Oxidative stress and lowered total antioxidant status are associated with a history of suicide attempts
Abstract Background There is evidence that depression is accompanied by inflammation, oxidative and nitrosative stress (O&NS) and metabolic disorders. However links between oxidative stress and suicide attempts in depressed patients are poorly understood. This study examines whether a history of...
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| Veröffentlicht in: | Journal of affective disorders 2013-09, Vol.150 (3), p.923-930 |
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| creator | Odebrecht Vargas, Heber Vargas Nunes, Sandra Odebrecht Pizzo de Castro, Marcia Cristina Bortolasci, Chiara Sabbatini Barbosa, Décio Kaminami Morimoto, Helena Venugopal, Kamalesh Dodd, Seetal Maes, Michael Berk, Michael |
| description | Abstract Background There is evidence that depression is accompanied by inflammation, oxidative and nitrosative stress (O&NS) and metabolic disorders. However links between oxidative stress and suicide attempts in depressed patients are poorly understood. This study examines whether a history of suicide attempts is associated with inflammation, O&NS and metabolic disorders. Methods Blood specimens were collected from study participants aged 18–60 ( N =342) recruited at the State University of Londrina, Brazil, and measured for oxidative stress biomarkers: nitric oxide metabolites (NO x ), lipid hydroperoxides, malondialdehyde, advanced oxidation protein products and plasma total antioxidant potential (TRAP); inflammatory biomarkers: fibrinogen, high-sensitivity C-reactive protein, erythrocyte sedimentation rate, interleukin-6 and tumor necrosis factor-α; and metabolic variables. Subjects were divided into those with ( n =141) and without ( n =201) a history of suicidal attempts. Results Individuals with a history of suicide attempts had significantly higher levels of NO x and lipid hydroperoxides and lowered TRAP as compared to individuals without suicide attempts. There were no significant associations between a history of suicide attempts and inflammatory and metabolic biomarkers and metabolic syndrome. Logistic regression showed that both unipolar and bipolar disorder, female gender, smoking behavior and lipid hydroperoxides were significantly associated with a history of suicide attempts. The combined effects of oxidative stress, smoking, depression, female gender were independent from classical risk factors, including marital status, years of education and anxiety. Conclusions O&NS as well as lowered antioxidant levels may play a role in the pathophysiology of suicidal behavior independently from the effects of depression and smoking, both of which are associated with increased O&NS, and classical suicide predictors, such as years of education and marital status. |
| doi_str_mv | 10.1016/j.jad.2013.05.016 |
| format | Article |
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However links between oxidative stress and suicide attempts in depressed patients are poorly understood. This study examines whether a history of suicide attempts is associated with inflammation, O&NS and metabolic disorders. Methods Blood specimens were collected from study participants aged 18–60 ( N =342) recruited at the State University of Londrina, Brazil, and measured for oxidative stress biomarkers: nitric oxide metabolites (NO x ), lipid hydroperoxides, malondialdehyde, advanced oxidation protein products and plasma total antioxidant potential (TRAP); inflammatory biomarkers: fibrinogen, high-sensitivity C-reactive protein, erythrocyte sedimentation rate, interleukin-6 and tumor necrosis factor-α; and metabolic variables. Subjects were divided into those with ( n =141) and without ( n =201) a history of suicidal attempts. Results Individuals with a history of suicide attempts had significantly higher levels of NO x and lipid hydroperoxides and lowered TRAP as compared to individuals without suicide attempts. There were no significant associations between a history of suicide attempts and inflammatory and metabolic biomarkers and metabolic syndrome. Logistic regression showed that both unipolar and bipolar disorder, female gender, smoking behavior and lipid hydroperoxides were significantly associated with a history of suicide attempts. The combined effects of oxidative stress, smoking, depression, female gender were independent from classical risk factors, including marital status, years of education and anxiety. Conclusions O&NS as well as lowered antioxidant levels may play a role in the pathophysiology of suicidal behavior independently from the effects of depression and smoking, both of which are associated with increased O&NS, and classical suicide predictors, such as years of education and marital status.