Central Norepinephrine Metabolism during Alcohol Intoxication in Addicts and Healthy Volunteers
The concentrations of the major norepinephrine metabolite, 3-methoxy-4-hydroxyphenylethylene glycol (MOPEG), in lumbar cerebrospinal fluid of alcoholic patients were markedly elevated during intoxication and successively declined during 1 and 3 weeks of abstinence. During intoxication the MOPEG conc...
Gespeichert in:
| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1981-09, Vol.213 (4512), p.1135-1137 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1137 |
|---|---|
| container_issue | 4512 |
| container_start_page | 1135 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 213 |
| creator | Borg, Stefan Kvande, Hans Sedvall, Göran |
| description | The concentrations of the major norepinephrine metabolite, 3-methoxy-4-hydroxyphenylethylene glycol (MOPEG), in lumbar cerebrospinal fluid of alcoholic patients were markedly elevated during intoxication and successively declined during 1 and 3 weeks of abstinence. During intoxication the MOPEG concentration in cerebrospinal fluid showed a statistically significant correlation with the blood alcohol concentration. In healthy volunteers who received 80 grams of ethanol, the MOPEG concentration in cerebrospinal fluid increased significantly. Healthy subjects sampled during intoxication had significantly higher concentrations of MOPEG in the cerebrospinal fluid than did subjects sampled after the end of intoxication. The results indicate that alcohol administration markedly stimulates norepinephrine metabolism in the central nervous system in human subjects, possibly by increasing unit impulse activity of central noradrenergic neurons. |
| doi_str_mv | 10.1126/science.7268421 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_15406529</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A2036919</galeid><jstor_id>1686666</jstor_id><sourcerecordid>A2036919</sourcerecordid><originalsourceid>FETCH-LOGICAL-c411t-26c19b915929f1cc1e7ae368af8cd71d5c97d2e2a6f8ff33b29745718979c4af3</originalsourceid><addsrcrecordid>eNpFkU1LAzEQhoMoWj_OXhRy8iJbk-xudnMsxS-oelGvIc3OtpE0qUkW9N8b6aJzmIF5nxleZhA6p2RKKeM3URtwGqYN423F6B6aUCLqQjBS7qMJISUvWtLUR-g4xg9CsibKQ3Q44hMk5-BSUBY_-wBb42C7DjnjJ0hq6a2JG9wNubPCM6v92lv86JL_Mlol4x02Ds-6zugUsXIdfgBl0_obv3s7uAQQ4ik66JWNcDbWE_R2d_s6fygWL_eP89mi0BWlqWBcU7EUtBZM9FRrCo2Ckreqb3XX0K7WoukYMMX7tu_LcslEU9UNbUUjdKX68gRd7fZug_8cICa5MVGDtcqBH6KkdUV4zUQGr3fgSlmQxmmfjX4l7a2FFchsav4iZ_l8XNBf-mZH6-BjDNDLbTAbFb4lJfL3AXJ8gBwvmicuRyPDcgPdH_-vX-z0j5h8-F_HW56j_AFvGIy5</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15406529</pqid></control><display><type>article</type><title>Central Norepinephrine Metabolism during Alcohol Intoxication in Addicts and Healthy Volunteers</title><source>American Association for the Advancement of Science</source><source>Jstor Complete Legacy</source><source>MEDLINE</source><creator>Borg, Stefan ; Kvande, Hans ; Sedvall, Göran</creator><creatorcontrib>Borg, Stefan ; Kvande, Hans ; Sedvall, Göran</creatorcontrib><description>The concentrations of the major norepinephrine metabolite, 3-methoxy-4-hydroxyphenylethylene glycol (MOPEG), in lumbar cerebrospinal fluid of alcoholic patients were markedly elevated during intoxication and successively declined during 1 and 3 weeks of abstinence. During intoxication the MOPEG concentration in cerebrospinal fluid showed a statistically significant correlation with the blood alcohol concentration. In healthy volunteers who received 80 grams of ethanol, the MOPEG concentration in cerebrospinal fluid increased significantly. Healthy subjects sampled during intoxication had significantly higher concentrations of MOPEG in the cerebrospinal fluid than did subjects sampled after the end of intoxication. The results indicate that alcohol administration markedly stimulates norepinephrine metabolism in the central nervous system in human subjects, possibly by increasing unit impulse activity of central noradrenergic neurons.