2‐Methoxyestradiol confers neuroprotection and inhibits a maladaptive HIF‐1α response after traumatic brain injury in mice

HIF‐1α is pivotal for cellular homeostasis in response to cerebral ischemia. Pharmacological inhibition of HIF‐1α may reduce secondary brain damage by targeting post‐translational mechanisms associated with its proteasomal degradation and nuclear translocation. This study examined the neuroprotectiv...

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Veröffentlicht in:	Journal of neurochemistry 2014-06, Vol.129 (6), p.940-954
Hauptverfasser:	Schaible, Eva‐Verena, Windschügl, Julia, Bobkiewicz, Wiesia, Kaburov, Yordan, Dangel, Larissa, Krämer, Tobias, Huang, Changsheng, Sebastiani, Anne, Luh, Clara, Werner, Christian, Engelhard, Kristin, Thal, Serge C., Schäfer, Michael K.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	2‐methoxyestradiol Alternative Splicing Animals Blotting, Western Brain Injuries - drug therapy Brain Injuries - metabolism Brain Ischemia - drug therapy Brain Ischemia - metabolism Brain Ischemia - pathology Cell Nucleus - metabolism cerebral ischemia Estradiol - analogs & derivatives Estradiol - pharmacology Exons - genetics Gene Expression Regulation - drug effects HIF‐1 Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors Immunohistochemistry Injections, Intraperitoneal Male Membrane Proteins - biosynthesis Mice Mice, Inbred C57BL Mitochondrial Proteins - biosynthesis Neurons - metabolism neuroprotection Neuroprotective Agents Plasminogen Activator Inhibitor 1 - metabolism Protein Transport Subcellular Fractions - metabolism traumatic brain injury Tumor Necrosis Factor-alpha - metabolism Up-Regulation - genetics Up-Regulation - physiology
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