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/j.jad.2013.05.016</identifier><identifier>PMID: 23856278</identifier><identifier>CODEN: JADID7</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Addictive behaviors ; Adolescent ; Adult ; Adult and adolescent clinical studies ; Affective disorders ; Antioxidants ; Anxiety-Depression ; Biological and medical sciences ; Biomarkers - blood ; Brazil - epidemiology ; C-Reactive Protein - analysis ; Depression ; Depression - blood ; Depressive disorders ; Female ; Humans ; Inflammation ; Inflammation - blood ; Interleukin-6 - blood ; Lipids ; Logistic Models ; Male ; Medical sciences ; Metabolic Syndrome - blood ; Metabolism ; Middle Aged ; Mood disorders ; Nicotine dependence ; Nitric Acid - blood ; Oxidative Stress ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Risk Factors ; Self Report ; Smoking ; Smoking - blood ; Suicidal behaviour ; Suicide ; Suicide, Attempted ; Tobacco smoking ; Tobacco, tobacco smoking ; Toxicology ; Tumor Necrosis Factor-alpha - blood ; Young Adult</subject><ispartof>Journal of affective disorders, 2013-09, Vol.150 (3), p.923-930</ispartof><rights>2013</rights><rights>2015 INIST-CNRS</rights><rights>2013 Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-cea170721b6e660b4d2e1a8b317cff1d901894e220b2d33c9be7769020b6b07e3</citedby><cites>FETCH-LOGICAL-c537t-cea170721b6e660b4d2e1a8b317cff1d901894e220b2d33c9be7769020b6b07e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jad.2013.05.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,31000,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27720773$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23856278$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Odebrecht Vargas, Heber</creatorcontrib><creatorcontrib>Vargas Nunes, Sandra Odebrecht</creatorcontrib><creatorcontrib>Pizzo de Castro, Marcia</creatorcontrib><creatorcontrib>Cristina Bortolasci, Chiara</creatorcontrib><creatorcontrib>Sabbatini Barbosa, Décio</creatorcontrib><creatorcontrib>Kaminami Morimoto, Helena</creatorcontrib><creatorcontrib>Venugopal, Kamalesh</creatorcontrib><creatorcontrib>Dodd, Seetal</creatorcontrib><creatorcontrib>Maes, Michael</creatorcontrib><creatorcontrib>Berk, Michael</creatorcontrib><title>Oxidative stress and lowered total antioxidant status are associated with a history of suicide attempts</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>Abstract Background There is evidence that depression is accompanied by inflammation, oxidative and nitrosative stress (O&NS) and metabolic disorders. However links between oxidative stress and suicide attempts in depressed patients are poorly understood. This study examines whether a history of suicide attempts is associated with inflammation, O&NS and metabolic disorders. Methods Blood specimens were collected from study participants aged 18–60 ( N =342) recruited at the State University of Londrina, Brazil, and measured for oxidative stress biomarkers: nitric oxide metabolites (NO x ), lipid hydroperoxides, malondialdehyde, advanced oxidation protein products and plasma total antioxidant potential (TRAP); inflammatory biomarkers: fibrinogen, high-sensitivity C-reactive protein, erythrocyte sedimentation rate, interleukin-6 and tumor necrosis factor-α; and metabolic variables. Subjects were divided into those with ( n =141) and without ( n =201) a history of suicidal attempts. Results Individuals with a history of suicide attempts had significantly higher levels of NO x and lipid hydroperoxides and lowered TRAP as compared to individuals without suicide attempts. There were no significant associations between a history of suicide attempts and inflammatory and metabolic biomarkers and metabolic syndrome. Logistic regression showed that both unipolar and bipolar disorder, female gender, smoking behavior and lipid hydroperoxides were significantly associated with a history of suicide attempts. The combined effects of oxidative stress, smoking, depression, female gender were independent from classical risk factors, including marital status, years of education and anxiety. Conclusions O&NS as well as lowered antioxidant levels may play a role in the pathophysiology of suicidal behavior independently from the effects of depression and smoking, both of which are associated with increased O&NS, and classical suicide predictors, such as years of education and marital status.