Age-associated reduction of stimulatory effect of ghrelin on food intake in mice
Abstract Aging is associated with a progressive decrease in appetite and food intake. We focused on the age-associated changes of the stimulatory effect of the appetite-regulating peptide, ghrelin. Food intake and the concentrations of acyl ghrelin and desacyl ghrelin in the plasma and in the stomac...
Gespeichert in:
| Veröffentlicht in: | Archives of gerontology and geriatrics 2012-09, Vol.55 (2), p.238-243 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 243 |
|---|---|
| container_issue | 2 |
| container_start_page | 238 |
| container_title | Archives of gerontology and geriatrics |
| container_volume | 55 |
| creator | Akimoto, Yosuke Kanai, Setsuko Ohta, Minoru Akimoto, Saeko Uematsu, Hiroshi Miyasaka, Kyoko |
| description | Abstract Aging is associated with a progressive decrease in appetite and food intake. We focused on the age-associated changes of the stimulatory effect of the appetite-regulating peptide, ghrelin. Food intake and the concentrations of acyl ghrelin and desacyl ghrelin in the plasma and in the stomach were measured with and without overnight fasting in young and old mice. Moreover, the food intake in response to the intraperitoneal administration of graded doses of acyl ghrelin was compared between young and old mice. Fasting drives food intake in young mice, but not in old mice. The concentrations of acyl ghrelin and desacyl ghrelin in the plasma and in the stomach were higher in the old mice than in the young mice. Food intake did not increase in old mice when stimulated by the administration of 1–3 nmol of acyl ghrelin, which could produce a significant increase in food intake in young mice. In conclusion, food intake did not increase in old mice after either overnight fasting or the administration of acyl ghrelin. The release and synthesis of ghrelin seem to be rather higher in old mice compared to young mice. These increases might be the results of compensation for the decline of receptor (and/or post-receptor) functions. |
| doi_str_mv | 10.1016/j.archger.2011.09.007 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1541977141</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S016749431100272X</els_id><sourcerecordid>1033456395</sourcerecordid><originalsourceid>FETCH-LOGICAL-c453t-ddde9852e3fd4647012453b130dcb1f3bdae573b6fd248f1665e5696d6f6f7383</originalsourceid><addsrcrecordid>eNqFkU2LFDEQhoMo7rj6E5Q-euk23-lclGXxCxYUVPAW0kllNrPdnTXpFubfm2ZGD172VFA8bxU8L0IvCe4IJvLNobPZ3e4hdxQT0mHdYaweoR3pFW2lVvIx2lVOtVxzdoGelXLAGHNM5VN0QYkWvSJih75e7aG1pSQX7QK-yeBXt8Q0Nyk0ZYnTOtol5WMDIYBbtu3-NsMYKzA3ISXfxHmxd1BHM0UHz9GTYMcCL87zEv348P779af25svHz9dXN63jgi2t9x50Lyiw4LnkChNa9wNh2LuBBDZ4C0KxQQZPeR-IlAKE1NLLIINiPbtEr09373P6tUJZzBSLg3G0M6S1GCI40UoRTh5GMWNcSKZFRcUJdTmVkiGY-xwnm48VMpt3czBn72bzbrA21XvNvTq_WIcJ_L_UX9EVeHcCoDr5HWu8uAizAx9z9Wp8ig--ePvfBVdbiM6Od3CEckhrnqtwQ0yhBptvW_lb94RgTBX9yf4AEJeqxQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1033456395</pqid></control><display><type>article</type><title>Age-associated reduction of stimulatory effect of ghrelin on food intake in mice</title><source>MEDLINE</source><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>Access via ScienceDirect (Elsevier)</source><creator>Akimoto, Yosuke ; Kanai, Setsuko ; Ohta, Minoru ; Akimoto, Saeko ; Uematsu, Hiroshi ; Miyasaka, Kyoko</creator><creatorcontrib>Akimoto, Yosuke ; Kanai, Setsuko ; Ohta, Minoru ; Akimoto, Saeko ; Uematsu, Hiroshi ; Miyasaka, Kyoko</creatorcontrib><description>Abstract Aging is associated with a progressive decrease in appetite and food intake. We focused on the age-associated changes of the stimulatory effect of the appetite-regulating peptide, ghrelin. Food intake and the concentrations of acyl ghrelin and desacyl ghrelin in the plasma and in the stomach were measured with and without overnight fasting in young and old mice. Moreover, the food intake in response to the intraperitoneal administration of graded doses of acyl ghrelin was compared between young and old mice. Fasting drives food intake in young mice, but not in old mice. The concentrations of acyl ghrelin and desacyl ghrelin in the plasma and in the stomach were higher in the old mice than in the young mice. Food intake did not increase in old mice when stimulated by the administration of 1–3 nmol of acyl ghrelin, which could produce a significant increase in food intake in young mice. In conclusion, food intake did not increase in old mice after either overnight fasting or the administration of acyl ghrelin. The release and synthesis of ghrelin seem to be rather higher in old mice compared to young mice. These increases might be the results of compensation for the decline of receptor (and/or post-receptor) functions.