Chlorpyrifos: A 13-week nose-only vapor inhalation study in Fischer 344 rats
Fischer 344 rats were exposed by the nose-only inhalation route to chlorpyrifos vapors at concentrations of 0, 5.2, 10.3, or 20.6 ppb, 6 hr/day, 5 days/week for 13 weeks. The exposure concentrations were limited by the low vapor pressure of chlorpyrifos (theoretical maximum vapor concentration of 25...
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| Veröffentlicht in: | Fundamental and applied toxicology 1989-10, Vol.13 (3), p.616-618 |
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| container_title | Fundamental and applied toxicology |
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| creator | Corley, Richard A. Calhoun, Linda L. Dittenber, Dean A. Lomax, Larry G. Landry, Timothy D. |
| description | Fischer 344 rats were exposed by the nose-only inhalation route to chlorpyrifos vapors at concentrations of 0, 5.2, 10.3, or 20.6 ppb, 6 hr/day, 5 days/week for 13 weeks. The exposure concentrations were limited by the low vapor pressure of chlorpyrifos (theoretical maximum vapor concentration of 25 ppb at 25°C). No treatment-related signs of toxicity or changes in body weights were detected during the course of the study. Urinalysis, hematology, clinical chemistry, organ weights, gross pathologic, and histopathologic evaluations were performed at the end of the study with no treatment-related effects observed. In addition, no differences from controls were noted in plasma, red blood cell, or brain cholinesterase activities. The results of this study indicate that the no-observed-effect level for chlorpyrifos vapor was the highest attainable concentration, 20.6 ppb, in male and female Fischer 344 rats. |
| doi_str_mv | 10.1016/0272-0590(89)90299-6 |
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The exposure concentrations were limited by the low vapor pressure of chlorpyrifos (theoretical maximum vapor concentration of 25 ppb at 25°C). No treatment-related signs of toxicity or changes in body weights were detected during the course of the study. Urinalysis, hematology, clinical chemistry, organ weights, gross pathologic, and histopathologic evaluations were performed at the end of the study with no treatment-related effects observed. In addition, no differences from controls were noted in plasma, red blood cell, or brain cholinesterase activities. The results of this study indicate that the no-observed-effect level for chlorpyrifos vapor was the highest attainable concentration, 20.6 ppb, in male and female Fischer 344 rats.</description><identifier>ISSN: 0272-0590</identifier><identifier>EISSN: 1095-6832</identifier><identifier>DOI: 10.1016/0272-0590(89)90299-6</identifier><identifier>PMID: 2482212</identifier><identifier>CODEN: FAATDF</identifier><language>eng</language><publisher>Boston, MA: Elsevier Science (USA)</publisher><subject>Administration, Inhalation ; Animals ; Biological and medical sciences ; Brain - drug effects ; Brain - enzymology ; Chlorpyrifos - administration & dosage ; Chlorpyrifos - toxicity ; Cholinesterases - blood ; Cholinesterases - metabolism ; COMPOSE ORGANOPHOSPHORE ; COMPUESTO ORGANICO DEL FOSFORO ; Erythrocytes - drug effects ; Erythrocytes - enzymology ; Female ; INSECTICIDAS ; INSECTICIDE ; INSECTICIDES ; Male ; Medical sciences ; ORGANOPHOSPHORUS COMPOUNDS ; PESTICIDE ; PESTICIDES ; Pesticides, fertilizers and other agrochemicals toxicology ; PLAGUICIDAS ; RAT ; RATA ; RATS ; Rats, Inbred F344 ; Sex Factors ; TOXICIDAD ; TOXICITE ; TOXICITY ; Toxicology</subject><ispartof>Fundamental and applied toxicology, 1989-10, Vol.13 (3), p.616-618</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6685948$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2482212$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Corley, Richard A.