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.7268421</identifier><identifier>PMID: 7268421</identifier><language>eng</language><publisher>United States: The American Association for the Advancement Science</publisher><subject>Adrenergic Fibers - metabolism ; Alcohol ; Alcohol in the body ; Alcoholic beverages ; Alcoholic intoxication ; Alcoholism ; Alcoholism - cerebrospinal fluid ; Alcoholism - metabolism ; Alcohols ; Animals ; Blood alcohol concentration ; Brain - metabolism ; Ethanol ; Ethanol - pharmacology ; Eyes ; Glycols - cerebrospinal fluid ; Humans ; Methoxyhydroxyphenylglycol - cerebrospinal fluid ; Norepinephrine ; Norepinephrine - metabolism ; Physiological aspects ; Substance Withdrawal Syndrome - cerebrospinal fluid ; Volunteerism</subject><ispartof>Science (American Association for the Advancement of Science), 1981-09, Vol.213 (4512), p.1135-1137</ispartof><rights>Copyright 1981 The American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-26c19b915929f1cc1e7ae368af8cd71d5c97d2e2a6f8ff33b29745718979c4af3</citedby><cites>FETCH-LOGICAL-c411t-26c19b915929f1cc1e7ae368af8cd71d5c97d2e2a6f8ff33b29745718979c4af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1686666$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1686666$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7268421$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Borg, Stefan</creatorcontrib><creatorcontrib>Kvande, Hans</creatorcontrib><creatorcontrib>Sedvall, Göran</creatorcontrib><title>Central Norepinephrine Metabolism during Alcohol Intoxication in Addicts and Healthy Volunteers</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The concentrations of the major norepinephrine metabolite, 3-methoxy-4-hydroxyphenylethylene glycol (MOPEG), in lumbar cerebrospinal fluid of alcoholic patients were markedly elevated during intoxication and successively declined during 1 and 3 weeks of abstinence. During intoxication the MOPEG concentration in cerebrospinal fluid showed a statistically significant correlation with the blood alcohol concentration. In healthy volunteers who received 80 grams of ethanol, the MOPEG concentration in cerebrospinal fluid increased significantly. Healthy subjects sampled during intoxication had significantly higher concentrations of MOPEG in the cerebrospinal fluid than did subjects sampled after the end of intoxication. The results indicate that alcohol administration markedly stimulates norepinephrine metabolism in the central nervous system in human subjects, possibly by increasing unit impulse activity of central noradrenergic neurons.</description><subject>Adrenergic Fibers - metabolism</subject><subject>Alcohol</subject><subject>Alcohol in the body</subject><subject>Alcoholic beverages</subject><subject>Alcoholic intoxication</subject><subject>Alcoholism</subject><subject>Alcoholism - cerebrospinal fluid</subject><subject>Alcoholism - metabolism</subject><subject>Alcohols</subject><subject>Animals</subject><subject>Blood alcohol concentration</subject><subject>Brain - metabolism</subject><subject>Ethanol</subject><subject>Ethanol - pharmacology</subject><subject>Eyes</subject><subject>Glycols - cerebrospinal fluid</subject><subject>Humans</subject><subject>Methoxyhydroxyphenylglycol - cerebrospinal fluid</subject><subject>Norepinephrine</subject><subject>Norepinephrine - metabolism</subject><subject>Physiological aspects</subject><subject>Substance Withdrawal Syndrome - cerebrospinal fluid</subject><subject>Volunteerism</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1LAzEQhoMoWj_OXhRy8iJbk-xudnMsxS-oelGvIc3OtpE0qUkW9N8b6aJzmIF5nxleZhA6p2RKKeM3URtwGqYN423F6B6aUCLqQjBS7qMJISUvWtLUR-g4xg9CsibKQ3Q44hMk5-BSUBY_-wBb42C7DjnjJ0hq6a2JG9wNubPCM6v92lv86JL_Mlol4x02Ds-6zugUsXIdfgBl0_obv3s7uAQQ4ik66JWNcDbWE_R2d_s6fygWL_eP89mi0BWlqWBcU7EUtBZM9FRrCo2Ckreqb3XX0K7WoukYMMX7tu_LcslEU9UNbUUjdKX68gRd7fZug_8cICa5MVGDtcqBH6KkdUV4zUQGr3fgSlmQxmmfjX4l7a2FFchsav4iZ_l8XNBf-mZH6-BjDNDLbTAbFb4lJfL3AXJ8gBwvmicuRyPDcgPdH_-vX-z0j5h8-F_HW56j_AFvGIy5</recordid><startdate>19810904</startdate><enddate>19810904</enddate><creator>Borg, Stefan</creator><creator>Kvande, Hans</creator><creator>Sedvall, Göran</creator><general>The American Association for the Advancement Science</general><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19810904</creationdate><title>Central Norepinephrine Metabolism during Alcohol Intoxication in Addicts and Healthy