Reduced risk of Parkinson's disease associated with lower body mass index and heavy leisure-time physical activity
The risk factors for Parkinson's disease (PD) are not well established. We therefore examined the prediction of various lifestyle factors on the incidence of PD in a cohort drawn from the Finnish Mobile Clinic Health Examination Survey, conducted in 1973-1976. The study population comprised 6,7...
Gespeichert in:
| Veröffentlicht in: | European journal of epidemiology 2014-04, Vol.29 (4), p.285-292 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 292 |
|---|---|
| container_issue | 4 |
| container_start_page | 285 |
| container_title | European journal of epidemiology |
| container_volume | 29 |
| creator | Sääksjärvi, Katri Knekt, Paul Männistö, Satu Lyytinen, Jukka Jääskeläinen, Tuija Kanerva, Noora Heliövaara, Markku |
| description | The risk factors for Parkinson's disease (PD) are not well established. We therefore examined the prediction of various lifestyle factors on the incidence of PD in a cohort drawn from the Finnish Mobile Clinic Health Examination Survey, conducted in 1973-1976. The study population comprised 6,715 men and women aged 50-79 years and free of PD at the baseline. All of the subjects completed a baseline health examination (including height and weight measurements) and a questionnaire providing information on leisure-time physical activity, smoking, and alcohol consumption. During a 22-year follow-up, 101 incident cases of PD occurred. The statistical analyses were based on Cox's model including age, sex, education, community density, occupation, coffee consumption, body mass index (BMI), leisure-time physical activity, smoking and alcohol consumption as independent variables. At first, BMI was not associated with PD risk, but after exclusion of the first 15 years of follow-up, an elevated risk appeared at higher BMI levels (P for trend 0.02). Furthermore, subjects with heavy leisure-time physical activity had a lower PD risk than those with no activity [relative risk (RR) 0.27, 95 % confidence interval (CI) 0.08-0.90]. In variance with findings for other chronic diseases, current smokers had a lower PD risk than those who had never smoked (RR 0.23, 95 % CI 0.08-0.67), and individuals with moderate alcohol intake (at the level of |
| doi_str_mv | 10.1007/s10654-014-9887-2 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1540235583</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>43774968</jstor_id><sourcerecordid>43774968</sourcerecordid><originalsourceid>FETCH-LOGICAL-c527t-98ff2551d34d0ee2d882ec0e1ed640502fa103b4eb02f8fb74d1c896db63fb0e3</originalsourceid><addsrcrecordid>eNqNkd2L1DAUxYMo7jj6B_igBET0pZrPNn1cFr9gQRF9Lmly62S204y57a79703puIoP4lMC93dOcu4h5DFnrzhj1WvkrNSqYFwVtTFVIe6QDdeVLCph1F2yYbKWhahrdkYeIO4ZY4bV-j45E6qUsjR8Q9Jn8JMDT1PAKxo7-smmqzBgHF4g9QHBIlCLGF2wY8ZuwrijfbyBRNvoZ3rIMxoGDz-oHTzdgb2eaQ8BpwTFGA5Aj7sZg7M9tW4M12GcH5J7ne0RHp3OLfn69s2Xi_fF5cd3Hy7OLwunRTXmRF0ntOZeKs8AhDdGgGPAwZeKaSY6y5lsFbT5arq2Up47U5e-LWXXMpBb8nL1Pab4fQIcm0NAB31vB4gTNlwrJqTWRv4HKmqj5LK2LXn2F7qPUxpykIUyhleq5pniK-VSREzQNccUDjbNDWfN0l2zdtfk7pqlu0ZkzdOT89QewN8qfpWVgecnwGJeaJfs4AL-5oyuy1IvnFg5zKPhG6Q_vviP15-soj2OMd2aKlnlQKWRPwEwLLtD</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1528817491</pqid></control><display><type>article</type><title>Reduced risk of Parkinson's disease associated with lower body mass index and heavy leisure-time physical activity</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>SpringerLink Journals - AutoHoldings</source><creator>Sääksjärvi, Katri ; Knekt, Paul ; Männistö, Satu ; Lyytinen, Jukka ; Jääskeläinen, Tuija ; Kanerva, Noora ; Heliövaara, Markku</creator><creatorcontrib>Sääksjärvi, Katri ; Knekt, Paul ; Männistö, Satu ; Lyytinen, Jukka ; Jääskeläinen, Tuija ; Kanerva, Noora ; Heliövaara, Markku</creatorcontrib><description>The risk factors for