Treatment adherence in bipolar I and schizoaffective disorder, bipolar type
Abstract Background Poor adherence rates in Bipolar Disorder type I (BDI) and Schizoaffective Disorder, bipolar type (SAD) may be high This study was aimed at comparing the clinical correlates of adherence to treatment and the course of illness in BDI and SAD patients. Methods 75 SAD and 150 BDI DSM...
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| Veröffentlicht in: | Journal of affective disorders 2013-12, Vol.151 (3), p.1003-1008 |
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| creator | Murru, A Pacchiarotti, I Amann, B.L A.M.A., Nivoli Vieta, E Colom, F |
| description | Abstract Background Poor adherence rates in Bipolar Disorder type I (BDI) and Schizoaffective Disorder, bipolar type (SAD) may be high This study was aimed at comparing the clinical correlates of adherence to treatment and the course of illness in BDI and SAD patients. Methods 75 SAD and 150 BDI DSM-IV outpatients were included. Adherence was assessed on the basis of patients’ and care-givers’ reports and serum levels, when available. Socio-demographic, clinical and treatment variables were collected and compared between diagnostic subsamples and then between goodly and poorly adherent patients. Multiple logistic regressions were performed, controlling for diagnostic subsample differences, to identify correlates of adherence in BDI and SAD groups. Results Poor adherence was highly prevalent both in BDI (32%) and in SAD patients (44%), with no significant differences between diagnostic categories. Presence of psychotic symptoms ( p =0.029), higher number of manic relapses ( p |
| doi_str_mv | 10.1016/j.jad.2013.08.026 |
| format | Article |
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Methods 75 SAD and 150 BDI DSM-IV outpatients were included. Adherence was assessed on the basis of patients’ and care-givers’ reports and serum levels, when available. Socio-demographic, clinical and treatment variables were collected and compared between diagnostic subsamples and then between goodly and poorly adherent patients. Multiple logistic regressions were performed, controlling for diagnostic subsample differences, to identify correlates of adherence in BDI and SAD groups. Results Poor adherence was highly prevalent both in BDI (32%) and in SAD patients (44%), with no significant differences between diagnostic categories. Presence of psychotic symptoms ( p =0.029), higher number of manic relapses ( p <0.001), comorbidity with personality disorders ( p =0.002), and lithium therapy ( p =0.003) were associated with poor adherence to treatment. Diagnostic subgroup analyses showed different predictive models, with the BDI poorly adherent subsample being more likely to include comorbid personality and manic recurrences and the SAD poorly adherent subsample being less clinically predictable. Limitations The cross-sectional nature of the study limits de capacity to ascertain the direction of the relationship between certain variables. Conclusions Rates of poor adherence to oral treatments are similar in SAD and BDI. BDI patients with comorbid personality and substance use disorders are likely to be poorly adherent. Treatment adherence may be more difficult to predict in SAD patients.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/j.jad.2013.08.026</identifier><identifier>PMID: 24099884</identifier><identifier>CODEN: JADID7</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Adherence ; Adherence to treatment ; Adherents ; Adult ; Adult and adolescent clinical studies ; Antipsychotic Agents - therapeutic use ; Biological and medical sciences ; Bipolar affective disorder ; Bipolar disorder ; Bipolar Disorder - drug therapy ; Bipolar Disorder - psychology ; Bipolar disorders ; Comorbidity ; Cross-Sectional Studies ; Female ; Humans ; Male ; Medical sciences ; Medication Adherence - psychology ; Medication Adherence - statistics & numerical data ; Miscellaneous ; Mood disorders ; Personality ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Psychotic Disorders - drug therapy ; Psychotic Disorders - psychology ; Schizoaffective disorder ; Schizophrenia</subject><ispartof>Journal of affective disorders, 2013-12, Vol.151 (3), p.1003-1008</ispartof><rights>Elsevier B.V.