Use of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography to aid in diagnosing intestinal adenocarcinoma in 2 rhesus macaques (Macaca mulatta)
Two aged female rhesus macaques (Macaca mulatta) presented with weight loss and intermittent inappetence. The signalment and constellation of clinical signs led clinicians to suspect the presence of intestinal adenocarcinoma. Because of each animal's advanced age and inconclusive radiographic f...
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| Veröffentlicht in: | Comparative medicine 2014-06, Vol.64 (3), p.211-220 |
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| creator | Caporizzo, Debra J Kwiatkowski, Anna E Chen, Ming-Kai Beck, Amanda P Booth, Carmen J Zeiss, Caroline Smith, Peter C Carlson Scholz, Jodi A Wilson, Steven R |
| description | Two aged female rhesus macaques (Macaca mulatta) presented with weight loss and intermittent inappetence. The signalment and constellation of clinical signs led clinicians to suspect the presence of intestinal adenocarcinoma. Because of each animal's advanced age and inconclusive radiographic findings, a noninvasive diagnostic tool was preferred over exploratory laparotomy to assist in determining a diagnosis. Consequently, 2-[(18)F]fluoro-2-deoxy-d-glucose (FDG) positron emission tomography-CT (FDG-PET-CT) was chosen to aid in confirming a suspicion of gastrointestinal adenocarcinoma in both animals. FDG is a glucose analogue labeled with fluorine-18 and is taken up by highly metabolically active cells, as observed in many cancers. Tomography revealed an annular constriction of the small intestine with focal FDG uptake in one animal, and an FDG avid transmural mass in the ascending colon of the second animal. Necropsy later confirmed both sites to be adenocarcinomas. This report supports the use of FDG-PET-CT as an adjunct to conventional radiography in the diagnosis of intestinal adenocarcinoma in nonhuman primates. |
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The signalment and constellation of clinical signs led clinicians to suspect the presence of intestinal adenocarcinoma. Because of each animal's advanced age and inconclusive radiographic findings, a noninvasive diagnostic tool was preferred over exploratory laparotomy to assist in determining a diagnosis. Consequently, 2-[(18)F]fluoro-2-deoxy-d-glucose (FDG) positron emission tomography-CT (FDG-PET-CT) was chosen to aid in confirming a suspicion of gastrointestinal adenocarcinoma in both animals. FDG is a glucose analogue labeled with fluorine-18 and is taken up by highly metabolically active cells, as observed in many cancers. Tomography revealed an annular constriction of the small intestine with focal FDG uptake in one animal, and an FDG avid transmural mass in the ascending colon of the second animal. Necropsy later confirmed both sites to be adenocarcinomas. This report supports the use of FDG-PET-CT as an adjunct to conventional radiography in the diagnosis of intestinal adenocarcinoma in nonhuman primates.</description><identifier>ISSN: 1532-0820</identifier><identifier>PMID: 24956213</identifier><language>eng</language><publisher>United States</publisher><subject>Adenocarcinoma - diagnosis ; Adenocarcinoma - veterinary ; Animals ; Female ; Fluorodeoxyglucose F18 ; Intestinal Neoplasms - diagnosis ; Intestinal Neoplasms - veterinary ; Macaca mulatta ; Monkey Diseases - diagnosis ; Positron-Emission Tomography - methods</subject><ispartof>Comparative medicine, 2014-06, Vol.64 (3), p.211-220</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24956213$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caporizzo, Debra J</creatorcontrib><creatorcontrib>Kwiatkowski, Anna E</creatorcontrib><creatorcontrib>Chen, Ming-Kai</creatorcontrib><creatorcontrib>Beck, Amanda P</creatorcontrib><creatorcontrib>Booth, Carmen J</creatorcontrib><creatorcontrib>Zeiss, Caroline</creatorcontrib><creatorcontrib>Smith, Peter C</creatorcontrib><creatorcontrib>Carlson Scholz, Jodi A</creatorcontrib><creatorcontrib>Wilson, Steven R</creatorcontrib><title>Use of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography to aid in diagnosing intestinal adenocarcinoma in 2 rhesus macaques (Macaca mulatta)</title><title>Comparative medicine</title><addtitle>Comp Med</addtitle><description>Two aged female rhesus macaques (Macaca mulatta) presented with weight loss and intermittent inappetence. The signalment and constellation of clinical signs led clinicians to suspect the presence of intestinal adenocarcinoma. Because of each animal's advanced age and inconclusive radiographic findings, a noninvasive diagnostic tool was preferred over exploratory laparotomy to assist in determining a diagnosis. Consequently, 2-[(18)F]fluoro-2-deoxy-d-glucose (FDG) positron emission tomography-CT (FDG-PET-CT) was chosen to aid in confirming a suspicion of gastrointestinal adenocarcinoma in both animals. FDG is a glucose analogue labeled with fluorine-18 and is taken up by highly metabolically active cells, as observed in many cancers. Tomography revealed an annular constriction of the small intestine with focal FDG uptake in one animal, and an FDG avid transmural mass in the ascending colon of the second animal. Necropsy later confirmed both sites to be adenocarcinomas. This report supports the use of FDG-PET-CT as an adjunct to conventional radiography in the diagnosis of intestinal adenocarcinoma in nonhuman primates.