Development of a novel calcium phosphate cement composed mainly of calcium sodium phosphate with high osteoconductivity
Two novel calcium phosphate cements (CPC) have been developed using calcium sodium phosphate (CSP) as the main ingredient. The first of these cements, labeled CAC, contained CSP, α-tricalcium phosphate (TCP), and anhydrous citric acid, whereas the second, labeled CABC, contained CSP, α-TCP, β-TCP, a...
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| Veröffentlicht in: | Journal of materials science. Materials in medicine 2014-06, Vol.25 (6), p.1505-1517 |
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| creator | Tanaka, Masashi Takemoto, Mitsuru Fujibayashi, Shunsuke Kawai, Toshiyuki Tsukanaka, Masako Takami, Kimiaki Motojima, Satoshi Inoue, Hikaru Nakamura, Takashi Matsuda, Shuichi |
| description | Two novel calcium phosphate cements (CPC) have been developed using calcium sodium phosphate (CSP) as the main ingredient. The first of these cements, labeled CAC, contained CSP, α-tricalcium phosphate (TCP), and anhydrous citric acid, whereas the second, labeled CABC, contained CSP, α-TCP, β-TCP, and anhydrous citric acid. Biopex
®
-R (PENTAX, Tokyo, Japan), which is a commercially available CPC (Com-CPC), and OSferion
®
(Olympus Terumo Biomaterials Corp., Tokyo, Japan), which is a commercially available porous β-TCP, were used as reference controls for analysis. In vitro analysis showed that CABC set in 5.7 ± 0.3 min at 22 °C and had a compressive strength of 86.0 ± 9.7 MPa after 5 days. Furthermore, this material had a compressive strength of 26.7 ± 3.7 MPa after 2 h in physiologic saline. CAC showed a statistically significantly lower compressive strength in the presence of physiologic saline and statistically significantly longer setting times than those of CABC. CABC and CAC exhibited apatite-forming abilities in simulated body fluid that were faster than that of Com-CPC. Samples of the materials were implanted into the femoral condyles of rabbits for in vivo analysis, and subsequent histological examinations revealed that CABC exhibited superior osteoconductivity and equivalent bioresorbability compared with Com-CPC, as well as superior osteoconductivity and bioresorbability compared with CAC. CABC could therefore be used as an alternative bone substitute material. |
| doi_str_mv | 10.1007/s10856-014-5181-9 |
| format | Article |
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®
-R (PENTAX, Tokyo, Japan), which is a commercially available CPC (Com-CPC), and OSferion
®
(Olympus Terumo Biomaterials Corp., Tokyo, Japan), which is a commercially available porous β-TCP, were used as reference controls for analysis. In vitro analysis showed that CABC set in 5.7 ± 0.3 min at 22 °C and had a compressive strength of 86.0 ± 9.7 MPa after 5 days. Furthermore, this material had a compressive strength of 26.7 ± 3.7 MPa after 2 h in physiologic saline. CAC showed a statistically significantly lower compressive strength in the presence of physiologic saline and statistically significantly longer setting times than those of CABC. CABC and CAC exhibited apatite-forming abilities in simulated body fluid that were faster than that of Com-CPC. Samples of the materials were implanted into the femoral condyles of rabbits for in vivo analysis, and subsequent histological examinations revealed that CABC exhibited superior osteoconductivity and equivalent bioresorbability compared with Com-CPC, as well as superior osteoconductivity and bioresorbability compared with CAC. CABC could therefore be used as an alternative bone substitute material.</description><identifier>ISSN: 0957-4530</identifier><identifier>EISSN: 1573-4838</identifier><identifier>DOI: 10.1007/s10856-014-5181-9</identifier><identifier>PMID: 24671331</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Absorption ; Animals ; Biological and medical sciences ; Biomaterials ; Biomedical Engineering and Bioengineering ; Biomedical materials ; Body Fluids - chemistry ; Bone Cements - chemical synthesis ; Bone Cements - therapeutic use ; Bone Regeneration - drug effects ; Bone Regeneration - physiology ; Calcium phosphates ; Calcium Phosphates - administration & dosage ; Calcium Phosphates - chemical synthesis ; Cement ; Ceramics ; Chemistry and Materials Science ; Composites ; Compressive Strength ; Femoral Fractures - pathology ; Femoral Fractures - therapy ; Glass ; Hardness ; Male ; Materials Science ; Materials Testing ; Medical sciences ; Natural Materials ; Orthopedic surgery ; Polymer Sciences ; Rabbits ; Regenerative Medicine/Tissue Engineering ; Surface Properties ; Surfaces and Interfaces ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology. Biomaterials. Equipments ; Thin Films ; Treatment Outcome</subject><ispartof>Journal of materials science. Materials in medicine, 2014-06, Vol.25 (6), p.1505-1517</ispartof><rights>Springer Science+Business Media New York 2014</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-69d60b0b8028324a0d216cdc27e86d482fd738f4d39320fcc0a0a91cabbca57c3</citedby><cites>FETCH-LOGICAL-c542t-69d60b0b8028324a0d216cdc27e86d482fd738f4d39320fcc0a0a91cabbca57c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10856-014-5181-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10856-014-5181-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28565340$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24671331$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanaka, Masashi</creatorcontrib><creatorcontrib>Takemoto, Mitsuru</creatorcontrib><creatorcontrib>Fujibayashi, Shunsuke</creatorcontrib><creatorcontrib>Kawai, Toshiyuki</creatorcontrib><creatorcontrib>Tsukanaka, Masako</creatorcontrib><creatorcontrib>Takami, Kimiaki</creatorcontrib><creatorcontrib>Motojima, Satoshi</creatorcontrib><creatorcontrib>Inoue, Hikaru</creatorcontrib><creatorcontrib>Nakamura, Takashi</creatorcontrib><creatorcontrib>Matsuda, Shuichi</creatorcontrib><title>Development of a novel calcium phosphate cement composed mainly of calcium sodium phosphate with high osteoconductivity</title><title>Journal of materials science. Materials in medicine</title><addtitle>J Mater Sci: Mater Med</addtitle><addtitle>J Mater Sci Mater Med</addtitle><description>Two novel calcium phosphate cements (CPC) have been developed using calcium sodium phosphate (CSP) as the main ingredient. The first of these cements, labeled CAC, contained CSP, α-tricalcium phosphate (TCP), and anhydrous citric acid, whereas the second, labeled CABC, contained CSP, α-TCP, β-TCP, and anhydrous citric acid. Biopex
®
-R (PENTAX, Tokyo, Japan), which is a commercially available CPC (Com-CPC), and OSferion
®
(Olympus Terumo Biomaterials Corp., Tokyo, Japan), which is a commercially available porous β-TCP, were used as reference controls for analysis. In vitro analysis showed that CABC set in 5.7 ± 0.3 min at 22 °C and had a compressive strength of 86.0 ± 9.7 MPa after 5 days. Furthermore, this material had a compressive strength of 26.7 ± 3.7 MPa after 2 h in physiologic saline. CAC showed a statistically significantly lower compressive strength in the presence of physiologic saline and statistically significantly longer setting times than those of CABC. CABC and CAC exhibited apatite-forming abilities in simulated body fluid that were faster than that of Com-CPC. Samples of the materials were implanted into the femoral condyles of rabbits for in vivo analysis, and subsequent histological examinations revealed that CABC exhibited superior osteoconductivity and equivalent bioresorbability compared with Com-CPC, as well as superior osteoconductivity and bioresorbability compared with CAC. CABC could therefore be used as an alternative bone substitute material.</description><subject>Absorption</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomaterials</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedical materials</subject><subject>Body Fluids - chemistry</subject><subject>Bone Cements - chemical synthesis</subject><subject>Bone Cements - therapeutic use</subject><subject>Bone Regeneration - drug effects</subject><subject>Bone Regeneration - physiology</subject><subject>Calcium phosphates</subject><subject>Calcium Phosphates - administration & dosage</subject><subject>Calcium Phosphates - chemical synthesis</subject><subject>Cement</subject><subject>Ceramics</subject><subject>Chemistry and Materials Science</subject><subject>Composites</subject><subject>Compressive Strength</subject><subject>Femoral Fractures - pathology</subject><subject>Femoral Fractures - therapy</subject><subject>Glass</subject><subject>Hardness</subject><subject>Male</subject><subject>Materials Science</subject><subject>Materials Testing</subject><subject>Medical sciences</subject><subject>Natural Materials</subject><subject>Orthopedic surgery</subject><subject>Polymer Sciences</subject><subject>Rabbits</subject><subject>Regenerative Medicine/Tissue Engineering</subject><subject>Surface Properties</subject><subject>Surfaces and Interfaces</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology. Biomaterials. 