Maternal alcohol ingestion inhibits fetal glucose uptake and growth
The distribution of maternally-derived glucose was determined in selected tissues of fetuses from ethanol-fed (EF) rats and from pair-fed (PF) and ad lib-fed (AF) controls. Maternal ethanol ingestion resulted in reduced fetal brain and liver weights and lower liver and lung glycogen levels compared...
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| Veröffentlicht in: | Neurotoxicology and teratology 1989-05, Vol.11 (3), p.215-219 |
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| container_title | Neurotoxicology and teratology |
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| creator | Singh, Sant P. Snyder, Ann K. Pullen, Gordon L. |
| description | The distribution of maternally-derived glucose was determined in selected tissues of fetuses from ethanol-fed (EF) rats and from pair-fed (PF) and ad lib-fed (AF) controls. Maternal ethanol ingestion resulted in reduced fetal brain and liver weights and lower liver and lung glycogen levels compared to those of the PF or AF control groups. In addition, experimental fetuses exhibited reduced uptake of maternally-derived [
3H] 2-deoxy-D-glucose (2-DG) by placenta and fetal brain. Fetal body, liver, lung, and brain weights correlated with fetal plasma
3H activity and with the fetal:maternal plasma
3H ratio, an indicator of the rate of placental glucose transfer. Brain weight correlated with 2-DG content per gram tissue weight. These observations suggest that reduced nutrient availability due to impaired placental transfer plays a role in the intrauterine growth retardation associated with maternal ethanol ingestion. |
| doi_str_mv | 10.1016/0892-0362(89)90061-5 |
| format | Article |
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3H] 2-deoxy-D-glucose (2-DG) by placenta and fetal brain. Fetal body, liver, lung, and brain weights correlated with fetal plasma
3H activity and with the fetal:maternal plasma
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3H] 2-deoxy-D-glucose (2-DG) by placenta and fetal brain. Fetal body, liver, lung, and brain weights correlated with fetal plasma
3H activity and with the fetal:maternal plasma
3H ratio, an indicator of the rate of placental glucose transfer. Brain weight correlated with 2-DG content per gram tissue weight. These observations suggest that reduced nutrient availability due to impaired placental transfer plays a role in the intrauterine growth retardation associated with maternal ethanol ingestion.</description><subject>Alcoholism and acute alcohol poisoning</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose</subject><subject>Brain - anatomy & histology</subject><subject>Brain - metabolism</subject><subject>Embryonic and Fetal Development - drug effects</subject><subject>Ethanol - adverse effects</subject><subject>Female</subject><subject>Fetus</subject><subject>Glucose - metabolism</subject><subject>Glucose uptake</subject><subject>Growth</subject><subject>Liver - anatomy & histology</subject><subject>Liver - metabolism</subject><subject>Lung - anatomy & histology</subject><subject>Lung - metabolism</subject><subject>Maternal alcohol ingestion</subject><subject>Maternal-Fetal Exchange</subject><subject>Medical sciences</subject><subject>Organ Size</subject><subject>Placenta - anatomy & histology</subject><subject>Placenta - metabolism</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Toxicology</subject><issn>0892-0362</issn><issn>1872-9738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlOwzAQQC0EKmX5A5ByQAgOgbGT2M4FCVVsUhEXOFsTx2kNaVzsBMTf49KqR04z0rzZHiEnFK4oUH4NsmQpZJxdyPKyBOA0LXbImErB0lJkcpeMt8g-OQjhHQAEpzAiIyaKIqdiTCbP2BvfYZtgq93ctYntZib01nUxm9vK9iFpTB-BWTtoF0wyLHv8MAl2dTLz7rufH5G9BttgjjfxkLzd371OHtPpy8PT5Haa6riqTxmikFhBA0gL2hRaVzXNKp3lrAFegNA1R5BSQoHYMDSMaVFnNdeioiIX2SE5X89devc5xCPVwgZt2hY744agaHyJy6yMYL4GtXcheNOopbcL9D-Kglq5UysxaiVGyVL9uVNFbDvdzB-qham3TRtZsX62qWPQ2DYeO23DFuNCCp6ziN2sMRNdfFnjVdDWdNrU1hvdq9rZ_-_4BcTViqk</recordid><startdate>19890501</startdate><enddate>19890501</enddate><creator>Singh, Sant P.