Frailty in patients affected by atrial fibrillation
Abstract Atrial fibrillation (AF) is the most common arrhythmia among elderly people. However its relationship with the frailty syndrome is not well understood. It has been suggested that AF may be a marker of frailty in elderly, leading to the loss of independence in performing of routine daily act...
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| Veröffentlicht in: | Archives of gerontology and geriatrics 2013-11, Vol.57 (3), p.325-327 |
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| creator | Polidoro, A Stefanelli, F Ciacciarelli, M Pacelli, A Di Sanzo, D Alessandri, C |
| description | Abstract Atrial fibrillation (AF) is the most common arrhythmia among elderly people. However its relationship with the frailty syndrome is not well understood. It has been suggested that AF may be a marker of frailty in elderly, leading to the loss of independence in performing of routine daily activities. The aim of this study is to investigate the association between AF, frailty and cognitive decline in elderly patients. A total of 140 hospitalized patients, mean age 79.2 ± 7.4 years were enrolled in our study. Of these, 70 were affected by parossistic, persistent or permanent AF and 70, matched for age and gender, were concurrently studied as control. Cognitive impairment and frailty state has been evaluated in each patient using the Mini Mental State Examination (MMSE) and a standard score of accumulated deficits for constructing a frailty index. We have observed a higher number of frail patients in the AF group as compared with controls (88.6% vs 67.1%, p = 0.004). The group of patients with frailty syndrome had MMSE score significantly lower than those of the nonfrail group (16.8 ± 9.8 vs 22.2 ± 6.4, p = 0.005). Furthermore, a negative correlation between MMSE score and frailty index (rho = −0.517, p < 0.001) has been shown. Our study points out a statistical association between frailty and AF. Atrial fibrillation could worsen the frailty state, but perspective studies are necessary to confirm an increased mortality in patients affected by AF and frailty. |
| doi_str_mv | 10.1016/j.archger.2013.04.014 |
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However its relationship with the frailty syndrome is not well understood. It has been suggested that AF may be a marker of frailty in elderly, leading to the loss of independence in performing of routine daily activities. The aim of this study is to investigate the association between AF, frailty and cognitive decline in elderly patients. A total of 140 hospitalized patients, mean age 79.2 ± 7.4 years were enrolled in our study. Of these, 70 were affected by parossistic, persistent or permanent AF and 70, matched for age and gender, were concurrently studied as control. Cognitive impairment and frailty state has been evaluated in each patient using the Mini Mental State Examination (MMSE) and a standard score of accumulated deficits for constructing a frailty index. We have observed a higher number of frail patients in the AF group as compared with controls (88.6% vs 67.1%, p = 0.004). The group of patients with frailty syndrome had MMSE score significantly lower than those of the nonfrail group (16.8 ± 9.8 vs 22.2 ± 6.4, p = 0.005). Furthermore, a negative correlation between MMSE score and frailty index (rho = −0.517, p < 0.001) has been shown. Our study points out a statistical association between frailty and AF. Atrial fibrillation could worsen the frailty state, but perspective studies are necessary to confirm an increased mortality in patients affected by AF and frailty.