Circulating 25-hydroxyvitamin D serum concentration and total cancer incidence and mortality: A systematic review and meta-analysis
Abstract Objective To conduct a systematic review and meta-analysis of longitudinal studies on the association of 25(OH)D with total cancer incidence and mortality. Method Relevant longitudinal observational studies were identified by systematically searching Ovid Medline, EMBASE, and ISI Web of Kno...
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| Veröffentlicht in: | Preventive medicine 2013-12, Vol.57 (6), p.753-764 |
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| creator | Yin, Lu Ordóñez-Mena, José M Chen, Tianhui Schöttker, Ben Arndt, Volker Brenner, Hermann |
| description | Abstract Objective To conduct a systematic review and meta-analysis of longitudinal studies on the association of 25(OH)D with total cancer incidence and mortality. Method Relevant longitudinal observational studies were identified by systematically searching Ovid Medline, EMBASE, and ISI Web of Knowledge databases. Due to the heterogeneity across studies in categorizing 25(OH)D concentration, all results were recalculated for an increase of 25(OH)D by 50 nmol/L. Results In meta-analyses with random effects models, the summary risk ratios and confidence intervals (RRs (95% CI)) for the association of an increase of 25(OH)D by 50 nmol/L with total cancer incidence (5 studies) and mortality (13 studies) were 0.89 (0.81, 0.97) and 0.83 (0.71, 0.96), respectively. In sex-specific analyses no significant association with total cancer incidence was observed among men or women. A clear inverse association with total cancer mortality was observed among women (0.76 (0.60, 0.98)) but not among men (0.92 (0.65, 1.32)). Large heterogeneity was observed for studies on total cancer mortality (P < 0.01) but not for studies on cancer incidence (P = 0.41). No publication bias was found. Conclusion The meta-analysis suggests a moderate inverse association of 25(OH)D concentration with total cancer incidence and mortality. |
| doi_str_mv | 10.1016/j.ypmed.2013.08.026 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1541987367</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0091743513003186</els_id><sourcerecordid>1461339727</sourcerecordid><originalsourceid>FETCH-LOGICAL-c477t-5ec833c58d013e5a33a676e48d54063361f06aeb083a42d8a7bc578aef5775053</originalsourceid><addsrcrecordid>eNqFkk2LFDEQhoMo7rj6CwTJRfDSbaXT-WjBhWX8hAUP6jlk0tWasT_GJL3aZ_-46Z1ZBC97SpF63lSq3iLkKYOSAZMv9-VyGLAtK2C8BF1CJe-RDYNGFjmE-2QD0LBC1VyckUcx7gEYk1A_JGdVDVwCqzfkz9YHN_c2-fEbrUTxfWnD9Hu59skOfqRvaMQwD9RNo8MxhcxNI7VjS9OUbE-dzfeB-tH5FnN4kxqmkHM-La_oJY1LTDhknaMBrz3-OiKYbGFH2y_Rx8fkQWf7iE9O5zn5-u7tl-2H4urT-4_by6vC1UqlQqDTnDuh29wwCsu5lUpirVtRg-Rcsg6kxR1obuuq1VbtnFDaYieUEiD4OXlxfPcQpp8zxmQGHx32vR1xmqNhomaNVlyqu9FaMs4bVa0oP6IuTDEG7Mwh-MGGxTAwq1Fmb26MMqtRBrTJ7mTVs1OBebfmbjW3zmTg-Qmw0dm-C3nSPv7jVJOb0iv3-shhnlyebzDR-dWK1gd0ybSTv-MjF__pXe9Hn0v-wAXjfppDtil3bGJlwHxed2pdKcYBONOS_wWhv8fn</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1461339727</pqid></control><display><type>article</type><title>Circulating 25-hydroxyvitamin D serum concentration and total cancer incidence and mortality: A systematic review and meta-analysis</title><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Yin, Lu ; Ordóñez-Mena, José M ; Chen, Tianhui ; Schöttker, Ben ; Arndt, Volker ; Brenner, Hermann</creator><creatorcontrib>Yin, Lu ; Ordóñez-Mena, José M ; Chen, Tianhui ; Schöttker, Ben ; Arndt, Volker ; Brenner, Hermann</creatorcontrib><description>Abstract Objective To conduct a systematic review and meta-analysis of longitudinal studies on the association of 25(OH)D with total cancer incidence and mortality. Method Relevant longitudinal observational studies were identified by systematically searching Ovid Medline, EMBASE, and ISI Web of Knowledge databases. Due to the heterogeneity across studies in categorizing 25(OH)D concentration, all results were recalculated for an increase of 25(OH)D by 50 nmol/L. Results In meta-analyses with random effects models, the summary risk ratios and confidence intervals (RRs (95% CI)) for the association of an increase of 25(OH)D by 50 nmol/L with total cancer incidence (5 studies) and mortality (13 studies) were 0.89 (0.81, 0.97) and 0.83 (0.71, 0.96), respectively. In sex-specific analyses no significant association with total cancer incidence was observed among men or women. A clear inverse association with total cancer mortality was observed among women (0.76 (0.60, 0.98)) but not among men (0.92 (0.65, 1.32)). Large heterogeneity was observed for studies on total cancer mortality (P < 0.01) but not for studies on cancer incidence (P = 0.41). No publication bias was found. Conclusion The meta-analysis suggests a moderate inverse association of 25(OH)D concentration with total cancer incidence and mortality.