Developmental rates of immatures of three Chrysomya species (Diptera: Calliphoridae) under the effect of methylphenidate hydrochloride, phenobarbital, and methylphenidate hydrochloride associated with phenobarbital
Entomotoxicology is focused on obtaining data on necrophagous entomofauna, for criminal investigations purposes. This study aimed to evaluate the effect of different concentrations of methylphenidate hydrochloride, phenobarbital, and their association on the developmental rate, larval and pupal surv...
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| Veröffentlicht in: | Parasitology research (1987) 2014-05, Vol.113 (5), p.1897-1907 |
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| container_title | Parasitology research (1987) |
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| creator | Rezende, Fábio Alonso, Marcela A Souza, Carina M Thyssen, Patrícia J Linhares, Arício X |
| description | Entomotoxicology is focused on obtaining data on necrophagous entomofauna, for criminal investigations purposes. This study aimed to evaluate the effect of different concentrations of methylphenidate hydrochloride, phenobarbital, and their association on the developmental rate, larval and pupal survivorship, and the interval of emergence of adults of Chrysomya albiceps (Wiedemann), Chrysomya megacephala (Fabricius), and Chrysomya putoria (Wiedemann) (Diptera: Calliphoridae). Considering the therapeutic dose (TD) of methylphenidate hydrochloride (0.29 mg/Kg), the concentrations tested were 10× TD, 50× TD, and 100× TD. For phenobarbital, the concentrations used were 1× TD (=150 mg/Kg), 3.3× TD, and 6.7× TD. For the association of the drugs, the combinations used were 10× TD–methylphenidate hydrochloride plus 1× TD–phenobarbital, 50× TD–methylphenidate hydrochloride plus 3.3× TD–phenobarbital, and 100× TD–methylphenidate hydrochloride plus 6.7× TD–phenobarbital. The control group, without addition of drug, was maintained under the same conditions of temperature (25 ± 1 °C), humidity (70 ± 10 %), and photoperiod (12 h). Specimens of each group were weighed every 12 h until pupariation. The developmental rate of the three Chrysomya species immatures was monitored. For C. albiceps the developmental time was delayed in 24 h for methylphenidate hydrochloride group and in 12 h for the phenobarbital and the drugs association groups. The effect was observed only at specific ages for C. megacephala, without altering the developmental time. For C. putoria, the developmental time was delayed in 12 h for methylphenidate hydrochloride group and in 24 h for the phenobarbital and the drugs association groups. The emergence interval was similar among all experimental groups, but larval and pupal viabilities were affected in different ways. |
| doi_str_mv | 10.1007/s00436-014-3837-5 |
| format | Article |
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This study aimed to evaluate the effect of different concentrations of methylphenidate hydrochloride, phenobarbital, and their association on the developmental rate, larval and pupal survivorship, and the interval of emergence of adults of Chrysomya albiceps (Wiedemann), Chrysomya megacephala (Fabricius), and Chrysomya putoria (Wiedemann) (Diptera: Calliphoridae). Considering the therapeutic dose (TD) of methylphenidate hydrochloride (0.29 mg/Kg), the concentrations tested were 10× TD, 50× TD, and 100× TD. For phenobarbital, the concentrations used were 1× TD (=150 mg/Kg), 3.3× TD, and 6.7× TD. For the association of the drugs, the combinations used were 10× TD–methylphenidate hydrochloride plus 1× TD–phenobarbital, 50× TD–methylphenidate hydrochloride plus 3.3× TD–phenobarbital, and 100× TD–methylphenidate hydrochloride plus 6.7× TD–phenobarbital. The control group, without addition of drug, was maintained under the same conditions of temperature (25 ± 1 °C), humidity (70 ± 10 %), and photoperiod (12 h). Specimens of each group were weighed every 12 h until pupariation. The developmental rate of the three Chrysomya species immatures was monitored. For C. albiceps the developmental time was delayed in 24 h for methylphenidate hydrochloride group and in 12 h for the phenobarbital and the drugs association groups. The effect was observed only at specific ages for C. megacephala, without altering the developmental time. For C. putoria, the developmental time was delayed in 12 h for methylphenidate hydrochloride group and in 24 h for the phenobarbital and the drugs association groups. The emergence interval was similar among all experimental groups, but larval and pupal viabilities were affected in different ways.