</description><identifier>ISSN: 0167-4943</identifier><identifier>EISSN: 1872-6976</identifier><identifier>DOI: 10.1016/j.archger.2013.04.014</identifier><identifier>PMID: 23706973</identifier><language>eng</language><publisher>Netherlands: Elsevier Ireland Ltd</publisher><subject>Activities of daily living ; Age Factors ; Aged ; Aged, 80 and over ; Atrial fibrillation ; Atrial Fibrillation - complications ; Case-Control Studies ; Cognitive Dysfunction - etiology ; Cognitive impairment ; Elderly people ; Female ; Frail ; Frail Elderly - statistics & numerical data ; Frailty ; Geriatric Assessment ; Humans ; Internal Medicine ; Male ; Middle Aged ; Minimental State Examination ; Neuropsychological Tests ; Sex Factors</subject><ispartof>Archives of gerontology and geriatrics, 2013-11, Vol.57 (3), p.325-327</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2013 Elsevier Ireland Ltd</rights><rights>Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-5d32415a6e1bcc982604430e938ce8d842a033c9033789b43d0f6dc2590591433</citedby><cites>FETCH-LOGICAL-c519t-5d32415a6e1bcc982604430e938ce8d842a033c9033789b43d0f6dc2590591433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0167494313000745$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,30977,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23706973$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Polidoro, A</creatorcontrib><creatorcontrib>Stefanelli, F</creatorcontrib><creatorcontrib>Ciacciarelli, M</creatorcontrib><creatorcontrib>Pacelli, A</creatorcontrib><creatorcontrib>Di Sanzo, D</creatorcontrib><creatorcontrib>Alessandri, C</creatorcontrib><title>Frailty in patients affected by atrial fibrillation</title><title>Archives of gerontology and geriatrics</title><addtitle>Arch Gerontol Geriatr</addtitle><description>Abstract Atrial fibrillation (AF) is the most common arrhythmia among elderly people. However its relationship with the frailty syndrome is not well understood. It has been suggested that AF may be a marker of frailty in elderly, leading to the loss of independence in performing of routine daily activities. The aim of this study is to investigate the association between AF, frailty and cognitive decline in elderly patients. A total of 140 hospitalized patients, mean age 79.2 ± 7.4 years were enrolled in our study. Of these, 70 were affected by parossistic, persistent or permanent AF and 70, matched for age and gender, were concurrently studied as control. Cognitive impairment and frailty state has been evaluated in each patient using the Mini Mental State Examination (MMSE) and a standard score of accumulated deficits for constructing a frailty index. We have observed a higher number of frail patients in the AF group as compared with controls (88.6% vs 67.1%, p = 0.004). The group of patients with frailty syndrome had MMSE score significantly lower than those of the nonfrail group (16.8 ± 9.8 vs 22.2 ± 6.4, p = 0.005). Furthermore, a negative correlation between MMSE score and frailty index (rho = −0.517, p < 0.001) has been shown. Our study points out a statistical association between frailty and AF. Atrial fibrillation could worsen the frailty state, but perspective studies are necessary to confirm an increased mortality in patients affected by AF and frailty.</description><subject>Activities of daily living</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Atrial fibrillation</subject><subject>Atrial Fibrillation - complications</subject><subject>Case-Control Studies</subject><subject>Cognitive Dysfunction - etiology</subject><subject>Cognitive impairment</subject><subject>Elderly people</subject><subject>Female</subject><subject>Frail</subject><subject>Frail Elderly - statistics & numerical data</subject><subject>Frailty</subject><subject>Geriatric Assessment</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Minimental State Examination</subject><subject>Neuropsychological Tests</subject><subject>Sex Factors</subject><issn>0167-4943</issn><issn>1872-6976</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqFkT1PwzAQhi0EoqXwE0AZWRLOX0m8gFBFAakSAzBbjnMBlzQpdorUf4-rFgYWFt_yvHfW8xJyTiGjQPOrRWa8fX9DnzGgPAORARUHZEzLgqW5KvJDMo5ckQol-IichLAAAAEsPyYjxguIDB8TPvPGtcMmcV2yMoPDbgiJaRq0A9ZJtUnM4J1pk8ZV3rVtJPrulBw1pg14tp8T8jq7e5k-pPOn-8fp7Ty1kqohlTVngkqTI62sVSXLQQgOqHhpsaxLwQxwblV8ilJVgtfQ5LVlUoFUVHA-IZe7vSvff64xDHrpgsX4iw77ddBUCqoKJcv8f1SwAoAqoSIqd6j1fQgeG73ybmn8RlPQW7V6ofdq9VatBqGj2pi72J9YV0usf1M_LiNwswMwOvlyMR5s9Gmxdj7q1HXv_j1x_WeDbV3nrGk_cINh0a99F4VrqgPToJ-3_W7rpTxWWwjJvwG2_p66</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Polidoro, A</creator><creator>Stefanelli, F</creator><creator>Ciacciarelli, M</creator><creator>Pacelli, A</creator><creator>Di