Probiotic Lactobacillus rhamnosus GR-1 supernatant prevents lipopolysaccharide-induced preterm birth and reduces inflammation in pregnant CD-1 mice

Objective The objective of this study was to determine the effect of probiotic Lactobacillus rhamnosus GR-1 supernatant (GR-1 SN) on lipopolysaccharide-induced preterm birth (PTB) and outputs of cytokines, chemokines, and progesterone in pregnant CD-1 mice. Study Design We compared PTB rates after i...

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Veröffentlicht in:	American journal of obstetrics and gynecology 2014-07, Vol.211 (1), p.44.e1-44.e12
Hauptverfasser:	Yang, Siwen, HBSc, Li, Wei, PhD, Challis, John R.G., PhD, Reid, Gregor, PhD, MBA, Kim, Sung O., PhD, Bocking, Alan D., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - metabolism chemokine Chemokines - metabolism cytokine Cytokines - metabolism Enzyme-Linked Immunosorbent Assay Female Inflammation - diagnosis Inflammation - etiology Inflammation - metabolism Inflammation - prevention & control Lactobacillus rhamnosus Lactobacillus rhamnosus GR-1 Lipopolysaccharides Mice Mice, Inbred ICR Multiplex Polymerase Chain Reaction Obstetrics and Gynecology Pregnancy Pregnancy Complications - diagnosis Pregnancy Complications - etiology Pregnancy Complications - metabolism Pregnancy Complications - prevention & control Premature Birth - etiology Premature Birth - prevention & control preterm birth Probiotics - therapeutic use progesterone Progesterone - metabolism Random Allocation Sex Ratio
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