Parkinson's disease (PD) are not well established. We therefore examined the prediction of various lifestyle factors on the incidence of PD in a cohort drawn from the Finnish Mobile Clinic Health Examination Survey, conducted in 1973-1976. The study population comprised 6,715 men and women aged 50-79 years and free of PD at the baseline. All of the subjects completed a baseline health examination (including height and weight measurements) and a questionnaire providing information on leisure-time physical activity, smoking, and alcohol consumption. During a 22-year follow-up, 101 incident cases of PD occurred. The statistical analyses were based on Cox's model including age, sex, education, community density, occupation, coffee consumption, body mass index (BMI), leisure-time physical activity, smoking and alcohol consumption as independent variables. At first, BMI was not associated with PD risk, but after exclusion of the first 15 years of follow-up, an elevated risk appeared at higher BMI levels (P for trend 0.02). Furthermore, subjects with heavy leisure-time physical activity had a lower PD risk than those with no activity [relative risk (RR) 0.27, 95 % confidence interval (CI) 0.08-0.90]. In variance with findings for other chronic diseases, current smokers had a lower PD risk than those who had never smoked (RR 0.23, 95 % CI 0.08-0.67), and individuals with moderate alcohol intake (at the level of <5 g/day) had an elevated PD risk compared to nondrinkers. The results support the hypothesis that lifestyle factors predict the occurrence of Parkinson's disease, but more research is needed.</description><identifier>ISSN: 0393-2990</identifier><identifier>EISSN: 1573-7284</identifier><identifier>DOI: 10.1007/s10654-014-9887-2</identifier><identifier>PMID: 24633681</identifier><identifier>CODEN: EJEPE8</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Aged ; Alcohol drinking ; Alcohol Drinking - epidemiology ; Alcohol use ; Alcoholic beverages ; Alcohols ; Biological and medical sciences ; Body Mass Index ; Cardiology ; Cigar smoking ; Cigarette smoking ; Coffee ; Cohort studies ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Disease risk ; Epidemiology ; Exercise ; Female ; Finland - epidemiology ; Follow-Up Studies ; General aspects ; Health Surveys ; Humans ; Incidence ; Infectious Diseases ; Leisure Activities ; Life Style ; Lifestyles ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Miscellaneous ; NEUROEPIDEMIOLOGY ; Neurology ; Obesity - epidemiology ; Oncology ; Parkinson disease ; Parkinson Disease - epidemiology ; Parkinson Disease - etiology ; Parkinson's disease ; Population Surveillance ; Prospective Studies ; Public Health ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors ; Risk Reduction Behavior ; Sex Factors ; Smoking ; Smoking - epidemiology ; Statistical analysis ; Surveys and Questionnaires ; Tobacco, tobacco smoking ; Toxicology</subject><ispartof>European journal of epidemiology, 2014-04, Vol.29 (4), p.285-292</ispartof><rights>Springer Science+Business Media 2014</rights><rights>Springer Science+Business Media Dordrecht 2014</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-98ff2551d34d0ee2d882ec0e1ed640502fa103b4eb02f8fb74d1c896db63fb0e3</citedby><cites>FETCH-LOGICAL-c527t-98ff2551d34d0ee2d882ec0e1ed640502fa103b4eb02f8fb74d1c896db63fb0e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/43774968$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/43774968$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27923,27924,41487,42556,51318,58016,58249</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28596651$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24633681$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sääksjärvi, Katri</creatorcontrib><creatorcontrib>Knekt, Paul</creatorcontrib><creatorcontrib>Männistö, Satu</creatorcontrib><creatorcontrib>Lyytinen, Jukka</creatorcontrib><creatorcontrib>Jääskeläinen, Tuija</creatorcontrib><creatorcontrib>Kanerva, Noora</creatorcontrib><creatorcontrib>Heliövaara, Markku</creatorcontrib><title>Reduced