In vitro degradation and drug-release behavior of electrospun, fibrous webs of poly(lactic-co-glycolic acid)
Ultrafine fibrous webs of poly(lactide‐co‐glycolic acid) (PLGA) containing the bactericidal antibiotic drug rifampin were prepared by electrospinning, and their properties were investigated for wound‐dressing applications. Because PLGA is a biodegradable and biocompatible polymer, it is one of the b...
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description | Ultrafine fibrous webs of poly(lactide‐co‐glycolic acid) (PLGA) containing the bactericidal antibiotic drug rifampin were prepared by electrospinning, and their properties were investigated for wound‐dressing applications. Because PLGA is a biodegradable and biocompatible polymer, it is one of the best materials for the preparation of wound‐dressing substrates. Through this investigation of PLGA/rifampin electrospun webs, we found that the in vitro degradation reached approximately 60% in 10 days, and the drug release from the webs showed a fast and constant profile suitable for wound‐dressing applications. Also, we observed that both the web‐degradation rate and the drug‐release rate increased as the drug concentration in the PLGA/rifampin electrospun webs and the content level of glycolide units in the PLGA polymer matrix increased. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012 |
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Because PLGA is a biodegradable and biocompatible polymer, it is one of the best materials for the preparation of wound‐dressing substrates. Through this investigation of PLGA/rifampin electrospun webs, we found that the in vitro degradation reached approximately 60% in 10 days, and the drug release from the webs showed a fast and constant profile suitable for wound‐dressing applications. Also, we observed that both the web‐degradation rate and the drug‐release rate increased as the drug concentration in the PLGA/rifampin electrospun webs and the content level of glycolide units in the PLGA polymer matrix increased. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012</description><identifier>ISSN: 0021-8995</identifier><identifier>EISSN: 1097-4628</identifier><identifier>DOI: 10.1002/app.33357</identifier><identifier>CODEN: JAPNAB</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Antibiotics ; Applied sciences ; Biocompatibility ; Biodegradability ; biodegradable ; Biological and medical sciences ; Degradation ; drug delivery systems ; Drugs ; Electrospinning ; Exact sciences and technology ; fibers ; Fibers and threads ; Forms of application and semi-finished materials ; In vitro testing ; Materials science ; Medical sciences ; Polymer industry, paints, wood ; Polymers ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology of polymers ; Technology. Biomaterials. 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Appl. Polym. Sci</addtitle><description>Ultrafine fibrous webs of poly(lactide‐co‐glycolic acid) (PLGA) containing the bactericidal antibiotic drug rifampin were prepared by electrospinning, and their properties were investigated for wound‐dressing applications. Because PLGA is a biodegradable and biocompatible polymer, it is one of the best materials for the preparation of wound‐dressing substrates. Through this investigation of PLGA/rifampin electrospun webs, we found that the in vitro degradation reached approximately 60% in 10 days, and the drug release from the webs showed a fast and constant profile suitable for wound‐dressing applications. Also, we observed that both the web‐degradation rate and the drug‐release rate increased as the drug concentration in the PLGA/rifampin electrospun webs and the content level of glycolide units in the PLGA polymer matrix increased. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012</description><subject>Antibiotics</subject><subject>Applied sciences</subject><subject>Biocompatibility</subject><subject>Biodegradability</subject><subject>biodegradable</subject><subject>Biological and medical sciences</subject><subject>Degradation</subject><subject>drug delivery systems</subject><subject>Drugs</subject><subject>Electrospinning</subject><subject>Exact sciences and technology</subject><subject>fibers</subject><subject>Fibers and threads</subject><subject>Forms of application and semi-finished materials</subject><subject>In vitro testing</subject><subject>Materials science</subject><subject>Medical sciences</subject><subject>Polymer industry, paints, wood</subject><subject>Polymers</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology of polymers</subject><subject>Technology. Biomaterials. Equipments</subject><subject>Webs</subject><issn>0021-8995</issn><issn>1097-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp1kEFv1DAQhS0EEkvhwD-whJBaibS2YzvJsVrBUqigBxBHa-KMFxc3DnbSsv8eL1t6QOJkjed7b2YeIS85O-WMiTOYptO6rlXziKw465pKatE-JqvS41XbdeopeZbzNWOcK6ZXJFyM9NbPKdIBtwkGmH0cKYwDHdKyrRIGhIy0x-9w62Oi0dHyZYsgT8v4hjrfp7hkeod93jenGHbHAezsbWVjtQ07G4O3FKwfTp6TJw5Cxhf37xH5-u7tl_X76vLz5mJ9fllZqWVToUQJDMFyzYXsh3qwyFrNobW9GzQrV_RNr2tRanSdQFDdoJrWWc5F53h9RI4PvlOKPxfMs7nx2WIIMGJZ1nAluZRN2-qCvvoHvY5LGst2heK6a0XHWKFODpQtd-eEzkzJ30DaGc7MPndTcjd_ci_s63tHyBaCSzBanx8EQineKL2ffHbg7nzA3f8NzfnV1V_n6qDwecZfDwpIP4xu6kaZb5825iMTH9Z6owyrfwOME6B8</recordid><startdate>20120405</startdate><enddate>20120405</enddate><creator>Hong, Kyung Hwa</creator><creator>Woo, Seok Hoon</creator><creator>Kang, Tae Jin</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><scope>FR3</scope><scope>KR7</scope></search><sort><creationdate>20120405</creationdate><title>In vitro degradation and drug-release behavior of electrospun, fibrous webs of poly(lactic-co-glycolic acid)</title><author>Hong, Kyung Hwa ; Woo, Seok Hoon ; Kang, Tae Jin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4647-e4e4a0eac16124bd3dce0861a8cbfd60995b7b6328cbef92ea59d578fc1129f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Antibiotics</topic><topic>Applied sciences</topic><topic>Biocompatibility</topic><topic>Biodegradability</topic><topic>biodegradable</topic><topic>Biological and medical sciences</topic><topic>Degradation</topic><topic>drug delivery systems</topic><topic>Drugs</topic><topic>Electrospinning</topic><topic>Exact sciences and technology</topic><topic>fibers</topic><topic>Fibers and threads</topic><topic>Forms of application and semi-finished materials</topic><topic>In vitro testing</topic><topic>Materials science</topic><topic>Medical sciences</topic><topic>Polymer industry, paints, wood</topic><topic>Polymers</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Technology of polymers</topic><topic>Technology. Biomaterials. Equipments</topic><topic>Webs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hong, Kyung Hwa</creatorcontrib><creatorcontrib>Woo, Seok Hoon</creatorcontrib><creatorcontrib>Kang, Tae Jin</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><jtitle>Journal of applied polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hong, Kyung Hwa</au><au>Woo, Seok Hoon</au><au>Kang, Tae Jin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro degradation and drug-release behavior of electrospun, fibrous webs of poly(lactic-co-glycolic acid)</atitle><jtitle>Journal of applied polymer science</jtitle><addtitle>J. Appl. Polym. Sci</addtitle><date>2012-04-05</date><risdate>2012</risdate><volume>124</volume><issue>1</issue><spage>209</spage><epage>214</epage><pages>209-214</pages><issn>0021-8995</issn><eissn>1097-4628</eissn><coden>JAPNAB</coden><abstract>Ultrafine fibrous webs of poly(lactide‐co‐glycolic acid) (PLGA) containing the bactericidal antibiotic drug rifampin were prepared by electrospinning, and their properties were investigated for wound‐dressing applications. Because PLGA is a biodegradable and biocompatible polymer, it is one of the best materials for the preparation of wound‐dressing substrates. Through this investigation of PLGA/rifampin electrospun webs, we found that the in vitro degradation reached approximately 60% in 10 days, and the drug release from the webs showed a fast and constant profile suitable for wound‐dressing applications. Also, we observed that both the web‐degradation rate and the drug‐release rate increased as the drug concentration in the PLGA/rifampin electrospun webs and the content level of glycolide units in the PLGA polymer matrix increased. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><doi>10.1002/app.33357</doi><tpages>6</tpages></addata></record> |
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subjects | Antibiotics Applied sciences Biocompatibility Biodegradability biodegradable Biological and medical sciences Degradation drug delivery systems Drugs Electrospinning Exact sciences and technology fibers Fibers and threads Forms of application and semi-finished materials In vitro testing Materials science Medical sciences Polymer industry, paints, wood Polymers Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology of polymers Technology. Biomaterials. Equipments Webs |
title | In vitro degradation and drug-release behavior of electrospun, fibrous webs of poly(lactic-co-glycolic acid) |
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