Sinomenine inhibits microglia activation and attenuates brain injury in intracerebral hemorrhage

•We treated ICH-challenged BV2 microglial cells with sinomenine in vitro, and explored its neuroprotection role in intracerebral hemorrhage in vivo.•Sinomenine could inhibit the release of these cytokines and attenuate ROS production in a dose-dependent manner, and reduce NF-κB activation.•Sinomenin...

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Veröffentlicht in:	Molecular immunology 2014-08, Vol.60 (2), p.109-114
Hauptverfasser:	Yang, Zhao, Liu, Yongping, Yuan, Fang, Li, Zhen, Huang, Shaokuan, Shen, Hanchao, Yuan, Bangqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Injuries - drug therapy Brain Injuries - immunology Cell Line Cell Movement - drug effects Cell Movement - immunology Cerebral Hemorrhage - drug therapy Cerebral Hemorrhage - immunology Inflammation - drug therapy Inflammation - immunology Interleukin-1beta - immunology Interleukin-6 - immunology Intracerebral hemorrhage Male Mice Mice, Inbred C57BL Microglia Microglia - drug effects Microglia - immunology Morphinans - pharmacology Neuroprotective Agents - immunology Neuroprotective Agents - pharmacology NF-kappa B - immunology Reactive Oxygen Species - immunology Sinomenine Tumor Necrosis Factor-alpha - immunology
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