Genetic variants of the BDNF and DRD3 genes in bipolar disorder comorbid with anxiety disorder
Abstract Background The high comorbidity rate between bipolar disorder (BP) and anxiety disorder (AD) has been studied in depth. This comorbidity is not as high in Han Chinese in Taiwan. Therefore, we explored the genetic effects BP comorbid with AD. Methods We recruited 1316 participants: 286 with...
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| creator | Chang, Yun-Hsuan Lee, Sheng-Yu Chen, Shiou-Lan Tzeng, Nian-Sheng Wang, Tzu-Yun Hui Lee, I See Chen, Po Huang, San-Yuan Kuang Yang, Yen Ko, Hui-Chen Lu, Ru-Band |
| description | Abstract Background The high comorbidity rate between bipolar disorder (BP) and anxiety disorder (AD) has been studied in depth. This comorbidity is not as high in Han Chinese in Taiwan. Therefore, we explored the genetic effects BP comorbid with AD. Methods We recruited 1316 participants: 286 with BP-I, 681 with BP-II, and 349 healthy Controls. Genotypes of the BDNF Val66Met and DRD3 Ser9Gly polymorphisms were determined using polymerase chain reactions plus restriction fragment length polymorphism analysis. Results The DRD3 Ser9Gly polymorphism was associated with BP-II comorbid with AD (BPII+AD ), and the BDNF Val66Met polymorphism was associated with BP-I comorbid with AD (BPI+AD ). An interaction between the Val/Val genotype of the BDNF Val66Met and Gly/Gly polymorphism of the DRD3 Ser9Gly was found in BPII+AD , but not in BP-II not comorbid with AD (BPI−AD ) compared with healthy Controls. Limitation The low comorbidity rate of AD in both BP subtypes, especially BP-I, limit generalizing our findings. Conclusion The involvement of the dopaminergic pathway in AD was confirmed, particularly with BP-II rather than BP-I. Because the Val/Val genotype of the BDNF Val66Met polymorphism, rather than the other two polymorphisms, has been associated with anxiety, it seems to affect BP-I comorbid with AD without the involvement of the DRD3 Seg9Gly polymorphism, but may modify the involvement of DRD3 Gly/Gly in BP-II comorbid with AD. |
| doi_str_mv | 10.1016/j.jad.2013.08.017 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1541979821</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0165032713006393</els_id><sourcerecordid>1516748065</sourcerecordid><originalsourceid>FETCH-LOGICAL-c537t-3f7a001e1c62ae088d89659216d836f7698752d477b58f041259e3f9aa68677c3</originalsourceid><addsrcrecordid>eNqNks1rFDEchgdR7Fr9A7xILoKXGfMx-UIQatdWoSj4cTVkk9_YjLOTNZltu_-9GXat4EF7yiHP-ybwvFX1lOCGYCJe9k1vfUMxYQ1WDSbyXrUgXLKaciLvV4vC8BozKo-qRzn3GGOhJX5YHdEWU6IFXlTfzmGEKTh0ZVOw45RR7NB0CejN8sMZsqNHy09Lhr4XKqMwolXYxMEm5EOOyUNCLq5jWgWPrsN0WQI3Aabd7fXj6kFnhwxPDudx9fXs7ZfTd_XFx_P3pycXteNMTjXrpMWYAHGCWsBKeaUF15QIr5jopNBKcupbKVdcdbgllGtgnbZWKCGlY8fVi33vJsWfW8iTWYfsYBjsCHGbDeEt0VIrSu6AslYxJrm4A0qEbBUW_P9o2wolqea6oGSPuhRzTtCZTQprm3aGYDN7Nb0pXs3s1WBliteSeXao367W4G8Tv0UW4PkBsNnZoUt2dCH_4aRmVPC56NWeg2LjKkAy2QUYHfiQwE3Gx_DPb7z-K-2GMIby4A_YQe7jNo1FsyEmU4PN53mA8_4IK9NjmrFfD0zQtg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1446872959</pqid></control><display><type>article</type><title>Genetic variants of the BDNF and DRD3 genes in bipolar disorder comorbid with anxiety disorder</title><source>MEDLINE</source><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>Access via ScienceDirect (Elsevier)</source><creator>Chang, Yun-Hsuan ; Lee, Sheng-Yu ; Chen, Shiou-Lan ; Tzeng, Nian-Sheng ; Wang, Tzu-Yun ; Hui Lee, I ; See Chen, Po ; Huang, San-Yuan ; Kuang Yang, Yen ; Ko, Hui-Chen ; Lu, Ru-Band</creator><creatorcontrib>Chang, Yun-Hsuan ; Lee, Sheng-Yu ; Chen, Shiou-Lan ; Tzeng, Nian-Sheng ; Wang, Tzu-Yun ; Hui Lee, I ; See Chen, Po ; Huang, San-Yuan ; Kuang Yang, Yen ; Ko, Hui-Chen ; Lu, Ru-Band</creatorcontrib><description>Abstract Background The high comorbidity rate between bipolar disorder (BP) and anxiety disorder (AD) has been studied in depth. This comorbidity is not as high in Han Chinese in Taiwan. Therefore, we explored the genetic effects BP comorbid with AD. Methods