Serine–arginine protein kinase 1 is associated with breast cancer progression and poor patient survival
Breast cancer is the most common cancer and the second leading cause of mortality for women worldwide. It is necessary to identify valuable molecular markers to predict breast cancer progression in patients and treatment effect. Serine–arginine protein kinase 1 (SRPK1), a member of SR kinase family,...
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| Veröffentlicht in: | Medical oncology (Northwood, London, England) London, England), 2014-08, Vol.31 (8), p.83-83, Article 83 |
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| container_title | Medical oncology (Northwood, London, England) |
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| creator | Li, Xing-hua Song, Jun-wei Liu, Jun-ling Wu, Shu Wang, Le-shi Gong, Li-yun Lin, Xi |
| description | Breast cancer is the most common cancer and the second leading cause of mortality for women worldwide. It is necessary to identify valuable molecular markers to predict breast cancer progression in patients and treatment effect. Serine–arginine protein kinase 1 (SRPK1), a member of SR kinase family, phosphorylates the SR splicing factors which plays essential roles in normal cell development and multiple human diseases. In the current study, we wanted to explore if there are any relationships between SRPK1 expression in breast cancer and its clinical characteristics. The results showed that SRPK1 is upregulated in breast cancer cell lines and tissues at both mRNA and protein levels, measured by quantitative reverse transcriptase PCR and Western blotting. Immunohistochemical analysis showed a high expression of SRPK1 in 132 paraffin samples of patients with breast cancer; statistical analyses demonstrated that high expression of SRPK1 significantly correlated with clinical staging of patients with breast cancer (
P
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| doi_str_mv | 10.1007/s12032-014-0083-8 |
| format | Article |
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P
< 0.001), TNM classification (
P
< 0.05). Low expression of SRPK1 leads to longer survival time, while high expression of SRPK1 leads to shorter survival time of patients. Multivariate analysis revealed that upregulation of SRPK1 might be an independent prognostic marker for the outcomes of patients with breast cancer. In conclusion, upregulation of SRPK1 might play an important role in the progression of breast cancer and might be considered as the potential diagnostic and therapeutic target to this malignancy.</description><identifier>ISSN: 1357-0560</identifier><identifier>EISSN: 1559-131X</identifier><identifier>DOI: 10.1007/s12032-014-0083-8</identifier><identifier>PMID: 24961466</identifier><identifier>CODEN: MONCEZ</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Breast cancer ; Breast Neoplasms - enzymology ; Breast Neoplasms - mortality ; Breast Neoplasms - pathology ; Case-Control Studies ; Cell Line, Tumor ; Female ; Gene Expression Regulation, Neoplastic ; Hematology ; Humans ; Internal Medicine ; Medicine ; Medicine & Public Health ; Middle Aged ; Oncology ; Original Paper ; Pathology ; Prognosis ; Protein-Serine-Threonine Kinases - genetics ; Protein-Serine-Threonine Kinases - metabolism ; Up-Regulation</subject><ispartof>Medical oncology (Northwood, London, England), 2014-08, Vol.31 (8), p.83-83, Article 83</ispartof><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-3d9da2b2bbd1c54371394e474eea941f26f0c1dbec6cac0d33b4ebf89cae98a53</citedby><cites>FETCH-LOGICAL-c372t-3d9da2b2bbd1c54371394e474eea941f26f0c1dbec6cac0d33b4ebf89cae98a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12032-014-0083-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12032-014-0083-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24961466$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Xing-hua</creatorcontrib><creatorcontrib>Song, Jun-wei</creatorcontrib><creatorcontrib>Liu, Jun-ling</creatorcontrib><creatorcontrib>Wu, Shu</creatorcontrib><creatorcontrib>Wang, Le-shi</creatorcontrib><creatorcontrib>Gong, Li-yun</creatorcontrib><creatorcontrib>Lin, Xi</creatorcontrib><title>Serine–arginine protein kinase 1 is associated with breast cancer progression and poor patient survival</title><title>Medical oncology (Northwood, London, England)</title><addtitle>Med Oncol</addtitle><addtitle>Med Oncol</addtitle><description>Breast cancer is the most common cancer and the second leading cause of mortality for women worldwide. It is necessary to identify valuable molecular markers to predict breast cancer progression in patients and treatment effect. Serine–arginine protein kinase 1 (SRPK1), a member of SR kinase family, phosphorylates the SR splicing factors which plays essential roles in normal cell development and multiple human diseases. In the current study, we wanted to explore if there are any relationships between SRPK1 expression in breast cancer and its clinical characteristics. The results showed that SRPK1 is upregulated in breast cancer cell lines and tissues at both mRNA and protein levels, measured by quantitative reverse transcriptase PCR and Western blotting. Immunohistochemical analysis showed a high expression of SRPK1 in 132 paraffin samples of patients with breast cancer; statistical analyses demonstrated that high expression of SRPK1 significantly correlated with clinical staging of patients with breast cancer (
P
< 0.001), TNM classification (
P
