Evaluation of the efficacy of afoxolaner against Haemaphysalis longicornis on dogs
A controlled study to assess the acaricidal efficacy of afoxolaner in dogs after a single oral administration was conducted against Haemaphysalis longicornis ticks. The study was characterized by a negative controlled randomized block design and included sixteen beagle dogs of both sexes. Starting t...
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| Veröffentlicht in: | Veterinary parasitology 2014-04, Vol.201 (3-4), p.229-231 |
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| container_title | Veterinary parasitology |
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| creator | Kondo, Yumi Kinoshita, Gen Drag, Marlene Chester, Theodore S. Larsen, Diane |
| description | A controlled study to assess the acaricidal efficacy of afoxolaner in dogs after a single oral administration was conducted against Haemaphysalis longicornis ticks. The study was characterized by a negative controlled randomized block design and included sixteen beagle dogs of both sexes. Starting two days before treatment, each dog was infested weekly with 50 ticks over 4 weeks. The number of live ticks was determined 48h after treatment and then 48h after each infestation. The mean dose of afoxolaner received by dogs was 3.0mg/kg (range: 2.5–3.1mg/kg). Afoxolaner rapidly eliminated pre-existing tick infestations (100% ticks killed within 48h of treatment) and controlled weekly re-infestations (91.9% prophylactic efficacy at Day 30). |
| doi_str_mv | 10.1016/j.vetpar.2014.02.019 |
| format | Article |
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Afoxolaner rapidly eliminated pre-existing tick infestations (100% ticks killed within 48h of treatment) and controlled weekly re-infestations (91.9% prophylactic efficacy at Day 30).</description><subject>Acaricides - therapeutic use</subject><subject>Afoxolaner</subject><subject>Animals</subject><subject>Dog</subject><subject>Dog Diseases - drug therapy</subject><subject>Dog Diseases - prevention & control</subject><subject>Dogs</subject><subject>Efficacy</subject><subject>Female</subject><subject>Haemaphysalis longicornis</subject><subject>Isoxazoles - administration & dosage</subject><subject>Ixodidae</subject><subject>Male</subject><subject>Naphthalenes - administration & dosage</subject><subject>Random Allocation</subject><subject>Tick</subject><subject>Tick Infestations - drug therapy</subject><subject>Tick Infestations - prevention & control</subject><subject>Tick Infestations - veterinary</subject><subject>Treatment Outcome</subject><issn>0304-4017</issn><issn>1873-2550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1Lw0AQhhdRtH78A5EcvSTObiZfF0GkfoAgiJ6XyWZSt6TZupsW--9NqXoUTzMDzzszPEKcS0gkyPxqnqx5WJJPFEhMQCUgqz0xkWWRxirLYF9MIAWMEWRxJI5DmAMAQl4ciiOFuapQVRPxMl1Tt6LBuj5ybTS8c8Rtaw2ZzXam1n26jnr2Ec3I9mGIHogXtHzfBOpsiDrXz6xxvh_7cUXjZuFUHLTUBT77rifi7W76evsQPz3fP97ePMUGUQ5xXROmbc5VrUrKamVKCRVVZdk0UBBhhlVBaQ1ZUTYEVWlkzW1tWEoEhdykJ-Jyt3fp3ceKw6AXNhjutu-6VdAyG8EUizz_ByoRFZaYjijuUONdCJ5bvfR2QX6jJeiteD3XO_F6K16D0qP4MXbxfWFVL7j5Df2YHoHrHcCjkrVlr4Ox3BturGcz6MbZvy98Aa3Nlqs</recordid><startdate>20140402</startdate><enddate>20140402</enddate><creator>Kondo, Yumi</creator><creator>Kinoshita, Gen</creator><creator>Drag, Marlene</creator><creator>Chester, Theodore S.</creator><creator>Larsen, Diane</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SS</scope></search><sort><creationdate>20140402</creationdate><title>Evaluation of the efficacy of afoxolaner against Haemaphysalis longicornis on dogs</title><author>Kondo, Yumi ; Kinoshita, Gen ; Drag, Marlene ; Chester, Theodore S. ; Larsen, Diane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-bba43f6e9b28a5b2c8109a988dd07aa45497a3b0578da098c1befbce114024ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acaricides - therapeutic use</topic><topic>Afoxolaner</topic><topic>Animals</topic><topic>Dog</topic><topic>Dog Diseases - drug therapy</topic><topic>Dog Diseases - prevention & control</topic><topic>Dogs</topic><topic>Efficacy</topic><topic>Female</topic><topic>Haemaphysalis longicornis</topic><topic>Isoxazoles - administration & dosage</topic><topic>Ixodidae</topic><topic>Male</topic><topic>Naphthalenes - administration & dosage</topic><topic>Random Allocation</topic><topic>Tick</topic><topic>Tick Infestations - drug therapy</topic><topic>Tick Infestations - prevention & control</topic><topic>Tick Infestations - veterinary</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kondo, Yumi</creatorcontrib><creatorcontrib>Kinoshita, Gen</creatorcontrib><creatorcontrib>Drag, Marlene</creatorcontrib><creatorcontrib>Chester, Theodore S.</creatorcontrib><creatorcontrib>Larsen, Diane</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Entomology Abstracts (Full archive)</collection><jtitle>Veterinary parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kondo, Yumi</au><au>Kinoshita, Gen</au><au>Drag, Marlene</au><au>Chester, Theodore S.</au><au>Larsen, Diane</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the efficacy of afoxolaner against Haemaphysalis longicornis on dogs</atitle><jtitle>Veterinary parasitology</jtitle><addtitle>Vet Parasitol</addtitle><date>2014-04-02</date><risdate>2014</risdate><volume>201</volume><issue>3-4</issue><spage>229</spage><epage>231</epage><pages>229-231</pages><issn>0304-4017</issn><eissn>1873-2550</eissn><abstract>A controlled study to assess the acaricidal efficacy of afoxolaner in dogs after a single oral administration was conducted against Haemaphysalis longicornis ticks. 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| ispartof | Veterinary parasitology, 2014-04, Vol.201 (3-4), p.229-231 |
| issn | 0304-4017 1873-2550 |
| language | eng |
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| source | MEDLINE; ScienceDirect Freedom Collection (Elsevier) |
| subjects | Acaricides - therapeutic use Afoxolaner Animals Dog Dog Diseases - drug therapy Dog Diseases - prevention & control Dogs Efficacy Female Haemaphysalis longicornis Isoxazoles - administration & dosage Ixodidae Male Naphthalenes - administration & dosage Random Allocation Tick Tick Infestations - drug therapy Tick Infestations - prevention & control Tick Infestations - veterinary Treatment Outcome |
| title | Evaluation of the efficacy of afoxolaner against Haemaphysalis longicornis on dogs |
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