</creatorcontrib><creatorcontrib>Calhoun, Linda L.</creatorcontrib><creatorcontrib>Dittenber, Dean A.</creatorcontrib><creatorcontrib>Lomax, Larry G.</creatorcontrib><creatorcontrib>Landry, Timothy D.</creatorcontrib><title>Chlorpyrifos: A 13-week nose-only vapor inhalation study in Fischer 344 rats</title><title>Fundamental and applied toxicology</title><addtitle>Fundam Appl Toxicol</addtitle><description>Fischer 344 rats were exposed by the nose-only inhalation route to chlorpyrifos vapors at concentrations of 0, 5.2, 10.3, or 20.6 ppb, 6 hr/day, 5 days/week for 13 weeks. The exposure concentrations were limited by the low vapor pressure of chlorpyrifos (theoretical maximum vapor concentration of 25 ppb at 25°C). No treatment-related signs of toxicity or changes in body weights were detected during the course of the study. Urinalysis, hematology, clinical chemistry, organ weights, gross pathologic, and histopathologic evaluations were performed at the end of the study with no treatment-related effects observed. In addition, no differences from controls were noted in plasma, red blood cell, or brain cholinesterase activities. The results of this study indicate that the no-observed-effect level for chlorpyrifos vapor was the highest attainable concentration, 20.6 ppb, in male and female Fischer 344 rats.</description><subject>Administration, Inhalation</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - enzymology</subject><subject>Chlorpyrifos - administration & dosage</subject><subject>Chlorpyrifos - toxicity</subject><subject>Cholinesterases - blood</subject><subject>Cholinesterases - metabolism</subject><subject>COMPOSE ORGANOPHOSPHORE</subject><subject>COMPUESTO ORGANICO DEL FOSFORO</subject><subject>Erythrocytes - drug effects</subject><subject>Erythrocytes - enzymology</subject><subject>Female</subject><subject>INSECTICIDAS</subject><subject>INSECTICIDE</subject><subject>INSECTICIDES</subject><subject>Male</subject><subject>Medical sciences</subject><subject>ORGANOPHOSPHORUS COMPOUNDS</subject><subject>PESTICIDE</subject><subject>PESTICIDES</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>PLAGUICIDAS</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>Rats, Inbred F344</subject><subject>Sex Factors</subject><subject>TOXICIDAD</subject><subject>TOXICITE</subject><subject>TOXICITY</subject><subject>Toxicology</subject><issn>0272-0590</issn><issn>1095-6832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kUtrGzEUhUVoSNy0fyCkoEUpyWLaeyWNZtRFIZi8wJBFm7VQ9KjVjkeuNE7xv69cm6wu6Hy6nHMPIRcInxFQfgHWsQZaBZe9ulLAlGrkEZkhqLaRPWdvyOwVOSVvS_kFgNgKOCEnTPSMIZuRxXw5pLze5hhS-UqvKfLmr_e_6ZiKb9I4bOmLWadM47g0g5liGmmZNm5bH-htLHbpM-VC0Gym8o4cBzMU__4wz8jT7c2P-X2zeLx7mF8vGs8FTA3aDnZ2HbctQxnCMzrrUMiAAK0FXq11vTHBSlZ_OGc6w9qKcYFB-MDPyKf93nVOfza-THpVnfhhMKNPm6JrSFRKYQU_HMDN88o7vc5xZfJWH-JX_eNBN8WaIWQz2lheMSn7Vom-Yud7LJikzc9ckafv9eLYIVTx2170NfFL9FkXG_1ovYvZ20m7FDWC3lWmd33oXR-6V_p_ZVryf_w5hCY</recordid><startdate>19891001</startdate><enddate>19891001</enddate><creator>Corley, Richard A.</creator><creator>Calhoun, Linda L.</creator><creator>Dittenber, Dean A.</creator><creator>Lomax, Larry G.</creator><creator>Landry, Timothy D.</creator><general>Elsevier Science (USA)</general><general>Academic Press</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T2</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19891001</creationdate><title>Chlorpyrifos: A 13-week nose-only vapor inhalation study in Fischer 344 rats</title><author>Corley, Richard A. ; Calhoun, Linda L. ; Dittenber, Dean A. ; Lomax, Larry G. ; Landry, Timothy D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e340t-1c700299d3c5216ffb1dcd146f1005c0322178aafc62e34dda7a25ffb341f4ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Administration, Inhalation</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - enzymology</topic><topic>Chlorpyrifos - administration & dosage</topic><topic>Chlorpyrifos - toxicity</topic><topic>Cholinesterases - blood</topic><topic>Cholinesterases - metabolism</topic><topic>COMPOSE ORGANOPHOSPHORE</topic><topic>COMPUESTO ORGANICO DEL FOSFORO</topic><topic>Erythrocytes - drug effects</topic><topic>Erythrocytes - enzymology</topic><topic>Female</topic><topic>INSECTICIDAS</topic><topic>INSECTICIDE</topic><topic>INSECTICIDES</topic><topic>Male</topic><topic>Medical sciences</topic><topic>ORGANOPHOSPHORUS COMPOUNDS</topic><topic>PESTICIDE</topic><topic>PESTICIDES</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>PLAGUICIDAS</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>Rats, Inbred F344</topic><topic>Sex Factors</topic><topic>TOXICIDAD</topic><topic>TOXICITE</topic><topic>TOXICITY</topic><topic>Toxicology</topic><toplevel>online_resources</toplevel><creatorcontrib>Corley, Richard A.</creatorcontrib><creatorcontrib>Calhoun, Linda L.</creatorcontrib><creatorcontrib>Dittenber, Dean A.</creatorcontrib><creatorcontrib>Lomax, Larry G.</creatorcontrib><creatorcontrib>Landry, Timothy D.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Fundamental and applied toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Corley, Richard A.</au><au>Calhoun, Linda L.</au><au>Dittenber, Dean A.</au><au>Lomax, Larry G.</au><au>Landry, Timothy D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chlorpyrifos: A 13-week nose-only vapor inhalation study in Fischer 344 rats</atitle><jtitle>Fundamental and applied toxicology</jtitle><addtitle>Fundam Appl Toxicol</addtitle><date>1989-10-01</date><risdate>1989</risdate><volume>13</volume><issue>3</issue><spage>616</spage><epage>618</epage><pages>616-618</pages><issn>0272-0590</issn><eissn>1095-6832</eissn><coden>FAATDF</coden><abstract>Fischer 344 rats were exposed by the nose-only inhalation route to chlorpyrifos vapors at concentrations of 0, 5.2, 10.3, or 20.6 ppb, 6 hr/day, 5 days/week for 13 weeks. The exposure concentrations were limited by the low vapor pressure of chlorpyrifos (theoretical maximum vapor concentration of 25 ppb at 25°C). No treatment-related signs of toxicity or changes in body weights were detected during the course of the study. Urinalysis, hematology, clinical chemistry, organ weights, gross pathologic, and histopathologic evaluations were performed at the end of the study with no treatment-related effects observed. In addition, no differences from controls were noted in plasma, red blood cell, or brain cholinesterase activities. The results of this study indicate that the no-observed-effect level for chlorpyrifos vapor was the highest attainable concentration, 20.6 ppb, in male and female Fischer 344 rats.</abstract><cop>Boston, MA</cop><cop>San Diego, CA</cop><cop>New York, NY</cop><pub>Elsevier Science (USA)</pub><pmid>2482212</pmid><doi>10.1016/0272-0590(89)90299-6</doi><tpages>3</tpages></addata></record> |
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| source | Oxford University Press Journals Digital Archive legacy; MEDLINE; Alma/SFX Local Collection |
| subjects | Administration, Inhalation Animals Biological and medical sciences Brain - drug effects Brain - enzymology Chlorpyrifos - administration & dosage Chlorpyrifos - toxicity Cholinesterases - blood Cholinesterases - metabolism COMPOSE ORGANOPHOSPHORE COMPUESTO ORGANICO DEL FOSFORO Erythrocytes - drug effects Erythrocytes - enzymology Female INSECTICIDAS INSECTICIDE INSECTICIDES Male Medical sciences ORGANOPHOSPHORUS COMPOUNDS PESTICIDE PESTICIDES Pesticides, fertilizers and other agrochemicals toxicology PLAGUICIDAS RAT RATA RATS Rats, Inbred F344 Sex Factors TOXICIDAD TOXICITE TOXICITY Toxicology |
| title | Chlorpyrifos: A 13-week nose-only vapor inhalation study in Fischer 344 rats |
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