< 0.05). Low expression of SRPK1 leads to longer survival time, while high expression of SRPK1 leads to shorter survival time of patients. Multivariate analysis revealed that upregulation of SRPK1 might be an independent prognostic marker for the outcomes of patients with breast cancer. In conclusion, upregulation of SRPK1 might play an important role in the progression of breast cancer and might be considered as the potential diagnostic and therapeutic target to this malignancy.</description><subject>Adult</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - enzymology</subject><subject>Breast Neoplasms - mortality</subject><subject>Breast Neoplasms - pathology</subject><subject>Case-Control Studies</subject><subject>Cell Line, Tumor</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hematology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Pathology</subject><subject>Prognosis</subject><subject>Protein-Serine-Threonine Kinases - genetics</subject><subject>Protein-Serine-Threonine Kinases - metabolism</subject><subject>Up-Regulation</subject><issn>1357-0560</issn><issn>1559-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kctqFUEQhpug5P4A2UiDm2xGu_oyl6UEjYGACxXcNTU9NScdz-k5ds1E3PkOvqFPYh9OFBFcVVH9_X8V_QtxAeoFKNW8ZNDK6EqBrZRqTdUeiGNwrqvAwKcnpTeuqZSr1ZE4Yb5XSoPT3aE40rarwdb1sYjvKcdEP7__wLyKqbRym6eZYpKfY0ImCTKyROYpRJxpkF_jfCf7TMizDJgC5Z1ilYk5TkliGuR2msoQ50hplrzkh_iA6zPxdMQ10_ljPRUf37z-cPW2un13fXP16rYKptFzZYZuQN3rvh8gOGsaMJ0l21gi7CyMuh5VgKGnUAcMajCmt9SPbReQuhadORWXe99y1ZeFePabyIHWa0w0LezBWdWABtMU9Pk_6P205FSuK5RTtTWFLBTsqZAn5kyj3-a4wfzNg_K7HPw-B19y8LscfFs0zx6dl35Dwx_F748vgN4DXJ7SivJfq__r-gu3AZWb</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Li, Xing-hua</creator><creator>Song, Jun-wei</creator><creator>Liu, Jun-ling</creator><creator>Wu, Shu</creator><creator>Wang, Le-shi</creator><creator>Gong, Li-yun</creator><creator>Lin, Xi</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20140801</creationdate><title>Serine–arginine protein kinase 1 is associated with breast cancer progression and poor patient survival</title><author>Li, Xing-hua ; Song, Jun-wei ; Liu, Jun-ling ; Wu, Shu ; Wang, Le-shi ; Gong, Li-yun ; Lin, Xi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-3d9da2b2bbd1c54371394e474eea941f26f0c1dbec6cac0d33b4ebf89cae98a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - enzymology</topic><topic>Breast Neoplasms - mortality</topic><topic>Breast Neoplasms - pathology</topic><topic>Case-Control Studies</topic><topic>Cell Line, Tumor</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hematology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Pathology</topic><topic>Prognosis</topic><topic>Protein-Serine-Threonine Kinases - genetics</topic><topic>Protein-Serine-Threonine Kinases - metabolism</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Xing-hua</creatorcontrib><creatorcontrib>Song, Jun-wei</creatorcontrib><creatorcontrib>Liu, Jun-ling</creatorcontrib><creatorcontrib>Wu, Shu</creatorcontrib><creatorcontrib>Wang, Le-shi</creatorcontrib><creatorcontrib>Gong, Li-yun</creatorcontrib><creatorcontrib>Lin, Xi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Medical oncology (Northwood, London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Xing-hua</au><au>Song, Jun-wei</au><au>Liu, Jun-ling</au><au>Wu, Shu</au><au>Wang, Le-shi</au><au>Gong, Li-yun</au><au>Lin, Xi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serine–arginine protein kinase 1 is associated with breast cancer progression and poor patient survival</atitle><jtitle>Medical oncology (Northwood, London, England)</jtitle><stitle>Med Oncol</stitle><addtitle>Med Oncol</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>31</volume><issue>8</issue><spage>83</spage><epage>83</epage><pages>83-83</pages><artnum>83</artnum><issn>1357-0560</issn><eissn>1559-131X</eissn><coden>MONCEZ</coden><abstract>Breast cancer is the most common cancer and the second leading cause of mortality for women worldwide. It is necessary to identify valuable molecular markers to predict breast cancer progression in patients and treatment effect. Serine–arginine protein kinase 1 (SRPK1), a member of SR kinase family, phosphorylates the SR splicing factors which plays essential roles in normal cell development and multiple human diseases. In the current study, we wanted to explore if there are any relationships between SRPK1 expression in breast cancer and its clinical characteristics. The results showed that SRPK1 is upregulated in breast cancer cell lines and tissues at both mRNA and protein levels, measured by quantitative reverse transcriptase PCR and Western blotting. Immunohistochemical analysis showed a high expression of SRPK1 in 132 paraffin samples of patients with breast cancer; statistical analyses demonstrated that high expression of SRPK1 significantly correlated with clinical staging of patients with breast cancer (
P
< 0.001), TNM classification (
P
< 0.05). Low expression of SRPK1 leads to longer survival time, while high expression of SRPK1 leads to shorter survival time of patients. Multivariate analysis revealed that upregulation of SRPK1 might be an independent prognostic marker for the outcomes of patients with breast cancer. In conclusion, upregulation of SRPK1 might play an important role in the progression of breast cancer and might be considered as the potential diagnostic and therapeutic target to this malignancy.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24961466</pmid><doi>10.1007/s12032-014-0083-8</doi><tpages>1</tpages></addata></record> |
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| ispartof | Medical oncology (Northwood, London, England), 2014-08, Vol.31 (8), p.83-83, Article 83 |
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| subjects | Adult Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - mortality Breast Neoplasms - pathology Case-Control Studies Cell Line, Tumor Female Gene Expression Regulation, Neoplastic Hematology Humans Internal Medicine Medicine Medicine & Public Health Middle Aged Oncology Original Paper Pathology Prognosis Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Up-Regulation |
| title | Serine–arginine protein kinase 1 is associated with breast cancer progression and poor patient survival |
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