risk of Parkinson's disease associated with lower body mass index and heavy leisure-time physical activity</title><title>European journal of epidemiology</title><addtitle>Eur J Epidemiol</addtitle><addtitle>Eur J Epidemiol</addtitle><description>The risk factors for Parkinson's disease (PD) are not well established. We therefore examined the prediction of various lifestyle factors on the incidence of PD in a cohort drawn from the Finnish Mobile Clinic Health Examination Survey, conducted in 1973-1976. The study population comprised 6,715 men and women aged 50-79 years and free of PD at the baseline. All of the subjects completed a baseline health examination (including height and weight measurements) and a questionnaire providing information on leisure-time physical activity, smoking, and alcohol consumption. During a 22-year follow-up, 101 incident cases of PD occurred. The statistical analyses were based on Cox's model including age, sex, education, community density, occupation, coffee consumption, body mass index (BMI), leisure-time physical activity, smoking and alcohol consumption as independent variables. At first, BMI was not associated with PD risk, but after exclusion of the first 15 years of follow-up, an elevated risk appeared at higher BMI levels (P for trend 0.02). Furthermore, subjects with heavy leisure-time physical activity had a lower PD risk than those with no activity [relative risk (RR) 0.27, 95 % confidence interval (CI) 0.08-0.90]. In variance with findings for other chronic diseases, current smokers had a lower PD risk than those who had never smoked (RR 0.23, 95 % CI 0.08-0.67), and individuals with moderate alcohol intake (at the level of <5 g/day) had an elevated PD risk compared to nondrinkers. The results support the hypothesis that lifestyle factors predict the occurrence of Parkinson's disease, but more research is needed.</description><subject>Aged</subject><subject>Alcohol drinking</subject><subject>Alcohol Drinking - epidemiology</subject><subject>Alcohol use</subject><subject>Alcoholic beverages</subject><subject>Alcohols</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Cardiology</subject><subject>Cigar smoking</subject><subject>Cigarette smoking</subject><subject>Coffee</subject><subject>Cohort studies</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Disease risk</subject><subject>Epidemiology</subject><subject>Exercise</subject><subject>Female</subject><subject>Finland - epidemiology</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Health Surveys</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infectious Diseases</subject><subject>Leisure Activities</subject><subject>Life Style</subject><subject>Lifestyles</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>NEUROEPIDEMIOLOGY</subject><subject>Neurology</subject><subject>Obesity - epidemiology</subject><subject>Oncology</subject><subject>Parkinson disease</subject><subject>Parkinson Disease - epidemiology</subject><subject>Parkinson Disease - etiology</subject><subject>Parkinson's disease</subject><subject>Population Surveillance</subject><subject>Prospective Studies</subject><subject>Public Health</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk Factors</subject><subject>Risk Reduction Behavior</subject><subject>Sex Factors</subject><subject>Smoking</subject><subject>Smoking - epidemiology</subject><subject>Statistical analysis</subject><subject>Surveys and