</description><identifier>ISSN: 0091-7435</identifier><identifier>EISSN: 1096-0260</identifier><identifier>DOI: 10.1016/j.ypmed.2013.08.026</identifier><identifier>PMID: 24036014</identifier><identifier>CODEN: PVTMA3</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Biological and medical sciences ; Cancer ; Concentration ; Confidence intervals ; Female ; Heterogeneity ; Humans ; Incidence ; Internal Medicine ; Longitudinal Studies ; Male ; Medical sciences ; Meta-Analysis ; Miscellaneous ; Mortality ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Neoplasms - blood ; Neoplasms - epidemiology ; Neoplasms - mortality ; Prevention and actions ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Random effects ; Risk Factors ; Tumors ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood</subject><ispartof>Preventive medicine, 2013-12, Vol.57 (6), p.753-764</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>2013.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-5ec833c58d013e5a33a676e48d54063361f06aeb083a42d8a7bc578aef5775053</citedby><cites>FETCH-LOGICAL-c477t-5ec833c58d013e5a33a676e48d54063361f06aeb083a42d8a7bc578aef5775053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0091743513003186$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,30977,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27977584$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24036014$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yin, Lu</creatorcontrib><creatorcontrib>Ordóñez-Mena, José M</creatorcontrib><creatorcontrib>Chen, Tianhui</creatorcontrib><creatorcontrib>Schöttker, Ben</creatorcontrib><creatorcontrib>Arndt, Volker</creatorcontrib><creatorcontrib>Brenner, Hermann</creatorcontrib><title>Circulating 25-hydroxyvitamin D serum concentration and total cancer incidence and mortality: A systematic review and meta-analysis</title><title>Preventive medicine</title><addtitle>Prev Med</addtitle><description>Abstract Objective To conduct a systematic review and meta-analysis of longitudinal studies on the association of 25(OH)D with total cancer incidence and mortality. Method Relevant longitudinal observational studies were identified by systematically searching Ovid Medline, EMBASE, and ISI Web of Knowledge databases. Due to the heterogeneity across studies in categorizing 25(OH)D concentration, all results were recalculated for an increase of 25(OH)D by 50 nmol/L. Results In meta-analyses with random effects models, the summary risk ratios and confidence intervals (RRs (95% CI)) for the association of an increase of 25(OH)D by 50 nmol/L with total cancer incidence (5 studies) and mortality (13 studies) were 0.89 (0.81, 0.97) and 0.83 (0.71, 0.96), respectively. In sex-specific analyses no significant association with total cancer incidence was observed among men or women. A clear inverse association with total cancer mortality was observed among women (0.76 (0.60, 0.98)) but not among men (0.92 (0.65, 1.32)). Large heterogeneity was observed for studies on total cancer mortality (P < 0.01) but not for studies on cancer incidence (P = 0.41). No publication bias was found. Conclusion The meta-analysis suggests a moderate inverse association of 25(OH)D concentration with total cancer incidence and mortality.</description><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Concentration</subject><subject>Confidence intervals</subject><subject>Female</subject><subject>Heterogeneity</subject><subject>Humans</subject><subject>Incidence</subject><subject>Internal Medicine</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meta-Analysis</subject><subject>Miscellaneous</subject><subject>Mortality</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Neoplasms - blood</subject><subject>Neoplasms - epidemiology</subject><subject>Neoplasms - mortality</subject><subject>Prevention and actions</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Random effects</subject><subject>Risk Factors</subject><subject>Tumors</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><issn>0091-7435</issn><issn>1096-0260</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqFkk2LFDEQhoMo7rj6CwTJRfDSbaXT-WjBhWX8hAUP6jlk0tWasT_GJL3aZ_-46Z1ZBC97SpF63lSq3iLkKYOSAZMv9-VyGLAtK2C8BF1CJe-RDYNGFjmE-2QD0LBC1VyckUcx7gEYk1A_JGdVDVwCqzfkz9YHN_c2-fEbrUTxfWnD9Hu59skOfqRvaMQwD9RNo8MxhcxNI7VjS9OUbE-dzfeB-tH5FnN4kxqmkHM-La_oJY1LTDhknaMBrz3-OiKYbGFH2y_Rx8fkQWf7iE9O5zn5-u7tl-2H4urT-4_by6vC1UqlQqDTnDuh29wwCsu5lUpirVtRg-Rcsg6kxR1obuuq1VbtnFDaYieUEiD4OXlxfPcQpp8zxmQGHx32vR1xmqNhomaNVlyqu9FaMs4bVa0oP6IuTDEG7Mwh-MGGxTAwq1Fmb26MMqtRBrTJ7mTVs1OBebfmbjW3zmTg-Qmw0dm-C3nSPv7jVJOb0iv3-shhnlyebzDR-dWK1gd0ybSTv-MjF__pXe9Hn0v-wAXjfppDtil3bGJlwHxed2pdKcYBONOS_wWhv8fn</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Yin, Lu</creator><creator>Ordóñez-Mena, José