High‐Content Analysis/Screening for Predictive Toxicology: Application to Hepatotoxicity and Genotoxicity

High‐content imaging/analysis has emerged as a powerful tool for predictive toxicology as it can be used for identifying and mitigating potential safety risks during drug discovery. By careful selection of end‐points, some cellular assays can show better predictivity than routine animal toxicity tes...

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Veröffentlicht in:Basic & clinical pharmacology & toxicology 2014-07, Vol.115 (1), p.18-23
Hauptverfasser: Persson, Mikael, Løye, Anni F., Jacquet, Mélanie, Mow, Natacha S., Thougaard, Annemette V., Mow, Tomas, Hornberg, Jorrit J.
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Sprache:eng
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