Questionnaires</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><issn>0393-2990</issn><issn>1573-7284</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkd2L1DAUxYMo7jj6B_igBET0pZrPNn1cFr9gQRF9Lmly62S204y57a79703puIoP4lMC93dOcu4h5DFnrzhj1WvkrNSqYFwVtTFVIe6QDdeVLCph1F2yYbKWhahrdkYeIO4ZY4bV-j45E6qUsjR8Q9Jn8JMDT1PAKxo7-smmqzBgHF4g9QHBIlCLGF2wY8ZuwrijfbyBRNvoZ3rIMxoGDz-oHTzdgb2eaQ8BpwTFGA5Aj7sZg7M9tW4M12GcH5J7ne0RHp3OLfn69s2Xi_fF5cd3Hy7OLwunRTXmRF0ntOZeKs8AhDdGgGPAwZeKaSY6y5lsFbT5arq2Up47U5e-LWXXMpBb8nL1Pab4fQIcm0NAB31vB4gTNlwrJqTWRv4HKmqj5LK2LXn2F7qPUxpykIUyhleq5pniK-VSREzQNccUDjbNDWfN0l2zdtfk7pqlu0ZkzdOT89QewN8qfpWVgecnwGJeaJfs4AL-5oyuy1IvnFg5zKPhG6Q_vviP15-soj2OMd2aKlnlQKWRPwEwLLtD</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Sääksjärvi, Katri</creator><creator>Knekt, Paul</creator><creator>Männistö, Satu</creator><creator>Lyytinen, Jukka</creator><creator>Jääskeläinen, Tuija</creator><creator>Kanerva, Noora</creator><creator>Heliövaara, Markku</creator><general>Springer</general><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7U1</scope><scope>7U2</scope></search><sort><creationdate>20140401</creationdate><title>Reduced risk of Parkinson's disease associated with lower body mass index and heavy leisure-time physical activity</title><author>Sääksjärvi, Katri ; Knekt, Paul ; Männistö, Satu ; Lyytinen, Jukka ; Jääskeläinen, Tuija ; Kanerva, Noora ; Heliövaara, Markku</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-98ff2551d34d0ee2d882ec0e1ed640502fa103b4eb02f8fb74d1c896db63fb0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Alcohol drinking</topic><topic>Alcohol Drinking - epidemiology</topic><topic>Alcohol use</topic><topic>Alcoholic beverages</topic><topic>Alcohols</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Cardiology</topic><topic>Cigar smoking</topic><topic>Cigarette smoking</topic><topic>Coffee</topic><topic>Cohort studies</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Disease risk</topic><topic>Epidemiology</topic><topic>Exercise</topic><topic>Female</topic><topic>Finland - epidemiology</topic><topic>Follow-Up Studies</topic><topic>General aspects</topic><topic>Health Surveys</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infectious Diseases</topic><topic>Leisure Activities</topic><topic>Life Style</topic><topic>Lifestyles</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>NEUROEPIDEMIOLOGY</topic><topic>Neurology</topic><topic>Obesity - epidemiology</topic><topic>Oncology</topic><topic>Parkinson disease</topic><topic>Parkinson Disease - epidemiology</topic><topic>Parkinson Disease - etiology</topic><topic>Parkinson's disease</topic><topic>Population Surveillance</topic><topic>Prospective Studies</topic><topic>Public Health</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk Factors</topic><topic>Risk Reduction Behavior</topic><topic>Sex Factors</topic><topic>Smoking</topic><topic>Smoking - epidemiology</topic><topic>Statistical analysis</topic><topic>Surveys and Questionnaires</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sääksjärvi, Katri</creatorcontrib><creatorcontrib>Knekt, Paul</creatorcontrib><creatorcontrib>Männistö, Satu</creatorcontrib><creatorcontrib>Lyytinen, Jukka</creatorcontrib><creatorcontrib>Jääskeläinen, Tuija</creatorcontrib><creatorcontrib>Kanerva, Noora</creatorcontrib><creatorcontrib>Heliövaara, Markku</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><jtitle>European journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sääksjärvi, Katri</au><au>Knekt, Paul</au><au>Männistö, Satu</au><au>Lyytinen, Jukka</au><au>Jääskeläinen, Tuija</au><au>Kanerva, Noora</au><au>Heliövaara, Markku</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced risk of Parkinson's disease associated with lower body mass index and heavy leisure-time physical activity</atitle><jtitle>European journal of epidemiology</jtitle><stitle>Eur J Epidemiol</stitle><addtitle>Eur J Epidemiol</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>29</volume><issue>4</issue><spage>285</spage><epage>292</epage><pages>285-292</pages><issn>0393-2990</issn><eissn>1573-7284</eissn><coden>EJEPE8</coden><abstract>The