We recruited 1316 participants: 286 with BP-I, 681 with BP-II, and 349 healthy Controls. Genotypes of the BDNF Val66Met and DRD3 Ser9Gly polymorphisms were determined using polymerase chain reactions plus restriction fragment length polymorphism analysis. Results The DRD3 Ser9Gly polymorphism was associated with BP-II comorbid with AD (BPII+AD ), and the BDNF Val66Met polymorphism was associated with BP-I comorbid with AD (BPI+AD ). An interaction between the Val/Val genotype of the BDNF Val66Met and Gly/Gly polymorphism of the DRD3 Ser9Gly was found in BPII+AD , but not in BP-II not comorbid with AD (BPI−AD ) compared with healthy Controls. Limitation The low comorbidity rate of AD in both BP subtypes, especially BP-I, limit generalizing our findings. Conclusion The involvement of the dopaminergic pathway in AD was confirmed, particularly with BP-II rather than BP-I. Because the Val/Val genotype of the BDNF Val66Met polymorphism, rather than the other two polymorphisms, has been associated with anxiety, it seems to affect BP-I comorbid with AD without the involvement of the DRD3 Seg9Gly polymorphism, but may modify the involvement of DRD3 Gly/Gly in BP-II comorbid with AD.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/j.jad.2013.08.017</identifier><identifier>PMID: 24021960</identifier><identifier>CODEN: JADID7</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Adult ; Adult and adolescent clinical studies ; Anxiety comorbidity ; Anxiety disorders ; Anxiety Disorders - epidemiology ; Anxiety Disorders - genetics ; Asian Continental Ancestry Group - genetics ; BDNF ; Biological and medical sciences ; Bipolar affective disorder ; Bipolar Disorder - epidemiology ; Bipolar Disorder - genetics ; Bipolar disorders ; Bipolar subtypes ; Brain-Derived Neurotrophic Factor - genetics ; Case-Control Studies ; Comorbidity ; DRD3 ; Female ; Genes ; Genetic Predisposition to Disease ; Gene–gene interaction ; Genotype ; Humans ; Male ; Medical sciences ; Miscellaneous ; Mood disorders ; Polymorphism, Single Nucleotide - genetics ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Receptors, Dopamine D3 - genetics ; Subtypes ; Taiwan - epidemiology ; Variants</subject><ispartof>Journal of affective disorders, 2013-12, Vol.151 (3), p.967-972</ispartof><rights>Elsevier B.V.</rights><rights>2013 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-3f7a001e1c62ae088d89659216d836f7698752d477b58f041259e3f9aa68677c3</citedby><cites>FETCH-LOGICAL-c537t-3f7a001e1c62ae088d89659216d836f7698752d477b58f041259e3f9aa68677c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jad.2013.08.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,31007,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27932657$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24021960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Yun-Hsuan</creatorcontrib><creatorcontrib>Lee, Sheng-Yu</creatorcontrib><creatorcontrib>Chen, Shiou-Lan</creatorcontrib><creatorcontrib>Tzeng, Nian-Sheng</creatorcontrib><creatorcontrib>Wang, Tzu-Yun</creatorcontrib><creatorcontrib>Hui Lee, I</creatorcontrib><creatorcontrib>See Chen, Po</creatorcontrib><creatorcontrib>Huang, San-Yuan</creatorcontrib><creatorcontrib>Kuang Yang, Yen</creatorcontrib><creatorcontrib>Ko, Hui-Chen</creatorcontrib><creatorcontrib>Lu, Ru-Band</creatorcontrib><title>Genetic variants of the BDNF and DRD3 genes in bipolar disorder comorbid with anxiety disorder</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>Abstract Background The high comorbidity rate between bipolar disorder (BP) and anxiety disorder (AD) has been studied in depth. This comorbidity is not as high in Han Chinese in Taiwan. Therefore, we explored the genetic effects BP comorbid with AD. Methods We recruited 1316 participants: 286 with BP-I, 681 with BP-II, and 349 healthy Controls. Genotypes of the BDNF Val66Met and DRD3 Ser9Gly polymorphisms were determined using polymerase chain reactions plus restriction fragment length polymorphism analysis. Results The DRD3 Ser9Gly