Impact of lung surfactant on wettability and cytotoxicity of nanoparticles
The importance of nanoparticle characterization for nanotoxicology has been extensively emphasized and it has been universally agreed that the most important parameters for characterizing nanomaterials are specific surface area and surface properties (chemistry, hydro-philicity/phobicity, charge etc...
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| Veröffentlicht in: | RSC advances 2014-01, Vol.4 (39), p.20573-20581 |
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| container_title | RSC advances |
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| creator | Ratoi, Monica Hoet, Peter H. M. Crossley, Alison Dobson, Peter |
| description | The importance of nanoparticle characterization for nanotoxicology has been extensively emphasized and it has been universally agreed that the most important parameters for characterizing nanomaterials are specific surface area and surface properties (chemistry, hydro-philicity/phobicity, charge
etc.
). This study is proposing the use of enthalpy of wetting which depends on both specific surface area and surface properties, is easily measurable and proves to be highly relevant for predicting nanoparticles' dispersion state and their interaction with the lungs. It also shows the conditioning effect of the lung surfactant main component, DPPC on the surface of particles when used in concentrations which mimic pulmonary exposure more closely. |
| doi_str_mv | 10.1039/C3RA47374K |
| format | Article |
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etc.
). This study is proposing the use of enthalpy of wetting which depends on both specific surface area and surface properties, is easily measurable and proves to be highly relevant for predicting nanoparticles' dispersion state and their interaction with the lungs. It also shows the conditioning effect of the lung surfactant main component, DPPC on the surface of particles when used in concentrations which mimic pulmonary exposure more closely.</description><identifier>ISSN: 2046-2069</identifier><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/C3RA47374K</identifier><language>eng</language><subject>Dispersions ; Lungs ; Nanomaterials ; Nanoparticles ; Nanostructure ; Specific surface ; Surface properties ; Surfactants</subject><ispartof>RSC advances, 2014-01, Vol.4 (39), p.20573-20581</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-f93bfd237d06a5bbf5f071789b9483590f0001667b01af26e8412dba164030443</citedby><cites>FETCH-LOGICAL-c366t-f93bfd237d06a5bbf5f071789b9483590f0001667b01af26e8412dba164030443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Ratoi, Monica</creatorcontrib><creatorcontrib>Hoet, Peter H. M.</creatorcontrib><creatorcontrib>Crossley, Alison</creatorcontrib><creatorcontrib>Dobson, Peter</creatorcontrib><title>Impact of lung surfactant on wettability and cytotoxicity of nanoparticles</title><title>RSC advances</title><description>The importance of nanoparticle characterization for nanotoxicology has been extensively emphasized and it has been universally agreed that the most important parameters for characterizing nanomaterials are specific surface area and surface properties (chemistry, hydro-philicity/phobicity, charge
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). This study is proposing the use of enthalpy of wetting which depends on both specific surface area and surface properties, is easily measurable and proves to be highly relevant for predicting nanoparticles' dispersion state and their interaction with the lungs. It also shows the conditioning effect of the lung surfactant main component, DPPC on the surface of particles when used in concentrations which mimic pulmonary exposure more closely.</description><subject>Dispersions</subject><subject>Lungs</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Nanostructure</subject><subject>Specific surface</subject><subject>Surface properties</subject><subject>Surfactants</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNpNkEFLxDAQhYMouKx78Rf0KEI1k6Rpe1wWdVcXBNFzSdJEKm1SkxTtvzfLCjqXmXl88xgeQpeAbwDT-nZDX9aspCV7OkELghnPCeb16b_5HK1C-MCpeAGEwwI97oZRqJg5k_WTfc_C5E3ahU2Szb50jEJ2fRfnTNg2U3N00X136iCkEyusG4WPnep1uEBnRvRBr377Er3d371utvn--WG3We9zRTmPuampNC2hZYu5KKQ0hcEllFUta1bRosYmvQeclxKDMITrigFppQDOMMWM0SW6OvqO3n1OOsRm6ILSfS-sdlNooGDAikRDQq-PqPIuBK9NM_puEH5uADeHzJq_zOgPPTpdsg</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Ratoi, Monica</creator><creator>Hoet, Peter H. M.</creator><creator>Crossley, Alison</creator><creator>Dobson, Peter</creator><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20140101</creationdate><title>Impact of lung surfactant on wettability and cytotoxicity of nanoparticles</title><author>Ratoi, Monica ; Hoet, Peter H. M. ; Crossley, Alison ; Dobson, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-f93bfd237d06a5bbf5f071789b9483590f0001667b01af26e8412dba164030443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Dispersions</topic><topic>Lungs</topic><topic>Nanomaterials</topic><topic>Nanoparticles</topic><topic>Nanostructure</topic><topic>Specific surface</topic><topic>Surface properties</topic><topic>Surfactants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ratoi, Monica</creatorcontrib><creatorcontrib>Hoet, Peter H. M.</creatorcontrib><creatorcontrib>Crossley, Alison</creatorcontrib><creatorcontrib>Dobson, Peter</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ratoi, Monica</au><au>Hoet, Peter H. M.</au><au>Crossley, Alison</au><au>Dobson, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of lung surfactant on wettability and cytotoxicity of nanoparticles</atitle><jtitle>RSC advances</jtitle><date>2014-01-01</date><risdate>2014</risdate><volume>4</volume><issue>39</issue><spage>20573</spage><epage>20581</epage><pages>20573-20581</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>The importance of nanoparticle characterization for nanotoxicology has been extensively emphasized and it has been universally agreed that the most important parameters for characterizing nanomaterials are specific surface area and surface properties (chemistry, hydro-philicity/phobicity, charge
etc.
). This study is proposing the use of enthalpy of wetting which depends on both specific surface area and surface properties, is easily measurable and proves to be highly relevant for predicting nanoparticles' dispersion state and their interaction with the lungs. It also shows the conditioning effect of the lung surfactant main component, DPPC on the surface of particles when used in concentrations which mimic pulmonary exposure more closely.</abstract><doi>10.1039/C3RA47374K</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2046-2069 |
| ispartof | RSC advances, 2014-01, Vol.4 (39), p.20573-20581 |
| issn | 2046-2069 2046-2069 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1541456401 |
| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Dispersions Lungs Nanomaterials Nanoparticles Nanostructure Specific surface Surface properties Surfactants |
| title | Impact of lung surfactant on wettability and cytotoxicity of nanoparticles |
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