c-Src and Pyk2 Protein Tyrosine Kinases Play Protective Roles in Early HIV-1 Infection of CD4+ T-Cell Lines

BACKGROUND:During early HIV-1 infection of CD4 T-lymphocytes, many host protein tyrosine kinases become activated within minutes, including phosphoprotein pp60 (c-Src) and the focal adhesion kinase family member, proline-rich tyrosine kinase 2 (Pyk2). Whether their activation facilitates or impedes...

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Veröffentlicht in:	Journal of acquired immune deficiency syndromes (1999) 2014-06, Vol.66 (2), p.118-126
Hauptverfasser:	McCarthy, Stephen D.S, Jung, Daniel, Sakac, Darinka, Branch, Donald R
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV CD4-Positive T-Lymphocytes - virology Cell Line, Tumor Deoxyribonucleic acid DNA DNA, Viral - isolation & purification Focal Adhesion Kinase 2 - antagonists & inhibitors Focal Adhesion Kinase 2 - genetics Focal Adhesion Kinase 2 - metabolism HIV HIV Infections - metabolism HIV-1 - physiology Human immunodeficiency virus Humans Indoles - pharmacology Kinases Lymphocytes Membrane Glycoproteins - metabolism Phosphorylation Proteins Pyrazoles - pharmacology Pyrimidines - pharmacology src-Family Kinases - antagonists & inhibitors src-Family Kinases - genetics src-Family Kinases - metabolism Sulfonamides - pharmacology T cell receptors Transduction, Genetic Viral Envelope Proteins - metabolism
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