</description><subject>Addictive behaviors</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Affective disorders</subject><subject>Antioxidants</subject><subject>Anxiety-Depression</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Brazil - epidemiology</subject><subject>C-Reactive Protein - analysis</subject><subject>Depression</subject><subject>Depression - blood</subject><subject>Depressive disorders</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - blood</subject><subject>Interleukin-6 - blood</subject><subject>Lipids</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Nicotine dependence</subject><subject>Nitric Acid - blood</subject><subject>Oxidative Stress</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Risk Factors</subject><subject>Self Report</subject><subject>Smoking</subject><subject>Smoking - blood</subject><subject>Suicidal behaviour</subject><subject>Suicide</subject><subject>Suicide, Attempted</subject><subject>Tobacco smoking</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Young Adult</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqN0lGL1DAQB_Aiird3-gF8kb4IvmydJG3SIgjHoadwcA_qc0iTqZfabdZMeud-e7PsquCD7FPI8JtJ4D9F8YJBxYDJN2M1GldxYKKCpsqVR8WKNUqsecPU42KVK80aBFdnxTnRCACyU_C0OOOibSRX7ar4dvvTO5P8PZaUIhKVZnblFB4woitTSGbKleTDns0pI5OWjCKWhihYb1J2Dz7dlaa885RC3JVhKGnx1ruMUsLNNtGz4slgJsLnx_Oi-Prh_Zerj-ub2-tPV5c3a9sIldYWDVOgOOslSgl97Tgy0_aCKTsMzHXA2q5GzqHnTgjb9aiU7CDfZQ8KxUXx-jB3G8OPBSnpjSeL02RmDAtp1tSsa0G26gQq6rbmddedQAFUJ-EUWvNO1g2XdabsQG0MRBEHvY1-Y-JOM9D7gPWoc8B6H7CGRudK7nl5HL_0G3R_On4nmsGrIzBkzTREM1tPf51SHJQS2b09OMxp3HuMmqzH2aLzEW3SLvj_fuPdP9128rPPD37HHdIYljjnmDXTxDXoz_tN3C8iEwBC1Uz8AmOj1ws</recordid><startdate>20130925</startdate><enddate>20130925</enddate><creator>Odebrecht Vargas, Heber</creator><creator>Vargas Nunes, Sandra Odebrecht</creator><creator>Pizzo de Castro, Marcia</creator><creator>Cristina Bortolasci, Chiara</creator><creator>Sabbatini Barbosa, Décio</creator><creator>Kaminami Morimoto, Helena</creator><creator>Venugopal, Kamalesh</creator><creator>Dodd, Seetal</creator><creator>Maes, Michael</creator><creator>Berk, Michael</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>7QJ</scope></search><sort><creationdate>20130925</creationdate><title>Oxidative stress and lowered total antioxidant status are associated with a history of suicide attempts</title><author>Odebrecht Vargas, Heber ; Vargas Nunes, Sandra Odebrecht ; Pizzo de Castro, Marcia ; Cristina Bortolasci, Chiara ; Sabbatini Barbosa, Décio ; Kaminami Morimoto, Helena ; Venugopal, Kamalesh ; Dodd, Seetal ; Maes, Michael ; Berk, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-cea170721b6e660b4d2e1a8b317cff1d901894e220b2d33c9be7769020b6b07e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Addictive behaviors</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Affective disorders</topic><topic>Antioxidants</topic><topic>Anxiety-Depression</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Brazil - epidemiology</topic><topic>C-Reactive Protein - analysis</topic><topic>Depression</topic><topic>Depression - blood</topic><topic>Depressive disorders</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - blood</topic><topic>Interleukin-6 - blood</topic><topic>Lipids</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Nicotine dependence</topic><topic>Nitric Acid - blood</topic><topic>Oxidative Stress</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Risk Factors</topic><topic>Self Report</topic><topic>Smoking</topic><topic>Smoking - blood</topic><topic>Suicidal behaviour</topic><topic>Suicide</topic><topic>Suicide, Attempted</topic><topic>Tobacco smoking</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxicology</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Odebrecht Vargas, Heber</creatorcontrib><creatorcontrib>Vargas