</description><identifier>ISSN: 0932-0113</identifier><identifier>EISSN: 1432-1955</identifier><identifier>DOI: 10.1007/s00436-014-3837-5</identifier><identifier>PMID: 24633905</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>adults ; Animals ; Anticonvulsants - pharmacology ; Biomedical and Life Sciences ; Biomedicine ; Blowflies ; Calliphoridae ; Central Nervous System Stimulants - pharmacology ; Chrysomya ; Chrysomya albiceps ; Chrysomya megacephala ; Chrysomya putoria ; Diptera ; Diptera - drug effects ; Diptera - growth & development ; Dosage and administration ; Drug interactions ; Health aspects ; humidity ; immatures ; Immunology ; Larva - drug effects ; Larva - growth & development ; larvae ; Medical Microbiology ; Methylphenidate ; Methylphenidate - pharmacology ; Methylphenidate hydrochloride ; Microbiology ; Original Paper ; Pharmaceutical research ; Phenobarbital ; Phenobarbital - pharmacology ; Photoperiod ; Pupa - drug effects ; pupae ; pupariation ; species ; survival rate ; Temperature ; therapeutics ; Time Factors ; Zoological research</subject><ispartof>Parasitology research (1987), 2014-05, Vol.113 (5), p.1897-1907</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>COPYRIGHT 2014 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-1722ca27e979cfcdaed0408a6d4615b7cb7769f35fe337fc0efd3e4e594278d3</citedby><cites>FETCH-LOGICAL-c501t-1722ca27e979cfcdaed0408a6d4615b7cb7769f35fe337fc0efd3e4e594278d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00436-014-3837-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00436-014-3837-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24633905$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rezende, Fábio</creatorcontrib><creatorcontrib>Alonso, Marcela A</creatorcontrib><creatorcontrib>Souza, Carina M</creatorcontrib><creatorcontrib>Thyssen, Patrícia J</creatorcontrib><creatorcontrib>Linhares, Arício X</creatorcontrib><title>Developmental rates of immatures of three Chrysomya species (Diptera: Calliphoridae) under the effect of methylphenidate hydrochloride, phenobarbital, and methylphenidate hydrochloride associated with phenobarbital</title><title>Parasitology research (1987)</title><addtitle>Parasitol Res</addtitle><addtitle>Parasitol Res</addtitle><description>Entomotoxicology is focused on obtaining data on necrophagous entomofauna, for criminal investigations purposes. This study aimed to evaluate the effect of different concentrations of methylphenidate hydrochloride, phenobarbital, and their association on the developmental rate, larval and pupal survivorship, and the interval of emergence of adults of Chrysomya albiceps (Wiedemann), Chrysomya megacephala (Fabricius), and Chrysomya putoria (Wiedemann) (Diptera: Calliphoridae). Considering the therapeutic dose (TD) of methylphenidate hydrochloride (0.29 mg/Kg), the concentrations tested were 10× TD, 50× TD, and 100× TD. For phenobarbital, the concentrations used were 1× TD (=150 mg/Kg), 3.3× TD, and 6.7× TD. For the association of the drugs, the combinations used were 10× TD–methylphenidate hydrochloride plus 1× TD–phenobarbital, 50× TD–methylphenidate hydrochloride plus 3.3× TD–phenobarbital, and 100× TD–methylphenidate hydrochloride plus 6.7× TD–phenobarbital. The control group, without addition of drug, was maintained under the same conditions of temperature (25 ± 1 °C), humidity (70 ± 10 %), and photoperiod (12 h). Specimens of each group were weighed every 12 h until pupariation. The developmental rate of the three Chrysomya species immatures was monitored. For C. albiceps the developmental time was delayed in 24 h for methylphenidate hydrochloride group and in 12 h for the phenobarbital and the drugs association groups. The effect was observed only at specific ages for C. megacephala, without altering the developmental time. For C. putoria, the developmental time was delayed in 12 h for methylphenidate hydrochloride group and in 24 h for the phenobarbital and the drugs association groups. The emergence interval was similar among all experimental groups, but larval and pupal viabilities were affected in different ways.