</description><identifier>ISSN: 0167-4943</identifier><identifier>EISSN: 1872-6976</identifier><identifier>DOI: 10.1016/j.archger.2011.09.007</identifier><identifier>PMID: 21958715</identifier><language>eng</language><publisher>Netherlands: Elsevier Ireland Ltd</publisher><subject>Age Factors ; Aging ; Animals ; Appetite - drug effects ; Appetite - physiology ; Eating - drug effects ; Eating - physiology ; Eating behaviour ; Fasting ; Fasting - blood ; Fasting - physiology ; Food ; Food intake ; Ghrelin ; Ghrelin - analysis ; Ghrelin - pharmacology ; Ghrelin - physiology ; Hormones ; Internal Medicine ; Male ; Mice ; Mice, Inbred C57BL ; Stomach ; Stomach - chemistry ; Stomach - physiology</subject><ispartof>Archives of gerontology and geriatrics, 2012-09, Vol.55 (2), p.238-243</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2011 Elsevier Ireland Ltd</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-ddde9852e3fd4647012453b130dcb1f3bdae573b6fd248f1665e5696d6f6f7383</citedby><cites>FETCH-LOGICAL-c453t-ddde9852e3fd4647012453b130dcb1f3bdae573b6fd248f1665e5696d6f6f7383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.archger.2011.09.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,31000,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21958715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akimoto, Yosuke</creatorcontrib><creatorcontrib>Kanai, Setsuko</creatorcontrib><creatorcontrib>Ohta, Minoru</creatorcontrib><creatorcontrib>Akimoto, Saeko</creatorcontrib><creatorcontrib>Uematsu, Hiroshi</creatorcontrib><creatorcontrib>Miyasaka, Kyoko</creatorcontrib><title>Age-associated reduction of stimulatory effect of ghrelin on food intake in mice</title><title>Archives of gerontology and geriatrics</title><addtitle>Arch Gerontol Geriatr</addtitle><description>Abstract Aging is associated with a progressive decrease in appetite and food intake. We focused on the age-associated changes of the stimulatory effect of the appetite-regulating peptide, ghrelin. Food intake and the concentrations of acyl ghrelin and desacyl ghrelin in the plasma and in the stomach were measured with and without overnight fasting in young and old mice. Moreover, the food intake in response to the intraperitoneal administration of graded doses of acyl ghrelin was compared between young and old mice. Fasting drives food intake in young mice, but not in old mice. The concentrations of acyl ghrelin and desacyl ghrelin in the plasma and in the stomach were higher in the old mice than in the young mice. Food intake did not increase in old mice when stimulated by the administration of 1–3 nmol of acyl ghrelin, which could produce a significant increase in food intake in young mice. In conclusion, food intake did not increase in old mice after either overnight fasting or the administration of acyl ghrelin. The release and synthesis of ghrelin seem to be rather higher in old mice compared to young mice. These increases might be the results of compensation for the decline of receptor (and/or post-receptor) functions.</description><subject>Age Factors</subject><subject>Aging</subject><subject>Animals</subject><subject>Appetite - drug effects</subject><subject>Appetite - physiology</subject><subject>Eating - drug effects</subject><subject>Eating - physiology</subject><subject>Eating behaviour</subject><subject>Fasting</subject><subject>Fasting - blood</subject><subject>Fasting - physiology</subject><subject>Food</subject><subject>Food intake</subject><subject>Ghrelin</subject><subject>Ghrelin - analysis</subject><subject>Ghrelin - pharmacology</subject><subject>Ghrelin - physiology</subject><subject>Hormones</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Stomach</subject><subject>Stomach - chemistry</subject><subject>Stomach - physiology</subject><issn>0167-4943</issn><issn>1872-6976</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqFkU2LFDEQhoMo7rj6E5Q-euk23-lclGXxCxYUVPAW0kllNrPdnTXpFubfm2ZGD172VFA8bxU8L0IvCe4IJvLNobPZ3e4hdxQT0mHdYaweoR3pFW2lVvIx2lVOtVxzdoGelXLAGHNM5VN0QYkWvSJih75e7aG1pSQX7QK-yeBXt8Q0Nyk0ZYnTOtol5WMDIYBbtu3-NsMYKzA3ISXfxHmxd1BHM0UHz9GTYMcCL87zEv348P779af25svHz9dXN63jgi2t9x50Lyiw4LnkChNa9wNh2LuBBDZ4C0KxQQZPeR-IlAKE1NLLIINiPbtEr09373P6tUJZzBSLg3G0M6S1GCI40UoRTh5GMWNcSKZFRcUJdTmVkiGY-xwnm48VMpt3czBn72bzbrA21XvNvTq_WIcJ_L_UX9EVeHcCoDr5HWu8uAizAx9z9Wp8ig--ePvfBVdbiM6Od3CEckhrnqtwQ0yhBptvW_lb94RgTBX9yf4AEJeqxQ</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Akimoto, Yosuke</creator><creator>Kanai, Setsuko</creator><creator>Ohta, Minoru</creator><creator>Akimoto, Saeko</creator><creator>Uematsu, Hiroshi</creator><creator>Miyasaka, Kyoko</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QJ</scope></search><sort><creationdate>20120901</creationdate><title>Age-associated reduction of stimulatory effect of