Nunes, Sandra Odebrecht</creatorcontrib><creatorcontrib>Pizzo de Castro, Marcia</creatorcontrib><creatorcontrib>Cristina Bortolasci, Chiara</creatorcontrib><creatorcontrib>Sabbatini Barbosa, Décio</creatorcontrib><creatorcontrib>Kaminami Morimoto, Helena</creatorcontrib><creatorcontrib>Venugopal, Kamalesh</creatorcontrib><creatorcontrib>Dodd, Seetal</creatorcontrib><creatorcontrib>Maes, Michael</creatorcontrib><creatorcontrib>Berk, Michael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Odebrecht Vargas, Heber</au><au>Vargas Nunes, Sandra Odebrecht</au><au>Pizzo de Castro, Marcia</au><au>Cristina Bortolasci, Chiara</au><au>Sabbatini Barbosa, Décio</au><au>Kaminami Morimoto, Helena</au><au>Venugopal, Kamalesh</au><au>Dodd, Seetal</au><au>Maes, Michael</au><au>Berk, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidative stress and lowered total antioxidant status are associated with a history of suicide attempts</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>2013-09-25</date><risdate>2013</risdate><volume>150</volume><issue>3</issue><spage>923</spage><epage>930</epage><pages>923-930</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><coden>JADID7</coden><abstract>Abstract Background There is evidence that depression is accompanied by inflammation, oxidative and nitrosative stress (O&NS) and metabolic disorders. However links between oxidative stress and suicide attempts in depressed patients are poorly understood. This study examines whether a history of suicide attempts is associated with inflammation, O&NS and metabolic disorders. Methods Blood specimens were collected from study participants aged 18–60 ( N =342) recruited at the State University of Londrina, Brazil, and measured for oxidative stress biomarkers: nitric oxide metabolites (NO x ), lipid hydroperoxides, malondialdehyde, advanced oxidation protein products and plasma total antioxidant potential (TRAP); inflammatory biomarkers: fibrinogen, high-sensitivity C-reactive protein, erythrocyte sedimentation rate, interleukin-6 and tumor necrosis factor-α; and metabolic variables. Subjects were divided into those with ( n =141) and without ( n =201) a history of suicidal attempts. Results Individuals with a history of suicide attempts had significantly higher levels of NO x and lipid hydroperoxides and lowered TRAP as compared to individuals without suicide attempts. There were no significant associations between a history of suicide attempts and inflammatory and metabolic biomarkers and metabolic syndrome. Logistic regression showed that both unipolar and bipolar disorder, female gender, smoking behavior and lipid hydroperoxides were significantly associated with a history of suicide attempts. The combined effects of oxidative stress, smoking, depression, female gender were independent from classical risk factors, including marital status, years of education and anxiety. Conclusions O&NS as well as lowered antioxidant levels may play a role in the pathophysiology of suicidal behavior independently from the effects of depression and smoking, both of which are associated with increased O&NS, and classical suicide predictors, such as years of education and marital status.</abstract><cop>Oxford</cop><pub>Elsevier B.V</pub><pmid>23856278</pmid><doi>10.1016/j.jad.2013.05.016</doi><tpages>8</tpages></addata></record> |
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| subjects | Addictive behaviors Adolescent Adult Adult and adolescent clinical studies Affective disorders Antioxidants Anxiety-Depression Biological and medical sciences Biomarkers - blood Brazil - epidemiology C-Reactive Protein - analysis Depression Depression - blood Depressive disorders Female Humans Inflammation Inflammation - blood Interleukin-6 - blood Lipids Logistic Models Male Medical sciences Metabolic Syndrome - blood Metabolism Middle Aged Mood disorders Nicotine dependence Nitric Acid - blood Oxidative Stress Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Risk Factors Self Report Smoking Smoking - blood Suicidal behaviour Suicide Suicide, Attempted Tobacco smoking Tobacco, tobacco smoking Toxicology Tumor Necrosis Factor-alpha - blood Young Adult |
| title | Oxidative stress and lowered total antioxidant status are associated with a history of suicide attempts |
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