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Materials in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanaka, Masashi</au><au>Takemoto, Mitsuru</au><au>Fujibayashi, Shunsuke</au><au>Kawai, Toshiyuki</au><au>Tsukanaka, Masako</au><au>Takami, Kimiaki</au><au>Motojima, Satoshi</au><au>Inoue, Hikaru</au><au>Nakamura, Takashi</au><au>Matsuda, Shuichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of a novel calcium phosphate cement composed mainly of calcium sodium phosphate with high osteoconductivity</atitle><jtitle>Journal of materials science. Materials in medicine</jtitle><stitle>J Mater Sci: Mater Med</stitle><addtitle>J Mater Sci Mater Med</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>25</volume><issue>6</issue><spage>1505</spage><epage>1517</epage><pages>1505-1517</pages><issn>0957-4530</issn><eissn>1573-4838</eissn><abstract>Two novel calcium phosphate cements (CPC) have been developed using calcium sodium phosphate (CSP) as the main ingredient. The first of these cements, labeled CAC, contained CSP, α-tricalcium phosphate (TCP), and anhydrous citric acid, whereas the second, labeled CABC, contained CSP, α-TCP, β-TCP, and anhydrous citric acid. Biopex
®
-R (PENTAX, Tokyo, Japan), which is a commercially available CPC (Com-CPC), and OSferion
®
(Olympus Terumo Biomaterials Corp., Tokyo, Japan), which is a commercially available porous β-TCP, were used as reference controls for analysis. In vitro analysis showed that CABC set in 5.7 ± 0.3 min at 22 °C and had a compressive strength of 86.0 ± 9.7 MPa after 5 days. Furthermore, this material had a compressive strength of 26.7 ± 3.7 MPa after 2 h in physiologic saline. CAC showed a statistically significantly lower compressive strength in the presence of physiologic saline and statistically significantly longer setting times than those of CABC. CABC and CAC exhibited apatite-forming abilities in simulated body fluid that were faster than that of Com-CPC. Samples of the materials were implanted into the femoral condyles of rabbits for in vivo analysis, and subsequent histological examinations revealed that CABC exhibited superior osteoconductivity and equivalent bioresorbability compared with Com-CPC, as well as superior osteoconductivity and bioresorbability compared with CAC. CABC could therefore be used as an alternative bone substitute material.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24671331</pmid><doi>10.1007/s10856-014-5181-9</doi><tpages>13</tpages></addata></record> |
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| ispartof | Journal of materials science. Materials in medicine, 2014-06, Vol.25 (6), p.1505-1517 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Absorption Animals Biological and medical sciences Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Body Fluids - chemistry Bone Cements - chemical synthesis Bone Cements - therapeutic use Bone Regeneration - drug effects Bone Regeneration - physiology Calcium phosphates Calcium Phosphates - administration & dosage Calcium Phosphates - chemical synthesis Cement Ceramics Chemistry and Materials Science Composites Compressive Strength Femoral Fractures - pathology Femoral Fractures - therapy Glass Hardness Male Materials Science Materials Testing Medical sciences Natural Materials Orthopedic surgery Polymer Sciences Rabbits Regenerative Medicine/Tissue Engineering Surface Properties Surfaces and Interfaces Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Thin Films Treatment Outcome |
| title | Development of a novel calcium phosphate cement composed mainly of calcium sodium phosphate with high osteoconductivity |
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