</rights><rights>2013 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-3a632ddc16382e2fcbb23c4c72fcd4f7106758dd74ec85e413e6024d1ff758a63</citedby><cites>FETCH-LOGICAL-c537t-3a632ddc16382e2fcbb23c4c72fcd4f7106758dd74ec85e413e6024d1ff758a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165032713006605$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,30977,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27932662$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24099884$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murru, A</creatorcontrib><creatorcontrib>Pacchiarotti, I</creatorcontrib><creatorcontrib>Amann, B.L</creatorcontrib><creatorcontrib>A.M.A., Nivoli</creatorcontrib><creatorcontrib>Vieta, E</creatorcontrib><creatorcontrib>Colom, F</creatorcontrib><title>Treatment adherence in bipolar I and schizoaffective disorder, bipolar type</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>Abstract Background Poor adherence rates in Bipolar Disorder type I (BDI) and Schizoaffective Disorder, bipolar type (SAD) may be high This study was aimed at comparing the clinical correlates of adherence to treatment and the course of illness in BDI and SAD patients. Methods 75 SAD and 150 BDI DSM-IV outpatients were included. Adherence was assessed on the basis of patients’ and care-givers’ reports and serum levels, when available. Socio-demographic, clinical and treatment variables were collected and compared between diagnostic subsamples and then between goodly and poorly adherent patients. Multiple logistic regressions were performed, controlling for diagnostic subsample differences, to identify correlates of adherence in BDI and SAD groups. Results Poor adherence was highly prevalent both in BDI (32%) and in SAD patients (44%), with no significant differences between diagnostic categories. Presence of psychotic symptoms ( p =0.029), higher number of manic relapses ( p <0.001), comorbidity with personality disorders ( p =0.002), and lithium therapy ( p =0.003) were associated with poor adherence to treatment. Diagnostic subgroup analyses showed different predictive models, with the BDI poorly adherent subsample being more likely to include comorbid personality and manic recurrences and the SAD poorly adherent subsample being less clinically predictable. Limitations The cross-sectional nature of the study limits de capacity to ascertain the direction of the relationship between certain variables. Conclusions Rates of poor adherence to oral treatments are similar in SAD and BDI. BDI patients with comorbid personality and substance use disorders are likely to be poorly adherent. Treatment adherence may be more difficult to predict in SAD patients.</description><subject>Adherence</subject><subject>Adherence to treatment</subject><subject>Adherents</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Bipolar affective disorder</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - drug therapy</subject><subject>Bipolar Disorder - psychology</subject><subject>Bipolar disorders</subject><subject>Comorbidity</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medication Adherence - psychology</subject><subject>Medication Adherence - statistics & numerical data</subject><subject>Miscellaneous</subject><subject>Mood disorders</subject><subject>Personality</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Psychotic Disorders - drug therapy</subject><subject>Psychotic Disorders - psychology</subject><subject>Schizoaffective disorder</subject><subject>Schizophrenia</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkk2LFDEQhoMo7uzqD_AifRE8bLeV7zTCgix-LC54cD2HTFLNpu3pHpOehfHXm2bGFTzonhLC81aqeIqQFxQaClS96ZvehYYB5Q2YBph6RFZUal4zSfVjsiqMrIEzfUJOc-4BQLUanpITJqBtjREr8vkmoZs3OM6VC7eYcPRYxbFax-00uFRdVW4MVfa38efkug79HO-wCjFPKWA6v-fm_RafkSedGzI-P55n5NuH9zeXn-rrLx-vLt9d115yPdfcKc5C8FRxw5B1fr1m3AuvyzWITlNQWpoQtEBvJArKUQETgXZdeS_hM_L6UHebph87zLPdxOxxGNyI0y5bKgVtjeKyfQDKheFMMfkAlJa-wBj2f1QIZbQArQtKD6hPU84JO7tNcePS3lKwi0Tb2yLRLhItGFsklszLY_ndeoPhPvHbWgFeHQGXvRu65EYf8x9Ot2UktfT59sBhsXEXMdns42I4xFRM2jDFf7Zx8VfaD3GM5cPvuMfcT7s0Fs2W2sws2K_Lti3LRnnZMwWS_wJ9ysxA</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Murru, A</creator><creator>Pacchiarotti, I</creator><creator>Amann, B.L</creator><creator>A.M.A., Nivoli</creator><creator>Vieta, E</creator><creator>Colom, F</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>7QJ</scope></search><sort><creationdate>20131201</creationdate><title>Treatment adherence in bipolar I and schizoaffective disorder, bipolar type</title><author>Murru, A ; Pacchiarotti, I ; Amann, B.L ; A.M.A., Nivoli ; Vieta, E ; Colom, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-3a632ddc16382e2fcbb23c4c72fcd4f7106758dd74ec85e413e6024d1ff758a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adherence</topic><topic>Adherence to treatment</topic><topic>Adherents</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Bipolar affective disorder</topic><topic>Bipolar disorder</topic><topic>Bipolar Disorder - drug therapy</topic><topic>Bipolar Disorder - psychology</topic><topic>Bipolar disorders</topic><topic>Comorbidity</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medication Adherence - psychology</topic><topic>Medication Adherence - statistics & numerical data</topic><topic>Miscellaneous</topic><topic>Mood disorders</topic><topic>Personality</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Psychotic Disorders - drug therapy</topic><topic>Psychotic Disorders - psychology</topic><topic>Schizoaffective disorder</topic><topic>Schizophrenia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murru, A</creatorcontrib><creatorcontrib>Pacchiarotti, I</creatorcontrib><creatorcontrib>Amann, B.L</creatorcontrib><creatorcontrib>A.M.A., Nivoli</creatorcontrib><creatorcontrib>Vieta, E</creatorcontrib><creatorcontrib>Colom, F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murru, A</au><au>Pacchiarotti, I</au><au>Amann, B.L</au><au>A.M.A., Nivoli</au><au>Vieta, E</au><au>Colom, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment adherence in bipolar I and schizoaffective disorder, bipolar type</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>151</volume><issue>3</issue><spage>1003</spage><epage>1008</epage><pages>1003-1008</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><coden>JADID7</coden><abstract>Abstract Background Poor adherence rates in Bipolar Disorder type I (BDI) and Schizoaffective Disorder, bipolar type (SAD) may be high This study was aimed at comparing the clinical correlates of adherence to treatment and the course of illness in BDI and SAD patients. Methods 75 SAD and 150 BDI DSM-IV outpatients were included. Adherence was assessed on the basis of patients’ and care-givers’ reports and serum levels, when available. Socio-demographic, clinical and treatment variables were collected and compared between diagnostic subsamples and then between goodly and poorly adherent patients. Multiple logistic regressions were performed, controlling for diagnostic subsample differences, to identify correlates of adherence in BDI and SAD groups. Results Poor adherence was highly prevalent both in BDI (32%) and in SAD patients (44%), with no significant differences between diagnostic categories. Presence of psychotic symptoms ( p =0.029), higher number of manic relapses ( p <0.001), comorbidity with personality disorders ( p =0.002), and lithium therapy ( p =0.003) were associated with poor adherence to treatment. Diagnostic subgroup analyses showed different predictive models, with the BDI poorly adherent subsample being more likely to include comorbid personality and manic recurrences and the SAD poorly adherent subsample being less clinically predictable. Limitations The cross-sectional nature of the study limits de capacity to ascertain the direction of the relationship between certain variables. Conclusions Rates of poor adherence to oral treatments are similar in SAD and BDI. BDI patients with comorbid personality and substance use disorders are likely to be poorly adherent. Treatment adherence may be more difficult to predict in SAD patients.</abstract><cop>Oxford</cop><pub>Elsevier B.V</pub><pmid>24099884</pmid><doi>10.1016/j.jad.2013.08.026</doi><tpages>6</tpages></addata></record> |
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| subjects | Adherence Adherence to treatment Adherents Adult Adult and adolescent clinical studies Antipsychotic Agents - therapeutic use Biological and medical sciences Bipolar affective disorder Bipolar disorder Bipolar Disorder - drug therapy Bipolar Disorder - psychology Bipolar disorders Comorbidity Cross-Sectional Studies Female Humans Male Medical sciences Medication Adherence - psychology Medication Adherence - statistics & numerical data Miscellaneous Mood disorders Personality Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Psychotic Disorders - drug therapy Psychotic Disorders - psychology Schizoaffective disorder Schizophrenia |
| title | Treatment adherence in bipolar I and schizoaffective disorder, bipolar type |
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