risk factors for Parkinson's disease (PD) are not well established. We therefore examined the prediction of various lifestyle factors on the incidence of PD in a cohort drawn from the Finnish Mobile Clinic Health Examination Survey, conducted in 1973-1976. The study population comprised 6,715 men and women aged 50-79 years and free of PD at the baseline. All of the subjects completed a baseline health examination (including height and weight measurements) and a questionnaire providing information on leisure-time physical activity, smoking, and alcohol consumption. During a 22-year follow-up, 101 incident cases of PD occurred. The statistical analyses were based on Cox's model including age, sex, education, community density, occupation, coffee consumption, body mass index (BMI), leisure-time physical activity, smoking and alcohol consumption as independent variables. At first, BMI was not associated with PD risk, but after exclusion of the first 15 years of follow-up, an elevated risk appeared at higher BMI levels (P for trend 0.02). Furthermore, subjects with heavy leisure-time physical activity had a lower PD risk than those with no activity [relative risk (RR) 0.27, 95 % confidence interval (CI) 0.08-0.90]. In variance with findings for other chronic diseases, current smokers had a lower PD risk than those who had never smoked (RR 0.23, 95 % CI 0.08-0.67), and individuals with moderate alcohol intake (at the level of <5 g/day) had an elevated PD risk compared to nondrinkers. The results support the hypothesis that lifestyle factors predict the occurrence of Parkinson's disease, but more research is needed.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>24633681</pmid><doi>10.1007/s10654-014-9887-2</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0393-2990 |
| ispartof | European journal of epidemiology, 2014-04, Vol.29 (4), p.285-292 |
| issn | 0393-2990 1573-7284 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1540235583 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; SpringerLink Journals - AutoHoldings |
| subjects | Aged Alcohol drinking Alcohol Drinking - epidemiology Alcohol use Alcoholic beverages Alcohols Biological and medical sciences Body Mass Index Cardiology Cigar smoking Cigarette smoking Coffee Cohort studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease risk Epidemiology Exercise Female Finland - epidemiology Follow-Up Studies General aspects Health Surveys Humans Incidence Infectious Diseases Leisure Activities Life Style Lifestyles Male Medical sciences Medicine Medicine & Public Health Middle Aged Miscellaneous NEUROEPIDEMIOLOGY Neurology Obesity - epidemiology Oncology Parkinson disease Parkinson Disease - epidemiology Parkinson Disease - etiology Parkinson's disease Population Surveillance Prospective Studies Public Health Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors Risk Reduction Behavior Sex Factors Smoking Smoking - epidemiology Statistical analysis Surveys and Questionnaires Tobacco, tobacco smoking Toxicology |
| title | Reduced risk of Parkinson's disease associated with lower body mass index and heavy leisure-time physical activity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T18%3A14%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Reduced%20risk%20of%20Parkinson's%20disease%20associated%20with%20lower%20body%20mass%20index%20and%20heavy%20leisure-time%20physical%20activity&rft.jtitle=European%20journal%20of%20epidemiology&rft.au=S%C3%A4%C3%A4ksj%C3%A4rvi,%20Katri&rft.date=2014-04-01&rft.volume=29&rft.issue=4&rft.spage=285&rft.epage=292&rft.pages=285-292&rft.issn=0393-2990&rft.eissn=1573-7284&rft.coden=EJEPE8&rft_id=info:doi/10.1007/s10654-014-9887-2&rft_dat=%3Cjstor_proqu%3E43774968%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1528817491&rft_id=info:pmid/24633681&rft_jstor_id=43774968&rfr_iscdi=true |