Randomized, Double-Blind Six-Month Trial of Prednisone in Duchenne's Muscular Dystrophy

We performed a randomized, double-blind, controlled six-month trial of prednisone in 103 boys with Duchenne's muscular dystrophy (age, 5 to 15 years). The patients were assigned to one of three regimens: prednisone, 0.75 mg per kilogram of body weight per day (n = 33); prednisone, 1.5 mg per ki...

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Veröffentlicht in:	The New England journal of medicine 1989-06, Vol.320 (24), p.1592-1597
Hauptverfasser:	Mendell, J.R, Moxley, R.T, Griggs, R.C, Brooke, M.H, Fenichel, G.M, Miller, J.P, King, W, Signore, L, Pandya, S, Florence, J, Schierbecker, J, Robison, J, Kaiser, K, Mandel, S, Arfken, C, Gilder, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Body weight Body weight gain Child Child, Preschool Clinical Trials as Topic Corticosteroids Creatinine Double-Blind Method Double-blind studies Duchenne's muscular dystrophy Evidence-based medicine Excretion Gene expression Humans Laboratories Lactose Male Muscle strength Muscles - drug effects Muscles - physiopathology Muscular Dystrophies - drug therapy Muscular Dystrophies - physiopathology Muscular dystrophy Musculoskeletal system Patients Prednisone Prednisone - administration & dosage Prednisone - adverse effects Prednisone - therapeutic use Protein synthesis Proteins Random Allocation Research centers Side effects Urine
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