</description><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - veterinary</subject><subject>Animals</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Intestinal Neoplasms - diagnosis</subject><subject>Intestinal Neoplasms - veterinary</subject><subject>Macaca mulatta</subject><subject>Monkey Diseases - diagnosis</subject><subject>Positron-Emission Tomography - methods</subject><issn>1532-0820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtOwzAQRbMA0fL4BeRlu4jkR9zES1RRQCpiQ9fR1I_UKLZD7Ej0g_hPXFEkVnNn5szVzFwUc8IZLXFD8ay4jvEDYyoEplfFjFaCryhh8-J7FzUKBi1Is9yUpp_CGJQOX8eun2TIvSFEm8bgkXY2RptFCi50IwyHYymDG6ak1b9algisQtYjZaHzedx3OUs6JuuhR6C0DxJGaX1wcOIoGg86ThE5kPA56YgWr1lJQG7qISVY3haXBvqo787xpthtHt_Xz-X27ell_bAtB0JXqayoVHsOxNCaYQ01N0oxIrgRWPJKKwKSaIMbrhqCRb0SDTWi3leswUBBG3ZTLH59hzGcFkltPlrqvgevwxRbwitMWM1qnNH7MzrtnVbtMFoH47H9ey37Ab9jd_k</recordid><startdate>201406</startdate><enddate>201406</enddate><creator>Caporizzo, Debra J</creator><creator>Kwiatkowski, Anna E</creator><creator>Chen, Ming-Kai</creator><creator>Beck, Amanda P</creator><creator>Booth, Carmen J</creator><creator>Zeiss, Caroline</creator><creator>Smith, Peter C</creator><creator>Carlson Scholz, Jodi A</creator><creator>Wilson, Steven R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201406</creationdate><title>Use of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography to aid in diagnosing intestinal adenocarcinoma in 2 rhesus macaques (Macaca mulatta)</title><author>Caporizzo, Debra J ; Kwiatkowski, Anna E ; Chen, Ming-Kai ; Beck, Amanda P ; Booth, Carmen J ; Zeiss, Caroline ; Smith, Peter C ; Carlson Scholz, Jodi A ; Wilson, Steven R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-42cdb5a1f2730ea75fdd3195f90c54ed1ac1ef085d810976982f97b4380a2aef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adenocarcinoma - diagnosis</topic><topic>Adenocarcinoma - veterinary</topic><topic>Animals</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Intestinal Neoplasms - diagnosis</topic><topic>Intestinal Neoplasms - veterinary</topic><topic>Macaca mulatta</topic><topic>Monkey Diseases - diagnosis</topic><topic>Positron-Emission Tomography - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caporizzo, Debra J</creatorcontrib><creatorcontrib>Kwiatkowski, Anna E</creatorcontrib><creatorcontrib>Chen, Ming-Kai</creatorcontrib><creatorcontrib>Beck, Amanda P</creatorcontrib><creatorcontrib>Booth, Carmen J</creatorcontrib><creatorcontrib>Zeiss, Caroline</creatorcontrib><creatorcontrib>Smith, Peter C</creatorcontrib><creatorcontrib>Carlson Scholz, Jodi A</creatorcontrib><creatorcontrib>Wilson, Steven R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Comparative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caporizzo, Debra J</au><au>Kwiatkowski, Anna E</au><au>Chen, Ming-Kai</au><au>Beck, Amanda P</au><au>Booth, Carmen J</au><au>Zeiss, Caroline</au><au>Smith, Peter C</au><au>Carlson Scholz, Jodi A</au><au>Wilson, Steven R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography to aid in diagnosing intestinal adenocarcinoma in 2 rhesus macaques (Macaca mulatta)</atitle><jtitle>Comparative medicine</jtitle><addtitle>Comp Med</addtitle><date>2014-06</date><risdate>2014</risdate><volume>64</volume><issue>3</issue><spage>211</spage><epage>220</epage><pages>211-220</pages><issn>1532-0820</issn><abstract>Two aged female rhesus macaques (Macaca mulatta) presented with weight loss and intermittent inappetence. The signalment and constellation of clinical signs led clinicians to suspect the presence of intestinal adenocarcinoma. Because of each animal's advanced age and inconclusive radiographic findings, a noninvasive diagnostic tool was preferred over exploratory laparotomy to assist in determining a diagnosis. Consequently, 2-[(18)F]fluoro-2-deoxy-d-glucose (FDG) positron emission tomography-CT (FDG-PET-CT) was chosen to aid in confirming a suspicion of gastrointestinal adenocarcinoma in both animals. FDG is a glucose analogue labeled with fluorine-18 and is taken up by highly metabolically active cells, as observed in many cancers. Tomography revealed an annular constriction of the small intestine with focal FDG uptake in one animal, and an FDG avid transmural mass in the ascending colon of the second animal. Necropsy later confirmed both sites to be adenocarcinomas. This report supports the use of FDG-PET-CT as an adjunct to conventional radiography in the diagnosis of intestinal adenocarcinoma in nonhuman primates.</abstract><cop>United States</cop><pmid>24956213</pmid><tpages>10</tpages></addata></record> |
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| ispartof | Comparative medicine, 2014-06, Vol.64 (3), p.211-220 |
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| source | MEDLINE; IngentaConnect Free/Open Access Journals; Ingenta Connect; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adenocarcinoma - diagnosis Adenocarcinoma - veterinary Animals Female Fluorodeoxyglucose F18 Intestinal Neoplasms - diagnosis Intestinal Neoplasms - veterinary Macaca mulatta Monkey Diseases - diagnosis Positron-Emission Tomography - methods |
| title | Use of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography to aid in diagnosing intestinal adenocarcinoma in 2 rhesus macaques (Macaca mulatta) |
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