2), p.257-260</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23720194$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Friedman, Seth D</creatorcontrib><creatorcontrib>Poliachik, Sandra L</creatorcontrib><creatorcontrib>Otto, Randolph K</creatorcontrib><creatorcontrib>Carter, Gregory T</creatorcontrib><creatorcontrib>Budech, Christopher B</creatorcontrib><creatorcontrib>Bird, Thomas D</creatorcontrib><creatorcontrib>Miller, Daniel G</creatorcontrib><creatorcontrib>Shaw, Dennis W W</creatorcontrib><title>Longitudinal features of STIR bright signal in FSHD</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>Magnetic resonance imaging of muscle shows short tau-inversion recovery (STIR) brightness in autosomal dominant facioscapulohumeral muscular dystrophy (FSHD1) suggestive of active inflammation/injury. We measured the longitudinal stability/progression of this potential disease biomarker.
Nine subjects underwent calf MRI imaging over 2 years. Two radiologists evaluated qualitative muscle changes.
In 3/9 subjects, calf muscles demonstrated moderate/severe STIR hyperintensity at Time 1 that had progressed to fatty replacement 2 years later (Time 2). In the remaining subjects, moderate/severe muscle STIR abnormalities, when present, were consistent between exams. Mild STIR+ elevations had roughly similar patterns between exams.
Moderate/severe STIR hyperintensities often foreshadow fatty replacement over a 2-year interval. Whether longer time courses are required to observe muscle degeneration and fatty replacement in some subjects remains to be explored.</description><subject>Adult</subject><subject>Aged</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscular Dystrophy, Facioscapulohumeral - diagnosis</subject><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j71OwzAYRS0kREth4AWQR5YU25_t2CMqlFaKhETLHDmxHYzyU-J44O1bRJnucI_O1UXojpIlJYQ9dikuGWhKL9CcEp1nXGg1Q9cxfhFCqJL5FZoxyBmhms8RFEPfhCnZ0JsWe2emNLqIB493--07rsbQfE44hua3Dj1e7zbPN-jSmza623Mu0Mf6Zb_aZMXb63b1VGQHRumUaebNaU4IAGYsUxaElqKuPQFdOcsr50HmSlsPTEtpwHvOwOSGK-olE7BAD3_ewzh8Jxensguxdm1rejekWFLBGSGcgzqh92c0VZ2z5WEMnRl_yv-jcATx10_U</recordid><startdate>201402</startdate><enddate>201402</enddate><creator>Friedman, Seth D</creator><creator>Poliachik, Sandra L</creator><creator>Otto, Randolph K</creator><creator>Carter, Gregory T</creator><creator>Budech, Christopher B</creator><creator>Bird, Thomas D</creator><creator>Miller, Daniel G</creator><creator>Shaw, Dennis W W</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201402</creationdate><title>Longitudinal features of STIR bright signal in FSHD</title><author>Friedman, Seth D ; Poliachik, Sandra L ; Otto, Randolph K ; Carter, Gregory T ; Budech, Christopher B ; Bird, Thomas D ; Miller, Daniel G ; Shaw, Dennis W W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-92fa86755332ad28d35965ccf039bed4bef36789df32966a3ff423a7a481f6253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscular Dystrophy, Facioscapulohumeral - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Friedman, Seth D</creatorcontrib><creatorcontrib>Poliachik, Sandra L</creatorcontrib><creatorcontrib>Otto, Randolph K</creatorcontrib><creatorcontrib>Carter, Gregory T</creatorcontrib><creatorcontrib>Budech, Christopher B</creatorcontrib><creatorcontrib>Bird, Thomas D</creatorcontrib><creatorcontrib>Miller, Daniel G</creatorcontrib><creatorcontrib>Shaw, Dennis W W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Friedman, Seth D</au><au>Poliachik, Sandra L</au><au>Otto, Randolph K</au><au>Carter, Gregory T</au><au>Budech, Christopher B</au><au>Bird, Thomas D</au><au>Miller, Daniel G</au><au>Shaw, Dennis W W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal features of STIR bright signal in FSHD</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2014-02</date><risdate>2014</risdate><volume>49</volume><issue>2</issue><spage>257</spage><epage>260</epage><pages>257-260</pages><eissn>1097-4598</eissn><abstract>Magnetic resonance imaging of muscle shows short tau-inversion recovery (STIR) brightness in autosomal dominant facioscapulohumeral muscular dystrophy (FSHD1) suggestive of active inflammation/injury. We measured the longitudinal stability/progression of this potential disease biomarker.
Nine subjects underwent calf MRI imaging over 2 years. Two radiologists evaluated qualitative muscle changes.
In 3/9 subjects, calf muscles demonstrated moderate/severe STIR hyperintensity at Time 1 that had progressed to fatty replacement 2 years later (Time 2). In the remaining subjects, moderate/severe muscle STIR abnormalities, when present, were consistent between exams. Mild STIR+ elevations had roughly similar patterns between exams.
Moderate/severe STIR hyperintensities often foreshadow fatty replacement over a 2-year interval. Whether longer time courses are required to observe muscle degeneration and fatty replacement in some subjects remains to be explored.</abstract><cop>United States</cop><pmid>23720194</pmid><doi>10.1002/mus.23911</doi><tpages>4</tpages></addata></record> |
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| ispartof | Muscle & nerve, 2014-02, Vol.49 (2), p.257-260 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Female Humans Magnetic Resonance Imaging Male Middle Aged Muscular Dystrophy, Facioscapulohumeral - diagnosis |
| title | Longitudinal features of STIR bright signal in FSHD |
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