Purinergic signaling via P2Y receptors up-mediates IL-6 production by liver macrophages/Kupffer cells

Resident macrophages in the liver (Kupffer cells) produce various cytokines and chemokines, and have important roles in hepatitis and liver fibrosis. The cells are activated by various factors, for example lipopolysaccharide (LPS), which is an endotoxin and is high in the blood of patients with live...

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Veröffentlicht in:	Journal of toxicological sciences 2014/06/01, Vol.39(3), pp.413-423
Hauptverfasser:	Ishimaru, Makiko, Yusuke, Negishi, Tsukimoto, Mitsutoshi, Harada, Hitoshi, Takenouchi, Takato, Kitani, Hiroshi, Kojima, Shuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - pharmacology Animals Azo Compounds - pharmacology Cells, Cultured Drug Discovery Hepatitis Hepatitis - drug therapy Hepatitis - genetics IL-6 production Inflammation Mediators - metabolism Interleukin-6 - metabolism Kupffer cells Kupffer Cells - metabolism Lipopolysaccharides - adverse effects Liver - cytology Macrophages - metabolism Mice, Inbred C57BL Molecular Targeted Therapy P2Y receptors Purinergic P2Y Receptor Agonists - pharmacology Purinergic P2Y Receptor Antagonists - pharmacology Purinergic signaling Pyridoxal Phosphate - analogs & derivatives Pyridoxal Phosphate - pharmacology Receptors, Purinergic P2Y - physiology Signal Transduction - physiology Suramin - pharmacology Tumor Necrosis Factor-alpha - metabolism Up-Regulation - genetics
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