Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4

Retinol-Binding Protein 4 (RBP4) is a plasma protein that transports retinol (vitamin A) from the liver to peripheral tissues. This Letter highlights our efforts in discovering the first, to our knowledge, non-retinoid small molecules that bind to RBP4 at the retinol site and reduce serum RBP4 level...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2014-07, Vol.24 (13), p.2885-2891
Hauptverfasser:	Wang, Yingcai, Connors, Richard, Fan, Pingchen, Wang, Xiaodong, Wang, Zhongyu, Liu, Jiwen, Kayser, Frank, Medina, Julio C, Johnstone, Sheree, Xu, Haoda, Thibault, Stephen, Walker, Nigel, Conn, Marion, Zhang, Ying, Liu, Qingxiang, Grillo, Mark P, Motani, Alykhan, Coward, Peter, Wang, Zhulun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Crystallography, X-Ray Dose-Response Relationship, Drug Drug Discovery Humans Ligands Male Mice Models, Molecular Molecular Structure Rats Retinol-Binding Proteins, Plasma - antagonists & inhibitors Retinol-Binding Proteins, Plasma - metabolism Small Molecule Libraries - chemical synthesis Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology Structure-Activity Relationship Vitamin A - blood
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