polymorphism was associated with BP-II comorbid with AD (BPII+AD ), and the BDNF Val66Met polymorphism was associated with BP-I comorbid with AD (BPI+AD ). An interaction between the Val/Val genotype of the BDNF Val66Met and Gly/Gly polymorphism of the DRD3 Ser9Gly was found in BPII+AD , but not in BP-II not comorbid with AD (BPI−AD ) compared with healthy Controls. Limitation The low comorbidity rate of AD in both BP subtypes, especially BP-I, limit generalizing our findings. Conclusion The involvement of the dopaminergic pathway in AD was confirmed, particularly with BP-II rather than BP-I. Because the Val/Val genotype of the BDNF Val66Met polymorphism, rather than the other two polymorphisms, has been associated with anxiety, it seems to affect BP-I comorbid with AD without the involvement of the DRD3 Seg9Gly polymorphism, but may modify the involvement of DRD3 Gly/Gly in BP-II comorbid with AD.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Anxiety comorbidity</subject><subject>Anxiety disorders</subject><subject>Anxiety Disorders - epidemiology</subject><subject>Anxiety Disorders - genetics</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>BDNF</subject><subject>Biological and medical sciences</subject><subject>Bipolar affective disorder</subject><subject>Bipolar Disorder - epidemiology</subject><subject>Bipolar Disorder - genetics</subject><subject>Bipolar disorders</subject><subject>Bipolar subtypes</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Case-Control Studies</subject><subject>Comorbidity</subject><subject>DRD3</subject><subject>Female</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease</subject><subject>Gene–gene interaction</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Mood disorders</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Receptors, Dopamine D3 - genetics</subject><subject>Subtypes</subject><subject>Taiwan - epidemiology</subject><subject>Variants</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNks1rFDEchgdR7Fr9A7xILoKXGfMx-UIQatdWoSj4cTVkk9_YjLOTNZltu_-9GXat4EF7yiHP-ybwvFX1lOCGYCJe9k1vfUMxYQ1WDSbyXrUgXLKaciLvV4vC8BozKo-qRzn3GGOhJX5YHdEWU6IFXlTfzmGEKTh0ZVOw45RR7NB0CejN8sMZsqNHy09Lhr4XKqMwolXYxMEm5EOOyUNCLq5jWgWPrsN0WQI3Aabd7fXj6kFnhwxPDudx9fXs7ZfTd_XFx_P3pycXteNMTjXrpMWYAHGCWsBKeaUF15QIr5jopNBKcupbKVdcdbgllGtgnbZWKCGlY8fVi33vJsWfW8iTWYfsYBjsCHGbDeEt0VIrSu6AslYxJrm4A0qEbBUW_P9o2wolqea6oGSPuhRzTtCZTQprm3aGYDN7Nb0pXs3s1WBliteSeXao367W4G8Tv0UW4PkBsNnZoUt2dCH_4aRmVPC56NWeg2LjKkAy2QUYHfiQwE3Gx_DPb7z-K-2GMIby4A_YQe7jNo1FsyEmU4PN53mA8_4IK9NjmrFfD0zQtg</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Chang, Yun-Hsuan</creator><creator>Lee, Sheng-Yu</creator><creator>Chen, Shiou-Lan</creator><creator>Tzeng, Nian-Sheng</creator><creator>Wang, Tzu-Yun</creator><creator>Hui Lee, I</creator><creator>See Chen, Po</creator><creator>Huang, San-Yuan</creator><creator>Kuang Yang, Yen</creator><creator>Ko, Hui-Chen</creator><creator>Lu, Ru-Band</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7QJ</scope></search><sort><creationdate>20131201</creationdate><title>Genetic variants of the BDNF and DRD3 genes in bipolar disorder comorbid with anxiety disorder</title><author>Chang, Yun-Hsuan ; Lee, Sheng-Yu ; Chen, Shiou-Lan ; Tzeng, Nian-Sheng ; Wang, Tzu-Yun ; Hui Lee, I ; See Chen, Po ; Huang, San-Yuan ; Kuang Yang, Yen ; Ko, Hui-Chen ; Lu, Ru-Band</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-3f7a001e1c62ae088d89659216d836f7698752d477b58f041259e3f9aa68677c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Anxiety comorbidity</topic><topic>Anxiety disorders</topic><topic>Anxiety Disorders - epidemiology</topic><topic>Anxiety Disorders - genetics</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>BDNF</topic><topic>Biological and medical sciences</topic><topic>Bipolar affective disorder</topic><topic>Bipolar Disorder - epidemiology</topic><topic>Bipolar Disorder - genetics</topic><topic>Bipolar disorders</topic><topic>Bipolar subtypes</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>Case-Control