Comparative in vivo assessment of the subacute toxicity of gold and silver nanoparticles
In spite of the projected therapeutic potentials of gold nanoparticles (GNP) and silver nanoparticles (SNP), very limited data are available on the interaction of nanoparticles with the biological systems. The present investigation was designed to evaluate as well as compare the subacute toxicity of...
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| Veröffentlicht in: | Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2014-04, Vol.16 (4), p.1-12, Article 2338 |
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| creator | Rathore, Mansee Mohanty, Ipseeta Ray Maheswari, Ujjwala Dayal, Navami Suman, Rajesh Joshi, D. S. |
| description | In spite of the projected therapeutic potentials of gold nanoparticles (GNP) and silver nanoparticles (SNP), very limited data are available on the interaction of nanoparticles with the biological systems. The present investigation was designed to evaluate as well as compare the subacute toxicity of GNP and SNP. Stable suspensions of GNP and SNP with mean particle diameter 10 and 25 nm, respectively, were prepared. Wistar rats were orally fed SNP (3 mg/kg) or GNP (20 μg/kg), once a day for 21 days. Biochemical indices (creatinine phosphokinase-MB, urea, blood urea nitrogen, aspartate transaminase, alkaline alanine transferase) and histopathological features of the liver, heart, brain, lungs, and kidney were evaluated for signs of toxicity. A significant decline in hepatic and renal function in the GNP treated group was observed as compared to SNP. GNP was found to be relatively more toxic on the lungs and SNP on the myocardial tissue as compared to SNP and GNP treatments, respectively. Interestingly, neither SNP nor GNP adversely affected the basal architecture of the brain as compared to sham. The present study demonstrated that GNP was significantly more noxious on the liver and kidney as compared with SNP. |
| doi_str_mv | 10.1007/s11051-014-2338-x |
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S.</creator><creatorcontrib>Rathore, Mansee ; Mohanty, Ipseeta Ray ; Maheswari, Ujjwala ; Dayal, Navami ; Suman, Rajesh ; Joshi, D. S.</creatorcontrib><description>In spite of the projected therapeutic potentials of gold nanoparticles (GNP) and silver nanoparticles (SNP), very limited data are available on the interaction of nanoparticles with the biological systems. The present investigation was designed to evaluate as well as compare the subacute toxicity of GNP and SNP. Stable suspensions of GNP and SNP with mean particle diameter 10 and 25 nm, respectively, were prepared. Wistar rats were orally fed SNP (3 mg/kg) or GNP (20 μg/kg), once a day for 21 days. Biochemical indices (creatinine phosphokinase-MB, urea, blood urea nitrogen, aspartate transaminase, alkaline alanine transferase) and histopathological features of the liver, heart, brain, lungs, and kidney were evaluated for signs of toxicity. A significant decline in hepatic and renal function in the GNP treated group was observed as compared to SNP. GNP was found to be relatively more toxic on the lungs and SNP on the myocardial tissue as compared to SNP and GNP treatments, respectively. Interestingly, neither SNP nor GNP adversely affected the basal architecture of the brain as compared to sham. 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S.</creatorcontrib><title>Comparative in vivo assessment of the subacute toxicity of gold and silver nanoparticles</title><title>Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology</title><addtitle>J Nanopart Res</addtitle><description>In spite of the projected therapeutic potentials of gold nanoparticles (GNP) and silver nanoparticles (SNP), very limited data are available on the interaction of nanoparticles with the biological systems. The present investigation was designed to evaluate as well as compare the subacute toxicity of GNP and SNP. Stable suspensions of GNP and SNP with mean particle diameter 10 and 25 nm, respectively, were prepared. Wistar rats were orally fed SNP (3 mg/kg) or GNP (20 μg/kg), once a day for 21 days. Biochemical