</creator><creator>Snyder, Ann K.</creator><creator>Pullen, Gordon L.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19890501</creationdate><title>Maternal alcohol ingestion inhibits fetal glucose uptake and growth</title><author>Singh, Sant P. ; Snyder, Ann K. ; Pullen, Gordon L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-2aa78ab0f0a151f5ccbd13bc342f06507cd6a088805aaf2ae22c7d3d6c7b17473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Alcoholism and acute alcohol poisoning</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose</topic><topic>Brain - anatomy & histology</topic><topic>Brain - metabolism</topic><topic>Embryonic and Fetal Development - drug effects</topic><topic>Ethanol - adverse effects</topic><topic>Female</topic><topic>Fetus</topic><topic>Glucose - metabolism</topic><topic>Glucose uptake</topic><topic>Growth</topic><topic>Liver - anatomy & histology</topic><topic>Liver - metabolism</topic><topic>Lung - anatomy & histology</topic><topic>Lung - metabolism</topic><topic>Maternal alcohol ingestion</topic><topic>Maternal-Fetal Exchange</topic><topic>Medical sciences</topic><topic>Organ Size</topic><topic>Placenta - anatomy & histology</topic><topic>Placenta - metabolism</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singh, Sant P.</creatorcontrib><creatorcontrib>Snyder, Ann K.</creatorcontrib><creatorcontrib>Pullen, Gordon L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Neurotoxicology and teratology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Sant P.</au><au>Snyder, Ann K.</au><au>Pullen, Gordon L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal alcohol ingestion inhibits fetal glucose uptake and growth</atitle><jtitle>Neurotoxicology and teratology</jtitle><addtitle>Neurotoxicol Teratol</addtitle><date>1989-05-01</date><risdate>1989</risdate><volume>11</volume><issue>3</issue><spage>215</spage><epage>219</epage><pages>215-219</pages><issn>0892-0362</issn><eissn>1872-9738</eissn><coden>NETEEC</coden><abstract>The distribution of maternally-derived glucose was determined in selected tissues of fetuses from ethanol-fed (EF) rats and from pair-fed (PF) and ad lib-fed (AF) controls. Maternal ethanol ingestion resulted in reduced fetal brain and liver weights and lower liver and lung glycogen levels compared to those of the PF or AF control groups. In addition, experimental fetuses exhibited reduced uptake of maternally-derived [
3H] 2-deoxy-D-glucose (2-DG) by placenta and fetal brain. Fetal body, liver, lung, and brain weights correlated with fetal plasma
3H activity and with the fetal:maternal plasma
3H ratio, an indicator of the rate of placental glucose transfer. Brain weight correlated with 2-DG content per gram tissue weight. These observations suggest that reduced nutrient availability due to impaired placental transfer plays a role in the intrauterine growth retardation associated with maternal ethanol ingestion.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2755417</pmid><doi>10.1016/0892-0362(89)90061-5</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0892-0362 |
| ispartof | Neurotoxicology and teratology, 1989-05, Vol.11 (3), p.215-219 |
| issn | 0892-0362 1872-9738 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Alcoholism and acute alcohol poisoning Animals Biological and medical sciences Blood Glucose Brain - anatomy & histology Brain - metabolism Embryonic and Fetal Development - drug effects Ethanol - adverse effects Female Fetus Glucose - metabolism Glucose uptake Growth Liver - anatomy & histology Liver - metabolism Lung - anatomy & histology Lung - metabolism Maternal alcohol ingestion Maternal-Fetal Exchange Medical sciences Organ Size Placenta - anatomy & histology Placenta - metabolism Pregnancy Rats Rats, Inbred Strains Toxicology |
| title | Maternal alcohol ingestion inhibits fetal glucose uptake and growth |
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