Room temperature Q-band electron magnetic resonance study of radicals in X-ray-irradiated l-threonine single crystals
In the past, decennia radiation-induced radicals were successfully identified by electron magnetic resonance (EMR) in several solid-state amino acids and sugars. The authors present a room temperature (RT) EMR study of the stable radicals produced by X-ray-irradiation in the amino acid l-threonine (...
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| Veröffentlicht in: | Radiation protection dosimetry 2014-06, Vol.159 (1-4), p.155-163 |
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| creator | Vanhaelewyn, Gauthier Vrielinck, Henk Callens, Freddy |
| description | In the past, decennia radiation-induced radicals were successfully identified by electron magnetic resonance (EMR) in several solid-state amino acids and sugars. The authors present a room temperature (RT) EMR study of the stable radicals produced by X-ray-irradiation in the amino acid l-threonine (CH₃CH(OH)CH(NH₃ (+))COO(-)). Its chemical structure is similar to that of the well-known dosimetric material l-alanine (CH₃CH(NH₃(+))COO(-)), and radiation defects in l-threonine may straightforwardly be compared with the extensively studied l-alanine radicals. The hyperfine coupling tensors of three different radicals were determined at RT using electron nuclear double resonance. These results indicate that the two most abundant radicals share the same basic structure CH₃(•)C(OH)CH(NH₃(+))COO(-), obtained by H-abstraction, but are stabilised in slightly different conformations. The third radical is most probably obtained by deamination (CH₃CH(OH)(•)CHCOO(-)), similar in structure to the stable alanine radical. |
| doi_str_mv | 10.1093/rpd/ncu123 |
| format | Article |
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The authors present a room temperature (RT) EMR study of the stable radicals produced by X-ray-irradiation in the amino acid l-threonine (CH₃CH(OH)CH(NH₃ (+))COO(-)). Its chemical structure is similar to that of the well-known dosimetric material l-alanine (CH₃CH(NH₃(+))COO(-)), and radiation defects in l-threonine may straightforwardly be compared with the extensively studied l-alanine radicals. The hyperfine coupling tensors of three different radicals were determined at RT using electron nuclear double resonance. These results indicate that the two most abundant radicals share the same basic structure CH₃(•)C(OH)CH(NH₃(+))COO(-), obtained by H-abstraction, but are stabilised in slightly different conformations. The third radical is most probably obtained by deamination (CH₃CH(OH)(•)CHCOO(-)), similar in structure to the stable alanine radical.</description><identifier>ISSN: 0144-8420</identifier><identifier>EISSN: 1742-3406</identifier><identifier>DOI: 10.1093/rpd/ncu123</identifier><identifier>PMID: 24748488</identifier><language>eng</language><publisher>England</publisher><subject>Crystallization ; Electron Spin Resonance Spectroscopy - methods ; Free Radicals - chemistry ; Free Radicals - radiation effects ; Humans ; Radiometry - methods ; Temperature ; Threonine - chemistry ; Threonine - radiation effects ; X-Rays</subject><ispartof>Radiation protection dosimetry, 2014-06, Vol.159 (1-4), p.155-163</ispartof><rights>The Author 2014. Published by Oxford University Press. All rights reserved. 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The authors present a room temperature (RT) EMR study of the stable radicals produced by X-ray-irradiation in the amino acid l-threonine (CH₃CH(OH)CH(NH₃ (+))COO(-)). Its chemical structure is similar to that of the well-known dosimetric material l-alanine (CH₃CH(NH₃(+))COO(-)), and radiation defects in l-threonine may straightforwardly be compared with the extensively studied l-alanine radicals. The hyperfine coupling tensors of three different radicals were determined at RT using electron nuclear double resonance. These results indicate that the two most abundant radicals share the same basic structure CH₃(•)C(OH)CH(NH₃(+))COO(-), obtained by H-abstraction, but are stabilised in slightly different conformations. The third radical is most probably obtained by deamination (CH₃CH(OH)(•)CHCOO(-)), similar in structure to the stable alanine radical.