Suppression of CXCL2 upregulation underlies the therapeutic effect of the retinoid Am80 on intracerebral hemorrhage in mice

We previously demonstrated that a synthetic retinoic acid receptor agonist, Am80, attenuated intracerebral hemorrhage (ICH)‐induced neuropathological changes and neurological dysfunction. Because inflammatory events are among the prominent features of ICH pathology that are affected by Am80, this st...

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Veröffentlicht in:	Journal of neuroscience research 2014-08, Vol.92 (8), p.1024-1034
Hauptverfasser:	Matsushita, Hideaki, Hijioka, Masanori, Ishibashi, Hayato, Anan, Junpei, Kurauchi, Yuki, Hisatsune, Akinori, Seki, Takahiro, Shudo, Koichi, Katsuki, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzoates - pharmacology Benzoates - therapeutic use Cerebral Hemorrhage - drug therapy Cerebral Hemorrhage - metabolism Cerebral Hemorrhage - pathology Chemokine CXCL2 - genetics Chemokine CXCL2 - metabolism CXC chemokine Cytokines - genetics Cytokines - metabolism Disease Models, Animal hemorrhagic stroke inflammation Male Mice Mice, Inbred C57BL Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use retinoic acid receptor Sulfonamides - pharmacology Sulfonamides - therapeutic use tamibarotene Tetrahydronaphthalenes - pharmacology Tetrahydronaphthalenes - therapeutic use Up-Regulation - drug effects
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