Developmental language disability as a consequence of prenatal exposure to ethanol
Two pre-school-aged patients with a history of prenatal exposure to ethanol had abnormal head size and developmental delay. Both children were strikingly similar in physical appearance, behavior, and cognitive dysfunction. Facial features were typical of fetal alcohol syndrome. Head circumference gr...
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| Veröffentlicht in: | Pediatrics (Evanston) 1981-12, Vol.68 (6), p.850-855 |
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| container_title | Pediatrics (Evanston) |
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| creator | Shaywitz, S E Caparulo, B K Hodgson, E S |
| description | Two pre-school-aged patients with a history of prenatal exposure to ethanol had abnormal head size and developmental delay. Both children were strikingly similar in physical appearance, behavior, and cognitive dysfunction. Facial features were typical of fetal alcohol syndrome. Head circumference greater than 97th percentile without hydrocephalus and no evidence of prenatal or postnatal growth failure were unusual for ethanol teratogenicity. Each child had a similar pattern of verbal and behavioral dysfunctions characterized by (1) marked hypervigilence, (2) distractability, and (3) cognitive confusion manifested as anxiety and behavioral disorganization. It is suggested that a history of prenatal exposure to ethanol associated with (1) large head circumference, (2) facial features of fetal alcohol syndrome, and (3) early developmental delay, particularly in language acquisition, and impaired modulation of attention and arousal may represent a possible new effect of alcohol teratogenicity. |
| doi_str_mv | 10.1542/peds.68.6.850 |
| format | Article |
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Both children were strikingly similar in physical appearance, behavior, and cognitive dysfunction. Facial features were typical of fetal alcohol syndrome. Head circumference greater than 97th percentile without hydrocephalus and no evidence of prenatal or postnatal growth failure were unusual for ethanol teratogenicity. Each child had a similar pattern of verbal and behavioral dysfunctions characterized by (1) marked hypervigilence, (2) distractability, and (3) cognitive confusion manifested as anxiety and behavioral disorganization. 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Both children were strikingly similar in physical appearance, behavior, and cognitive dysfunction. Facial features were typical of fetal alcohol syndrome. Head circumference greater than 97th percentile without hydrocephalus and no evidence of prenatal or postnatal growth failure were unusual for ethanol teratogenicity. Each child had a similar pattern of verbal and behavioral dysfunctions characterized by (1) marked hypervigilence, (2) distractability, and (3) cognitive confusion manifested as anxiety and behavioral disorganization. It is suggested that a history of prenatal exposure to ethanol associated with (1) large head circumference, (2) facial features of fetal alcohol syndrome, and (3) early developmental delay, particularly in language acquisition, and impaired modulation of attention and arousal may represent a possible new effect of alcohol teratogenicity.</description><subject>Child, Preschool</subject><subject>Cognition - drug effects</subject><subject>Ethanol - adverse effects</subject><subject>Face</subject><subject>Female</subject><subject>Fetal Alcohol Spectrum Disorders - complications</subject><subject>Humans</subject><subject>Language Development Disorders - chemically induced</subject><subject>Language Development Disorders - etiology</subject><subject>Language Disorders - etiology</subject><subject>Male</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LxDAQhoMo67p69Cjk5K3rJM1H9yh-w4Igeg5JOl0rbVObVtx_b5ZdPA0Mz7zM-xByyWDJpOA3PZZxqYqlWhYSjsicwarIBNfymMwBcpYJAHlKzmL8AgAhNZ-Rmc451zyfk7d7_MEm9C12o21oY7vNZDdIyzpaVzf1uKU2Ukt96CJ-T9h5pKGi_YCd3R3gbx_iNCAdA8Xx03ahOScnlW0iXhzmgnw8PrzfPWfr16eXu9t15nO2GjMutarsyjoQFitbeiehcMKnNchEgBC6YtIq7UtwSmpnsZTAnEo9C1_mC3K9z-2HkD6Lo2nr6LFJHTBM0SQ7jDORJzDbg34IMQ5YmX6oWztsDYMdxc3OoVGFUSZlJ_7qEDy5Fst_-iAt_wN89m5n</recordid><startdate>198112</startdate><enddate>198112</enddate><creator>Shaywitz, S E</creator><creator>Caparulo, B K</creator><creator>Hodgson, E S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>198112</creationdate><title>Developmental language disability as a consequence of prenatal exposure to ethanol</title><author>Shaywitz, S E ; Caparulo, B K ; Hodgson, E S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-2576fa9ab04aefadcb508b4c576053190447f15a67cd0b657baed501b68508cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Child, Preschool</topic><topic>Cognition - drug effects</topic><topic>Ethanol - adverse effects</topic><topic>Face</topic><topic>Female</topic><topic>Fetal Alcohol Spectrum Disorders - complications</topic><topic>Humans</topic><topic>Language Development Disorders - chemically induced</topic><topic>Language Development Disorders - etiology</topic><topic>Language Disorders - etiology</topic><topic>Male</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shaywitz, S E</creatorcontrib><creatorcontrib>Caparulo, B K</creatorcontrib><creatorcontrib>Hodgson, E S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shaywitz, S E</au><au>Caparulo, B K</au><au>Hodgson, E S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Developmental language disability as a consequence of prenatal exposure to ethanol</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>1981-12</date><risdate>1981</risdate><volume>68</volume><issue>6</issue><spage>850</spage><epage>855</epage><pages>850-855</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><abstract>Two pre-school-aged patients with a history of prenatal exposure to ethanol had abnormal head size and developmental delay. Both children were strikingly similar in physical appearance, behavior, and cognitive dysfunction. Facial features were typical of fetal alcohol syndrome. Head circumference greater than 97th percentile without hydrocephalus and no evidence of prenatal or postnatal growth failure were unusual for ethanol teratogenicity. Each child had a similar pattern of verbal and behavioral dysfunctions characterized by (1) marked hypervigilence, (2) distractability, and (3) cognitive confusion manifested as anxiety and behavioral disorganization. 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| ispartof | Pediatrics (Evanston), 1981-12, Vol.68 (6), p.850-855 |
| issn | 0031-4005 1098-4275 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Child, Preschool Cognition - drug effects Ethanol - adverse effects Face Female Fetal Alcohol Spectrum Disorders - complications Humans Language Development Disorders - chemically induced Language Development Disorders - etiology Language Disorders - etiology Male Pregnancy Prenatal Exposure Delayed Effects |
| title | Developmental language disability as a consequence of prenatal exposure to ethanol |
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