</description><subject>Crystallization</subject><subject>Electron Spin Resonance Spectroscopy - methods</subject><subject>Free Radicals - chemistry</subject><subject>Free Radicals - radiation effects</subject><subject>Humans</subject><subject>Radiometry - methods</subject><subject>Temperature</subject><subject>Threonine - chemistry</subject><subject>Threonine - radiation effects</subject><subject>X-Rays</subject><issn>0144-8420</issn><issn>1742-3406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLAzEURoMotlY3_gDJUoTYPDvJUoovKIii4G7IZO7UkZmkJplF_71TWl19cDn3LA5Cl4zeMmrEPG7quXcD4-IITVkhORGSLo7RlDIpiZacTtBZSt-U8sIoeYomXBZSS62naHgLoccZ-g1Em4cI-JVU1tcYOnA5Bo97u_aQW4cjpOCtd4BTHuotDg2Otm6d7RJuPf4k0W5JG3c3m6HGHclfEYJv_fjR-nUH2MVtyiN_jk6aceDisDP08XD_vnwiq5fH5-Xdijiui0wWUlPBFhwaVahKG82oFo1klSpMwxpXKWpUZQtnhICqcWAoMF0rYyrmrGBihq733k0MPwOkXPZtctB11kMYUsmUpKOTKz6iN3vUxZBShKbcxLa3cVsyWu4yl2Pmcp95hK8O3qHqof5H_7qKX3dSex0</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Vanhaelewyn, Gauthier</creator><creator>Vrielinck, Henk</creator><creator>Callens, Freddy</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140601</creationdate><title>Room temperature Q-band electron magnetic resonance study of radicals in X-ray-irradiated l-threonine single crystals</title><author>Vanhaelewyn, Gauthier ; Vrielinck, Henk ; Callens, Freddy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c287t-64803162ef575b8981083f41b579f1fcb5095ba7c933ebfce90e18d599b1ca313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Crystallization</topic><topic>Electron Spin Resonance Spectroscopy - methods</topic><topic>Free Radicals - chemistry</topic><topic>Free Radicals - radiation effects</topic><topic>Humans</topic><topic>Radiometry - methods</topic><topic>Temperature</topic><topic>Threonine - chemistry</topic><topic>Threonine - radiation effects</topic><topic>X-Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vanhaelewyn, Gauthier</creatorcontrib><creatorcontrib>Vrielinck, Henk</creatorcontrib><creatorcontrib>Callens, Freddy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Radiation protection dosimetry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vanhaelewyn, Gauthier</au><au>Vrielinck, Henk</au><au>Callens, Freddy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Room temperature Q-band electron magnetic resonance study of radicals in X-ray-irradiated l-threonine single crystals</atitle><jtitle>Radiation protection dosimetry</jtitle><addtitle>Radiat Prot Dosimetry</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>159</volume><issue>1-4</issue><spage>155</spage><epage>163</epage><pages>155-163</pages><issn>0144-8420</issn><eissn>1742-3406</eissn><abstract>In the past, decennia radiation-induced radicals were successfully identified by electron magnetic resonance (EMR) in several solid-state amino acids and sugars. The authors present a room temperature (RT) EMR study of the stable radicals produced by X-ray-irradiation in the amino acid l-threonine (CH₃CH(OH)CH(NH₃ (+))COO(-)). Its chemical structure is similar to that of the well-known dosimetric material l-alanine (CH₃CH(NH₃(+))COO(-)), and radiation defects in l-threonine may straightforwardly be compared with the extensively studied l-alanine radicals. The hyperfine coupling tensors of three different radicals were determined at RT using electron nuclear double resonance. These results indicate that the two most abundant radicals share the same basic structure CH₃(•)C(OH)CH(NH₃(+))COO(-), obtained by H-abstraction, but are stabilised in slightly different conformations. The third radical is most probably obtained by deamination (CH₃CH(OH)(•)CHCOO(-)), similar in structure to the stable alanine radical.</abstract><cop>England</cop><pmid>24748488</pmid><doi>10.1093/rpd/ncu123</doi><tpages>9</tpages></addata></record> |
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| ispartof | Radiation protection dosimetry, 2014-06, Vol.159 (1-4), p.155-163 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Crystallization Electron Spin Resonance Spectroscopy - methods Free Radicals - chemistry Free Radicals - radiation effects Humans Radiometry - methods Temperature Threonine - chemistry Threonine - radiation effects X-Rays |
| title | Room temperature Q-band electron magnetic resonance study of radicals in X-ray-irradiated l-threonine single crystals |
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