Volunteers</title><author>Borg, Stefan ; Kvande, Hans ; Sedvall, Göran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-26c19b915929f1cc1e7ae368af8cd71d5c97d2e2a6f8ff33b29745718979c4af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Adrenergic Fibers - metabolism</topic><topic>Alcohol</topic><topic>Alcohol in the body</topic><topic>Alcoholic beverages</topic><topic>Alcoholic intoxication</topic><topic>Alcoholism</topic><topic>Alcoholism - cerebrospinal fluid</topic><topic>Alcoholism - metabolism</topic><topic>Alcohols</topic><topic>Animals</topic><topic>Blood alcohol concentration</topic><topic>Brain - metabolism</topic><topic>Ethanol</topic><topic>Ethanol - pharmacology</topic><topic>Eyes</topic><topic>Glycols - cerebrospinal fluid</topic><topic>Humans</topic><topic>Methoxyhydroxyphenylglycol - cerebrospinal fluid</topic><topic>Norepinephrine</topic><topic>Norepinephrine - metabolism</topic><topic>Physiological aspects</topic><topic>Substance Withdrawal Syndrome - cerebrospinal fluid</topic><topic>Volunteerism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Borg, Stefan</creatorcontrib><creatorcontrib>Kvande, Hans</creatorcontrib><creatorcontrib>Sedvall, Göran</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Borg, Stefan</au><au>Kvande, Hans</au><au>Sedvall, Göran</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Central Norepinephrine Metabolism during Alcohol Intoxication in Addicts and Healthy Volunteers</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1981-09-04</date><risdate>1981</risdate><volume>213</volume><issue>4512</issue><spage>1135</spage><epage>1137</epage><pages>1135-1137</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>The concentrations of the major norepinephrine metabolite, 3-methoxy-4-hydroxyphenylethylene glycol (MOPEG), in lumbar cerebrospinal fluid of alcoholic patients were markedly elevated during intoxication and successively declined during 1 and 3 weeks of abstinence. During intoxication the MOPEG concentration in cerebrospinal fluid showed a statistically significant correlation with the blood alcohol concentration. In healthy volunteers who received 80 grams of ethanol, the MOPEG concentration in cerebrospinal fluid increased significantly. Healthy subjects sampled during intoxication had significantly higher concentrations of MOPEG in the cerebrospinal fluid than did subjects sampled after the end of intoxication. The results indicate that alcohol administration markedly stimulates norepinephrine metabolism in the central nervous system in human subjects, possibly by increasing unit impulse activity of central noradrenergic neurons.</abstract><cop>United States</cop><pub>The American Association for the Advancement Science</pub><pmid>7268421</pmid><doi>10.1126/science.7268421</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1981-09, Vol.213 (4512), p.1135-1137 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15406529 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Adrenergic Fibers - metabolism Alcohol Alcohol in the body Alcoholic beverages Alcoholic intoxication Alcoholism Alcoholism - cerebrospinal fluid Alcoholism - metabolism Alcohols Animals Blood alcohol concentration Brain - metabolism Ethanol Ethanol - pharmacology Eyes Glycols - cerebrospinal fluid Humans Methoxyhydroxyphenylglycol - cerebrospinal fluid Norepinephrine Norepinephrine - metabolism Physiological aspects Substance Withdrawal Syndrome - cerebrospinal fluid Volunteerism |
| title | Central Norepinephrine Metabolism during Alcohol Intoxication in Addicts and Healthy Volunteers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T18%3A54%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Central%20Norepinephrine%20Metabolism%20during%20Alcohol%20Intoxication%20in%20Addicts%20and%20Healthy%20Volunteers&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Borg,%20Stefan&rft.date=1981-09-04&rft.volume=213&rft.issue=4512&rft.spage=1135&rft.epage=1137&rft.pages=1135-1137&rft.issn=0036-8075&rft.eissn=1095-9203&rft_id=info:doi/10.1126/science.7268421&rft_dat=%3Cgale_proqu%3EA2036919%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15406529&rft_id=info:pmid/7268421&rft_galeid=A2036919&rft_jstor_id=1686666&rfr_iscdi=true |