</description><subject>adults</subject><subject>Animals</subject><subject>Anticonvulsants - pharmacology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blowflies</subject><subject>Calliphoridae</subject><subject>Central Nervous System Stimulants - pharmacology</subject><subject>Chrysomya</subject><subject>Chrysomya albiceps</subject><subject>Chrysomya megacephala</subject><subject>Chrysomya putoria</subject><subject>Diptera</subject><subject>Diptera - drug effects</subject><subject>Diptera - growth & development</subject><subject>Dosage and administration</subject><subject>Drug interactions</subject><subject>Health aspects</subject><subject>humidity</subject><subject>immatures</subject><subject>Immunology</subject><subject>Larva - drug effects</subject><subject>Larva - growth & development</subject><subject>larvae</subject><subject>Medical Microbiology</subject><subject>Methylphenidate</subject><subject>Methylphenidate - pharmacology</subject><subject>Methylphenidate hydrochloride</subject><subject>Microbiology</subject><subject>Original Paper</subject><subject>Pharmaceutical research</subject><subject>Phenobarbital</subject><subject>Phenobarbital - pharmacology</subject><subject>Photoperiod</subject><subject>Pupa - drug effects</subject><subject>pupae</subject><subject>pupariation</subject><subject>species</subject><subject>survival rate</subject><subject>Temperature</subject><subject>therapeutics</subject><subject>Time Factors</subject><subject>Zoological research</subject><issn>0932-0113</issn><issn>1432-1955</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks1u1DAUhSMEotPCA7ABS2yK1BT_xgm7asqfVIkFZW15nOuJqyQOtgOaF-3z4CgFqRIqyAvb937n6Fo-RfGC4HOCsXwbMeasKjHhJauZLMWjYkM4oyVphHhcbHCTz5gQdlQcx3iDMZEV50-LI8orxhosNsXtJfyA3k8DjEn3KOgEEXmL3DDoNIf1kroAgLZdOEQ_HDSKExiXW6eXbkoQ9Du01X3vps4H12p4g-axhZBlgMBaMGkxGSB1h37qYMxMAtQd2uBN1y8aOENLw-902Lk8xxnSY_uwAukYvXG53qKfLnX3DZ4VT6zuIzy_20-K6w_vr7efyqsvHz9vL65KIzBJJZGUGk0lNLIx1uTZW8xxrauWV0TspNlJWTWWCQuMSWsw2JYBB9FwKuuWnRSnq-0U_PcZYlKDiwb6Xo_g56gYEZzUNcPin2gmMWWCifo_UNLQitWSZvT1iu51D8qN1qegzYKrCyYpbrhoFsPzv1B5tTA440ewLtfvCcgqMMHHGMCqKbhBh4MiWC3RU2v0VI6eWqKnlge-vJt63g3Q_lH8zloG6ArE3Br3ENSNn8OYv-dB11eryGqv9D64qL59pRnAmc_RluwXzDLxcw</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Rezende, Fábio</creator><creator>Alonso, Marcela A</creator><creator>Souza, Carina M</creator><creator>Thyssen, Patrícia J</creator><creator>Linhares, Arício X</creator><general>Springer-Verlag</general><general>Springer Berlin Heidelberg</general><general>Springer</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SS</scope><scope>M7N</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20140501</creationdate><title>Developmental rates of immatures of three Chrysomya species (Diptera: Calliphoridae) under the effect of methylphenidate hydrochloride, phenobarbital, and methylphenidate hydrochloride associated with phenobarbital</title><author>Rezende, Fábio ; Alonso, Marcela A ; Souza, Carina M ; Thyssen, Patrícia J ; Linhares, Arício X</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c501t-1722ca27e979cfcdaed0408a6d4615b7cb7769f35fe337fc0efd3e4e594278d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>adults</topic><topic>Animals</topic><topic>Anticonvulsants - pharmacology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blowflies</topic><topic>Calliphoridae</topic><topic>Central Nervous System Stimulants - pharmacology</topic><topic>Chrysomya</topic><topic>Chrysomya albiceps</topic><topic>Chrysomya megacephala</topic><topic>Chrysomya putoria</topic><topic>Diptera</topic><topic>Diptera - drug effects</topic><topic>Diptera - growth & development</topic><topic>Dosage and administration</topic><topic>Drug interactions</topic><topic>Health aspects</topic><topic>humidity</topic><topic>immatures</topic><topic>Immunology</topic><topic>Larva - drug effects</topic><topic>Larva - growth & development</topic><topic>larvae</topic><topic>Medical Microbiology</topic><topic>Methylphenidate</topic><topic>Methylphenidate - pharmacology</topic><topic>Methylphenidate hydrochloride</topic><topic>Microbiology</topic><topic>Original Paper</topic><topic>Pharmaceutical research</topic><topic>Phenobarbital</topic><topic>Phenobarbital - pharmacology</topic><topic>Photoperiod</topic><topic>Pupa - drug effects</topic><topic>pupae</topic><topic>pupariation</topic><topic>species</topic><topic>survival rate</topic><topic>Temperature</topic><topic>therapeutics</topic><topic>Time