Sanzo, D</creator><creator>Alessandri, C</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QJ</scope></search><sort><creationdate>20131101</creationdate><title>Frailty in patients affected by atrial fibrillation</title><author>Polidoro, A ; Stefanelli, F ; Ciacciarelli, M ; Pacelli, A ; Di Sanzo, D ; Alessandri, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-5d32415a6e1bcc982604430e938ce8d842a033c9033789b43d0f6dc2590591433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Activities of daily living</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Atrial fibrillation</topic><topic>Atrial Fibrillation - complications</topic><topic>Case-Control Studies</topic><topic>Cognitive Dysfunction - etiology</topic><topic>Cognitive impairment</topic><topic>Elderly people</topic><topic>Female</topic><topic>Frail</topic><topic>Frail Elderly - statistics & numerical data</topic><topic>Frailty</topic><topic>Geriatric Assessment</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Minimental State Examination</topic><topic>Neuropsychological Tests</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Polidoro, A</creatorcontrib><creatorcontrib>Stefanelli, F</creatorcontrib><creatorcontrib>Ciacciarelli, M</creatorcontrib><creatorcontrib>Pacelli, A</creatorcontrib><creatorcontrib>Di Sanzo, D</creatorcontrib><creatorcontrib>Alessandri, C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>Archives of gerontology and geriatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Polidoro, A</au><au>Stefanelli, F</au><au>Ciacciarelli, M</au><au>Pacelli, A</au><au>Di Sanzo, D</au><au>Alessandri, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frailty in patients affected by atrial fibrillation</atitle><jtitle>Archives of gerontology and geriatrics</jtitle><addtitle>Arch Gerontol Geriatr</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>57</volume><issue>3</issue><spage>325</spage><epage>327</epage><pages>325-327</pages><issn>0167-4943</issn><eissn>1872-6976</eissn><abstract>Abstract Atrial fibrillation (AF) is the most common arrhythmia among elderly people. However its relationship with the frailty syndrome is not well understood. It has been suggested that AF may be a marker of frailty in elderly, leading to the loss of independence in performing of routine daily activities. The aim of this study is to investigate the association between AF, frailty and cognitive decline in elderly patients. A total of 140 hospitalized patients, mean age 79.2 ± 7.4 years were enrolled in our study. Of these, 70 were affected by parossistic, persistent or permanent AF and 70, matched for age and gender, were concurrently studied as control. Cognitive impairment and frailty state has been evaluated in each patient using the Mini Mental State Examination (MMSE) and a standard score of accumulated deficits for constructing a frailty index. We have observed a higher number of frail patients in the AF group as compared with controls (88.6% vs 67.1%, p = 0.004). The group of patients with frailty syndrome had MMSE score significantly lower than those of the nonfrail group (16.8 ± 9.8 vs 22.2 ± 6.4, p = 0.005). Furthermore, a negative correlation between MMSE score and frailty index (rho = −0.517, p < 0.001) has been shown. Our study points out a statistical association between frailty and AF. Atrial fibrillation could worsen the frailty state, but perspective studies are necessary to confirm an increased mortality in patients affected by AF and frailty.</abstract><cop>Netherlands</cop><pub>Elsevier Ireland Ltd</pub><pmid>23706973</pmid><doi>10.1016/j.archger.2013.04.014</doi><tpages>3</tpages></addata></record> |
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| subjects | Activities of daily living Age Factors Aged Aged, 80 and over Atrial fibrillation Atrial Fibrillation - complications Case-Control Studies Cognitive Dysfunction - etiology Cognitive impairment Elderly people Female Frail Frail Elderly - statistics & numerical data Frailty Geriatric Assessment Humans Internal Medicine Male Middle Aged Minimental State Examination Neuropsychological Tests Sex Factors |
| title | Frailty in patients affected by atrial fibrillation |
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