Studies</topic><topic>Comorbidity</topic><topic>DRD3</topic><topic>Female</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease</topic><topic>Gene–gene interaction</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Mood disorders</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Receptors, Dopamine D3 - genetics</topic><topic>Subtypes</topic><topic>Taiwan - epidemiology</topic><topic>Variants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Yun-Hsuan</creatorcontrib><creatorcontrib>Lee, Sheng-Yu</creatorcontrib><creatorcontrib>Chen, Shiou-Lan</creatorcontrib><creatorcontrib>Tzeng, Nian-Sheng</creatorcontrib><creatorcontrib>Wang, Tzu-Yun</creatorcontrib><creatorcontrib>Hui Lee, I</creatorcontrib><creatorcontrib>See Chen, Po</creatorcontrib><creatorcontrib>Huang, San-Yuan</creatorcontrib><creatorcontrib>Kuang Yang, Yen</creatorcontrib><creatorcontrib>Ko, Hui-Chen</creatorcontrib><creatorcontrib>Lu, Ru-Band</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Yun-Hsuan</au><au>Lee, Sheng-Yu</au><au>Chen, Shiou-Lan</au><au>Tzeng, Nian-Sheng</au><au>Wang, Tzu-Yun</au><au>Hui Lee, I</au><au>See Chen, Po</au><au>Huang, San-Yuan</au><au>Kuang Yang, Yen</au><au>Ko, Hui-Chen</au><au>Lu, Ru-Band</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic variants of the BDNF and DRD3 genes in bipolar disorder comorbid with anxiety disorder</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>151</volume><issue>3</issue><spage>967</spage><epage>972</epage><pages>967-972</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><coden>JADID7</coden><abstract>Abstract Background The high comorbidity rate between bipolar disorder (BP) and anxiety disorder (AD) has been studied in depth. This comorbidity is not as high in Han Chinese in Taiwan. Therefore, we explored the genetic effects BP comorbid with AD. Methods We recruited 1316 participants: 286 with BP-I, 681 with BP-II, and 349 healthy Controls. Genotypes of the BDNF Val66Met and DRD3 Ser9Gly polymorphisms were determined using polymerase chain reactions plus restriction fragment length polymorphism analysis. Results The DRD3 Ser9Gly polymorphism was associated with BP-II comorbid with AD (BPII+AD ), and the BDNF Val66Met polymorphism was associated with BP-I comorbid with AD (BPI+AD ). An interaction between the Val/Val genotype of the BDNF Val66Met and Gly/Gly polymorphism of the DRD3 Ser9Gly was found in BPII+AD , but not in BP-II not comorbid with AD (BPI−AD ) compared with healthy Controls. Limitation The low comorbidity rate of AD in both BP subtypes, especially BP-I, limit generalizing our findings. Conclusion The involvement of the dopaminergic pathway in AD was confirmed, particularly with BP-II rather than BP-I. Because the Val/Val genotype of the BDNF Val66Met polymorphism, rather than the other two polymorphisms, has been associated with anxiety, it seems to affect BP-I comorbid with AD without the involvement of the DRD3 Seg9Gly polymorphism, but may modify the involvement of DRD3 Gly/Gly in BP-II comorbid with AD.</abstract><cop>Oxford</cop><pub>Elsevier B.V</pub><pmid>24021960</pmid><doi>10.1016/j.jad.2013.08.017</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Anxiety comorbidity Anxiety disorders Anxiety Disorders - epidemiology Anxiety Disorders - genetics Asian Continental Ancestry Group - genetics BDNF Biological and medical sciences Bipolar affective disorder Bipolar Disorder - epidemiology Bipolar Disorder - genetics Bipolar disorders Bipolar subtypes Brain-Derived Neurotrophic Factor - genetics Case-Control Studies Comorbidity DRD3 Female Genes Genetic Predisposition to Disease Gene–gene interaction Genotype Humans Male Medical sciences Miscellaneous Mood disorders Polymorphism, Single Nucleotide - genetics Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, Dopamine D3 - genetics Subtypes Taiwan - epidemiology Variants |
| title | Genetic variants of the BDNF and DRD3 genes in bipolar disorder comorbid with anxiety disorder |
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