Factors</topic><topic>Zoological research</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rezende, Fábio</creatorcontrib><creatorcontrib>Alonso, Marcela A</creatorcontrib><creatorcontrib>Souza, Carina M</creatorcontrib><creatorcontrib>Thyssen, Patrícia J</creatorcontrib><creatorcontrib>Linhares, Arício X</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Parasitology research (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rezende, Fábio</au><au>Alonso, Marcela A</au><au>Souza, Carina M</au><au>Thyssen, Patrícia J</au><au>Linhares, Arício X</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Developmental rates of immatures of three Chrysomya species (Diptera: Calliphoridae) under the effect of methylphenidate hydrochloride, phenobarbital, and methylphenidate hydrochloride associated with phenobarbital</atitle><jtitle>Parasitology research (1987)</jtitle><stitle>Parasitol Res</stitle><addtitle>Parasitol Res</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>113</volume><issue>5</issue><spage>1897</spage><epage>1907</epage><pages>1897-1907</pages><issn>0932-0113</issn><eissn>1432-1955</eissn><abstract>Entomotoxicology is focused on obtaining data on necrophagous entomofauna, for criminal investigations purposes. This study aimed to evaluate the effect of different concentrations of methylphenidate hydrochloride, phenobarbital, and their association on the developmental rate, larval and pupal survivorship, and the interval of emergence of adults of Chrysomya albiceps (Wiedemann), Chrysomya megacephala (Fabricius), and Chrysomya putoria (Wiedemann) (Diptera: Calliphoridae). Considering the therapeutic dose (TD) of methylphenidate hydrochloride (0.29 mg/Kg), the concentrations tested were 10× TD, 50× TD, and 100× TD. For phenobarbital, the concentrations used were 1× TD (=150 mg/Kg), 3.3× TD, and 6.7× TD. For the association of the drugs, the combinations used were 10× TD–methylphenidate hydrochloride plus 1× TD–phenobarbital, 50× TD–methylphenidate hydrochloride plus 3.3× TD–phenobarbital, and 100× TD–methylphenidate hydrochloride plus 6.7× TD–phenobarbital. The control group, without addition of drug, was maintained under the same conditions of temperature (25 ± 1 °C), humidity (70 ± 10 %), and photoperiod (12 h). Specimens of each group were weighed every 12 h until pupariation. The developmental rate of the three Chrysomya species immatures was monitored. For C. albiceps the developmental time was delayed in 24 h for methylphenidate hydrochloride group and in 12 h for the phenobarbital and the drugs association groups. The effect was observed only at specific ages for C. megacephala, without altering the developmental time. For C. putoria, the developmental time was delayed in 12 h for methylphenidate hydrochloride group and in 24 h for the phenobarbital and the drugs association groups. The emergence interval was similar among all experimental groups, but larval and pupal viabilities were affected in different ways.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>24633905</pmid><doi>10.1007/s00436-014-3837-5</doi><tpages>11</tpages></addata></record> |
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| identifier | ISSN: 0932-0113 |
| ispartof | Parasitology research (1987), 2014-05, Vol.113 (5), p.1897-1907 |
| issn | 0932-0113 1432-1955 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | adults Animals Anticonvulsants - pharmacology Biomedical and Life Sciences Biomedicine Blowflies Calliphoridae Central Nervous System Stimulants - pharmacology Chrysomya Chrysomya albiceps Chrysomya megacephala Chrysomya putoria Diptera Diptera - drug effects Diptera - growth & development Dosage and administration Drug interactions Health aspects humidity immatures Immunology Larva - drug effects Larva - growth & development larvae Medical Microbiology Methylphenidate Methylphenidate - pharmacology Methylphenidate hydrochloride Microbiology Original Paper Pharmaceutical research Phenobarbital Phenobarbital - pharmacology Photoperiod Pupa - drug effects pupae pupariation species survival rate Temperature therapeutics Time Factors Zoological research |
| title | Developmental rates of immatures of three Chrysomya species (Diptera: Calliphoridae) under the effect of methylphenidate hydrochloride, phenobarbital, and methylphenidate hydrochloride associated with phenobarbital |
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