The relationship between Axis I psychopathology and quality of life in adults with mild to moderate intellectual disability

•Examined the relationship between Axis I diagnoses and quality of life in ID.•Compared two Axis I diagnostic groups with a no Axis I diagnosis group on the QOL-Q.•Those with psychotic or Mood/Anxiety Disorders had more impaired quality of life.•No significant differences found between the diagnostic groups.•Those with two or more Axis I diagnoses had more impaired quality of life. Individuals with intellectual disability are at risk for impaired quality of life (QOL) compared to the general population. Little is known, however, about factors that may affect QOL in those with intellectual disability. The current study examined the role that Axis I psychopathology plays in the QOL of 138 adults with moderate to borderline intellectual disability. Scores on the Quality of Life Questionnaire (QOL-Q) were compared between those with a Psychotic Disorder, those with a Mood/Anxiety Disorder, and those with no Axis I diagnosis. Additionally, the effects of number of Axis I diagnoses was explored. Those with no Axis I diagnosis were found to have significantly higher QOL-Q scores than those in either diagnostic group. No significant differences were found between the two diagnostic groups. Additionally, those with no Axis I diagnosis were found to have significantly higher QOL-Q scores than those presenting with two or more Axis I diagnoses. The results and their implications are discussed.