indices (creatinine phosphokinase-MB, urea, blood urea nitrogen, aspartate transaminase, alkaline alanine transferase) and histopathological features of the liver, heart, brain, lungs, and kidney were evaluated for signs of toxicity. A significant decline in hepatic and renal function in the GNP treated group was observed as compared to SNP. GNP was found to be relatively more toxic on the lungs and SNP on the myocardial tissue as compared to SNP and GNP treatments, respectively. Interestingly, neither SNP nor GNP adversely affected the basal architecture of the brain as compared to sham. The present study demonstrated that GNP was significantly more noxious on the liver and kidney as compared with SNP.</description><subject>Biocompatibility</subject><subject>Brain</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry and Materials Science</subject><subject>Cross-disciplinary physics: materials science; rheology</subject><subject>Exact sciences and technology</subject><subject>Gold</subject><subject>Inorganic Chemistry</subject><subject>Kidneys</subject><subject>Lasers</subject><subject>Liver</subject><subject>Materials Science</subject><subject>Nanocrystalline materials</subject><subject>Nanoparticles</subject><subject>Nanoscale materials and structures: fabrication and characterization</subject><subject>Nanotechnology</subject><subject>Optical Devices</subject><subject>Optics</subject><subject>Photonics</subject><subject>Physical Chemistry</subject><subject>Physics</subject><subject>Renal function</subject><subject>Research Paper</subject><subject>Silver</subject><subject>Subacute toxicity</subject><subject>Toxicity</subject><subject>Urea</subject><issn>1388-0764</issn><issn>1572-896X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kEtrHDEQhAeTQBwnPyA3QQj4Mraeo9HRLPEDDL4k4JvQaHpsmVlpo9Ys638fLWuMMfjUDfV1VVNN84PRM0apPkfGqGItZbLlQvTt7qg5Zkrztjfd_ae6i75vqe7kl-Yr4hOlrOOGHzf3q7TeuOxK2AIJkWzDNhGHCIhriIWkiZRHILgMzi8FSEm74EN53gsPaR6JiyPBMG8hk-hiql4l-BnwW_N5cjPC95d50vy9_P1ndd3e3l3drC5uWy-0Ka3uYXBi5FwDSNFrYEayrqeGc6Go1macwPjJUOcGOY1ylLLT0g1G8VG4wYuT5vTgu8np3wJY7Dqgh3l2EdKClinJpKLGiIr-fIc-pSXH-l2lmNQ1Ve0pdqB8TogZJrvJYe3ys2XU7ru2h65t7druu7a7evPrxdmhd_OUXfQBXw95L2q8UpXjBw6rFB8gv_ngQ_P_QbOPTw</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Rathore, Mansee</creator><creator>Mohanty, Ipseeta Ray</creator><creator>Maheswari, Ujjwala</creator><creator>Dayal, Navami</creator><creator>Suman, Rajesh</creator><creator>Joshi, D. 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Wistar rats were orally fed SNP (3 mg/kg) or GNP (20 μg/kg), once a day for 21 days. Biochemical indices (creatinine phosphokinase-MB, urea, blood urea nitrogen, aspartate transaminase, alkaline alanine transferase) and histopathological features of the liver, heart, brain, lungs, and kidney were evaluated for signs of toxicity. A significant decline in hepatic and renal function in the GNP treated group was observed as compared to SNP. GNP was found to be relatively more toxic on the lungs and SNP on the myocardial tissue as compared to SNP and GNP treatments, respectively. Interestingly, neither SNP nor GNP adversely affected the basal architecture of the brain as compared to sham. The present study demonstrated that GNP was significantly more noxious on the liver and kidney as compared with SNP.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s11051-014-2338-x</doi><tpages>12</tpages></addata></record> |
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| subjects | Biocompatibility Brain Characterization and Evaluation of Materials Chemistry and Materials Science Cross-disciplinary physics: materials science rheology Exact sciences and technology Gold Inorganic Chemistry Kidneys Lasers Liver Materials Science Nanocrystalline materials Nanoparticles Nanoscale materials and structures: fabrication and characterization Nanotechnology Optical Devices Optics Photonics Physical Chemistry Physics Renal function Research Paper Silver Subacute toxicity Toxicity Urea |
| title | Comparative in vivo assessment of the subacute toxicity of gold and silver nanoparticles |
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