Therapeutic efficacy of three bispecific antibodies on collagen-induced arthritis mouse model

Interleukin-1β (IL-1β) and interleukin-17A (IL-17A) are inducible factors and important cytokines in the pathogenesis of rheumatoid arthritis (RA). In the present study, three bispecific and neutralizing antibodies (BsAB-1, BsAB-2 and BsAB-3) against both hIL-1β and hIL-17A were constructed, their t...

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Veröffentlicht in:	International immunopharmacology 2014-07, Vol.21 (1), p.119-127
Hauptverfasser:	Li, Qingcui, Ren, Guiping, Xu, Liming, Wang, Qiuying, Qi, Jianying, Wang, Wenfei, Zhou, Bing, Han, Xiaohui, Sun, Cuiyu, Wu, Qiang, Yu, Yinhang, Peng, Zhongyi, Zheng, Shimin, Li, Deshan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Bispecific - administration & dosage Antibodies, Bispecific - genetics Antibodies, Blocking - administration & dosage Antibodies, Blocking - genetics Antibody Formation - drug effects Arthritis, Experimental - immunology Arthritis, Experimental - therapy Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - therapy Bispecific antibody Bone and Bones - drug effects Bone and Bones - pathology Cells, Cultured Cytokines - genetics Cytokines - metabolism Disease Models, Animal Down-Regulation Humans IL-17A IL-1β Interleukin-17 - immunology Interleukin-1beta - immunology Male Mice Mice, Inbred Strains Rheumatoid arthritis (RA)
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