M</creator><creator>Chen, Tianhui</creator><creator>Schöttker, Ben</creator><creator>Arndt, Volker</creator><creator>Brenner, Hermann</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QJ</scope></search><sort><creationdate>20131201</creationdate><title>Circulating 25-hydroxyvitamin D serum concentration and total cancer incidence and mortality: A systematic review and meta-analysis</title><author>Yin, Lu ; Ordóñez-Mena, José M ; Chen, Tianhui ; Schöttker, Ben ; Arndt, Volker ; Brenner, Hermann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-5ec833c58d013e5a33a676e48d54063361f06aeb083a42d8a7bc578aef5775053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Concentration</topic><topic>Confidence intervals</topic><topic>Female</topic><topic>Heterogeneity</topic><topic>Humans</topic><topic>Incidence</topic><topic>Internal Medicine</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Meta-Analysis</topic><topic>Miscellaneous</topic><topic>Mortality</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Neoplasms - blood</topic><topic>Neoplasms - epidemiology</topic><topic>Neoplasms - mortality</topic><topic>Prevention and actions</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Random effects</topic><topic>Risk Factors</topic><topic>Tumors</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yin, Lu</creatorcontrib><creatorcontrib>Ordóñez-Mena, José M</creatorcontrib><creatorcontrib>Chen, Tianhui</creatorcontrib><creatorcontrib>Schöttker, Ben</creatorcontrib><creatorcontrib>Arndt, Volker</creatorcontrib><creatorcontrib>Brenner, Hermann</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>Preventive medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yin, Lu</au><au>Ordóñez-Mena, José M</au><au>Chen, Tianhui</au><au>Schöttker, Ben</au><au>Arndt, Volker</au><au>Brenner, Hermann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating 25-hydroxyvitamin D serum concentration and total cancer incidence and mortality: A systematic review and meta-analysis</atitle><jtitle>Preventive medicine</jtitle><addtitle>Prev Med</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>57</volume><issue>6</issue><spage>753</spage><epage>764</epage><pages>753-764</pages><issn>0091-7435</issn><eissn>1096-0260</eissn><coden>PVTMA3</coden><abstract>Abstract Objective To conduct a systematic review and meta-analysis of longitudinal studies on the association of 25(OH)D with total cancer incidence and mortality. Method Relevant longitudinal observational studies were identified by systematically searching Ovid Medline, EMBASE, and ISI Web of Knowledge databases. Due to the heterogeneity across studies in categorizing 25(OH)D concentration, all results were recalculated for an increase of 25(OH)D by 50 nmol/L. Results In meta-analyses with random effects models, the summary risk ratios and confidence intervals (RRs (95% CI)) for the association of an increase of 25(OH)D by 50 nmol/L with total cancer incidence (5 studies) and mortality (13 studies) were 0.89 (0.81, 0.97) and 0.83 (0.71, 0.96), respectively. In sex-specific analyses no significant association with total cancer incidence was observed among men or women. A clear inverse association with total cancer mortality was observed among women (0.76 (0.60, 0.98)) but not among men (0.92 (0.65, 1.32)). Large heterogeneity was observed for studies on total cancer mortality (P < 0.01) but not for studies on cancer incidence (P = 0.41). No publication bias was found. Conclusion The meta-analysis suggests a moderate inverse association of 25(OH)D concentration with total cancer incidence and mortality.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>24036014</pmid><doi>10.1016/j.ypmed.2013.08.026</doi><tpages>12</tpages></addata></record> |
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| ispartof | Preventive medicine, 2013-12, Vol.57 (6), p.753-764 |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Cancer Concentration Confidence intervals Female Heterogeneity Humans Incidence Internal Medicine Longitudinal Studies Male Medical sciences Meta-Analysis Miscellaneous Mortality Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasms - blood Neoplasms - epidemiology Neoplasms - mortality Prevention and actions Public health. Hygiene Public health. Hygiene-occupational medicine Random effects Risk Factors Tumors Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood |
| title | Circulating 25-hydroxyvitamin D serum concentration and total cancer incidence and mortality: A systematic review and meta-analysis |
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