ghrelin on food intake in mice</title><author>Akimoto, Yosuke ; Kanai, Setsuko ; Ohta, Minoru ; Akimoto, Saeko ; Uematsu, Hiroshi ; Miyasaka, Kyoko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-ddde9852e3fd4647012453b130dcb1f3bdae573b6fd248f1665e5696d6f6f7383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Age Factors</topic><topic>Aging</topic><topic>Animals</topic><topic>Appetite - drug effects</topic><topic>Appetite - physiology</topic><topic>Eating - drug effects</topic><topic>Eating - physiology</topic><topic>Eating behaviour</topic><topic>Fasting</topic><topic>Fasting - blood</topic><topic>Fasting - physiology</topic><topic>Food</topic><topic>Food intake</topic><topic>Ghrelin</topic><topic>Ghrelin - analysis</topic><topic>Ghrelin - pharmacology</topic><topic>Ghrelin - physiology</topic><topic>Hormones</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Stomach</topic><topic>Stomach - chemistry</topic><topic>Stomach - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akimoto, Yosuke</creatorcontrib><creatorcontrib>Kanai, Setsuko</creatorcontrib><creatorcontrib>Ohta, Minoru</creatorcontrib><creatorcontrib>Akimoto, Saeko</creatorcontrib><creatorcontrib>Uematsu, Hiroshi</creatorcontrib><creatorcontrib>Miyasaka, Kyoko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>Archives of gerontology and geriatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akimoto, Yosuke</au><au>Kanai, Setsuko</au><au>Ohta, Minoru</au><au>Akimoto, Saeko</au><au>Uematsu, Hiroshi</au><au>Miyasaka, Kyoko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-associated reduction of stimulatory effect of ghrelin on food intake in mice</atitle><jtitle>Archives of gerontology and geriatrics</jtitle><addtitle>Arch Gerontol Geriatr</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>55</volume><issue>2</issue><spage>238</spage><epage>243</epage><pages>238-243</pages><issn>0167-4943</issn><eissn>1872-6976</eissn><abstract>Abstract Aging is associated with a progressive decrease in appetite and food intake. We focused on the age-associated changes of the stimulatory effect of the appetite-regulating peptide, ghrelin. Food intake and the concentrations of acyl ghrelin and desacyl ghrelin in the plasma and in the stomach were measured with and without overnight fasting in young and old mice. Moreover, the food intake in response to the intraperitoneal administration of graded doses of acyl ghrelin was compared between young and old mice. Fasting drives food intake in young mice, but not in old mice. The concentrations of acyl ghrelin and desacyl ghrelin in the plasma and in the stomach were higher in the old mice than in the young mice. Food intake did not increase in old mice when stimulated by the administration of 1–3 nmol of acyl ghrelin, which could produce a significant increase in food intake in young mice. In conclusion, food intake did not increase in old mice after either overnight fasting or the administration of acyl ghrelin. The release and synthesis of ghrelin seem to be rather higher in old mice compared to young mice. These increases might be the results of compensation for the decline of receptor (and/or post-receptor) functions.</abstract><cop>Netherlands</cop><pub>Elsevier Ireland Ltd</pub><pmid>21958715</pmid><doi>10.1016/j.archger.2011.09.007</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0167-4943 |
| ispartof | Archives of gerontology and geriatrics, 2012-09, Vol.55 (2), p.238-243 |
| issn | 0167-4943 1872-6976 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1541977141 |
| source | MEDLINE; Applied Social Sciences Index & Abstracts (ASSIA); Access via ScienceDirect (Elsevier) |
| subjects | Age Factors Aging Animals Appetite - drug effects Appetite - physiology Eating - drug effects Eating - physiology Eating behaviour Fasting Fasting - blood Fasting - physiology Food Food intake Ghrelin Ghrelin - analysis Ghrelin - pharmacology Ghrelin - physiology Hormones Internal Medicine Male Mice Mice, Inbred C57BL Stomach Stomach - chemistry Stomach - physiology |
| title | Age-associated reduction of stimulatory effect of ghrelin on food intake in mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T12%3A12%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Age-associated%20reduction%20of%20stimulatory%20effect%20of%20ghrelin%20on%20food%20intake%20in%20mice&rft.jtitle=Archives%20of%20gerontology%20and%20geriatrics&rft.au=Akimoto,%20Yosuke&rft.date=2012-09-01&rft.volume=55&rft.issue=2&rft.spage=238&rft.epage=243&rft.pages=238-243&rft.issn=0167-4943&rft.eissn=1872-6976&rft_id=info:doi/10.1016/j.archger.2011.09.007&rft_dat=%3Cproquest_cross%3E1033456395%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1033456395&rft_id=info:pmid/21958715&rft_els_id=1_s2_0_S016749431100272X&rfr_iscdi=true |