Potentiation of benzoate toxicity by glyoxylate: Inhibition of pyruvate carboxylase and the urea cycle

It has been proposed that administration of non-nitrogenous precursors to glycine is necessary to realize the full potential of benzoate metabolism as a pathway for disposal of waste nitrogen during ammonia intoxication (Coude et at., Clin Chim Acta 136: 211–217, 1984). However, when glyoxylate, a k...

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Veröffentlicht in:	Biochemical pharmacology 1989-09, Vol.38 (17), p.2919-2923
Hauptverfasser:	Cyr, Douglas M., Tremblay, George C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzoates - toxicity Benzoic Acid Biological and medical sciences Drug Synergism Drug toxicity and drugs side effects treatment Glyoxylates - pharmacology In Vitro Techniques Male Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Mitochondria, Liver - drug effects Mitochondria, Liver - enzymology Pharmacology. Drug treatments Pyruvate Carboxylase - antagonists & inhibitors Rats Rats, Inbred Strains Urea - metabolism
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