In vitro degradation and drug-release behavior of electrospun, fibrous webs of poly(lactic-co-glycolic acid)

Ultrafine fibrous webs of poly(lactide‐co‐glycolic acid) (PLGA) containing the bactericidal antibiotic drug rifampin were prepared by electrospinning, and their properties were investigated for wound‐dressing applications. Because PLGA is a biodegradable and biocompatible polymer, it is one of the b...

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Veröffentlicht in:Journal of applied polymer science 2012-04, Vol.124 (1), p.209-214
Hauptverfasser: Hong, Kyung Hwa, Woo, Seok Hoon, Kang, Tae Jin
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Woo, Seok Hoon
Kang, Tae Jin
description Ultrafine fibrous webs of poly(lactide‐co‐glycolic acid) (PLGA) containing the bactericidal antibiotic drug rifampin were prepared by electrospinning, and their properties were investigated for wound‐dressing applications. Because PLGA is a biodegradable and biocompatible polymer, it is one of the best materials for the preparation of wound‐dressing substrates. Through this investigation of PLGA/rifampin electrospun webs, we found that the in vitro degradation reached approximately 60% in 10 days, and the drug release from the webs showed a fast and constant profile suitable for wound‐dressing applications. Also, we observed that both the web‐degradation rate and the drug‐release rate increased as the drug concentration in the PLGA/rifampin electrospun webs and the content level of glycolide units in the PLGA polymer matrix increased. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
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Appl. Polym. Sci</addtitle><description>Ultrafine fibrous webs of poly(lactide‐co‐glycolic acid) (PLGA) containing the bactericidal antibiotic drug rifampin were prepared by electrospinning, and their properties were investigated for wound‐dressing applications. Because PLGA is a biodegradable and biocompatible polymer, it is one of the best materials for the preparation of wound‐dressing substrates. Through this investigation of PLGA/rifampin electrospun webs, we found that the in vitro degradation reached approximately 60% in 10 days, and the drug release from the webs showed a fast and constant profile suitable for wound‐dressing applications. Also, we observed that both the web‐degradation rate and the drug‐release rate increased as the drug concentration in the PLGA/rifampin electrospun webs and the content level of glycolide units in the PLGA polymer matrix increased. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012</description><subject>Antibiotics</subject><subject>Applied sciences</subject><subject>Biocompatibility</subject><subject>Biodegradability</subject><subject>biodegradable</subject><subject>Biological and medical sciences</subject><subject>Degradation</subject><subject>drug delivery systems</subject><subject>Drugs</subject><subject>Electrospinning</subject><subject>Exact sciences and technology</subject><subject>fibers</subject><subject>Fibers and threads</subject><subject>Forms of application and semi-finished materials</subject><subject>In vitro testing</subject><subject>Materials science</subject><subject>Medical sciences</subject><subject>Polymer industry, paints, wood</subject><subject>Polymers</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology of polymers</subject><subject>Technology. Biomaterials. 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Also, we observed that both the web‐degradation rate and the drug‐release rate increased as the drug concentration in the PLGA/rifampin electrospun webs and the content level of glycolide units in the PLGA polymer matrix increased. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><doi>10.1002/app.33357</doi><tpages>6</tpages></addata></record>
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subjects Antibiotics
Applied sciences
Biocompatibility
Biodegradability
biodegradable
Biological and medical sciences
Degradation
drug delivery systems
Drugs
Electrospinning
Exact sciences and technology
fibers
Fibers and threads
Forms of application and semi-finished materials
In vitro testing
Materials science
Medical sciences
Polymer industry, paints, wood
Polymers
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology of polymers
Technology. Biomaterials. Equipments
Webs
title In vitro degradation and drug-release behavior of electrospun, fibrous webs of poly(lactic-co-glycolic acid)
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