Progression of autoimmune hepatitis is mediated by IL‐18‐producing dendritic cells and hepatic CXCL9 expression in mice

Clinical manifestations of autoimmune hepatitis (AIH) range from mild chronic to acute, sometimes fulminant hepatitis. However, it is unknown how the progression to fatal hepatitis occurs. We developed a mouse model of fatal AIH by inducing a concurrent loss of forkhead box P3+ regulatory T cells an...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2014-07, Vol.60 (1), p.224-236
Hauptverfasser:	Ikeda, Aki, Aoki, Nobuhiro, Kido, Masahiro, Iwamoto, Satoru, Nishiura, Hisayo, Maruoka, Ryutaro, Chiba, Tsutomu, Watanabe, Norihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Cell Differentiation - immunology Chemokine CXCL9 - immunology Chemokine CXCL9 - metabolism Chemokines Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - pathology Disease Models, Animal Female Hepatitis, Autoimmune - immunology Hepatitis, Autoimmune - pathology Hepatology Interferon-gamma - immunology Interferon-gamma - metabolism Interleukin-18 - immunology Interleukin-18 - metabolism Ligands Liver - immunology Liver - metabolism Liver - pathology Liver Failure, Acute - immunology Liver Failure, Acute - pathology Lymphocytes Macrophages - immunology Macrophages - pathology Male Mice Mice, Inbred BALB C Mice, Knockout Programmed Cell Death 1 Receptor - genetics Receptors, CXCR3 - immunology Receptors, CXCR3 - metabolism Rodents Signal Transduction - immunology Spleen T-Box Domain Proteins - immunology T-Box Domain Proteins - metabolism Thymectomy
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