Role of Ca super(++) in Stimulus-Secretion Coupling in the Gastric Oxyntic Cell: Effect of A23187

Role of Ca super(++) in Stimulus-Secretion Coupling in the Gastric Oxyntic Cell: Effect of A23187

The effects of Ca super(++) ionophore A23187 on H super(+) secretion and histamine release were studied in the isolated gastric mucosa of the toad Bufo marinus). A23187 added from the mucosal side stimulated H super(+) secretion. At high concentrations, A23187 also caused histamine release. This his...

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Veröffentlicht in:Cell calcium (Edinburgh) 1981-01, Vol.2 (6), p.573-585
Hauptverfasser: Michelangeli, F, Jiron, C, Ruiz, M C
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creator Michelangeli, F
Jiron, C
Ruiz, M C
description The effects of Ca super(++) ionophore A23187 on H super(+) secretion and histamine release were studied in the isolated gastric mucosa of the toad Bufo marinus). A23187 added from the mucosal side stimulated H super(+) secretion. At high concentrations, A23187 also caused histamine release. This histamine was not sufficient to explain the effects of A23187 on H super(+) secretion. Metiamide, only partially inhibited the effect of ionophore. There was summation and/or potentiation of effects between A23187 and histamine. The results are consistent with the hypothesis that Ca super(++) acts as a second messenger in stimulus-secretion coupling in the oxyntic cell. It is possible that Ca super(++) and cAMP may interact as parallel second messengers in the control of gastric H super(+) secretion.
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title Role of Ca super(++) in Stimulus-Secretion Coupling in the Gastric Oxyntic Cell: Effect of A23187
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