Quality-of-Life–Adjusted Hazard of Death: A Formulation of the Quality-Adjusted Life-Years Model of Use in Benefit-Risk Assessment

Abstract Background Although the quality-adjusted life-years (QALY) model is standard in health technology assessment, quantitative methods are less frequent but increasingly used for benefit-risk assessment (BRA) at earlier stages of drug development. A frequent challenge when implementing metrics...

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Veröffentlicht in:	Value in health 2014-03, Vol.17 (2), p.275-279
1. Verfasser:	Garcia-Hernandez, Alberto, MSc
Format:	Artikel
Sprache:	eng
Schlagworte:	benefit-risk assessment Bias Biological and medical sciences Cost-Benefit Analysis Death Drug Design Drug-Related Side Effects and Adverse Reactions - epidemiology Drug-Related Side Effects and Adverse Reactions - mortality General aspects hazard function Hazards Health Humans Internal Medicine Linear Models mean residual life Medical sciences Miscellaneous Models, Statistical Mortality rate Planification. Prevention (methods). Intervention. Evaluation Probability Proportional Hazards Models Public health. Hygiene Public health. Hygiene-occupational medicine Quality adjusted life years Quality of Life Risk assessment Risk Assessment - methods Time Factors tolerated risk
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