Release and metabolism of dopamine in a clonal line of pheochromocytoma (PC12) cells exposed to fenthion

The effects of an organophosphate (OP) pesticide, fenthion (FEN), on the release and metabolism of dopamine were evaluated in a clonal line of rat pheochromocytoma (PC12) cells. HPLC was used to determine media concentrations of DA and the DA metabolites norepinephrine (NE), 3,4-dihydroxyphenylaceti...

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Veröffentlicht in:	Fundamental and applied toxicology 1989-10, Vol.13 (3), p.484-492
Hauptverfasser:	Tuler, Sheila M., Hazen, Allison A., Bowen, John M.
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - metabolism Adrenal Gland Neoplasms - metabolism Animals Biological and medical sciences CELL CULTURE CLONE CLONES CULTIVO DE CELULAS CULTURE DE CELLULES DOPAMINA DOPAMINE Dopamine - analogs & derivatives Dopamine - metabolism Fenthion - toxicity Homovanillic Acid - metabolism INSECTICIDAS INSECTICIDE INSECTICIDES Medical sciences Norepinephrine - metabolism Pesticides, fertilizers and other agrochemicals toxicology Pheochromocytoma - metabolism RAT RATA RATS Toxicology Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism
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